How To Use Tumor suppressor gene In A Sentence
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These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention.
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Ptch is the gene responsible for NBCCS.9,10 However, to our knowledge no studies have examined OKCs for DNA damage in other known tumor suppressor genes or tumor oncogenes.
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Progen and its collaborators have focused their research on an enzyme known as lysine specific demethylase 1 (LSD1), which contributes to the silencing of important tumor suppressor genes.
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Objective To study the relationship between tumor suppressor gene PTEN , P 16, P 15 and primary cervical carcinomas.
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During these events, cells will carry multiple genetic alterations including inactivation of tumor suppressor genes and activation of oncogenes that will help the escape of the cells from normal growth control.
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A broad panel of 14 tumor suppressor genes, both associated and unassociated with neoplasia, were selected for microdissection-based genotyping.
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This difference indicates a striking increase in selection against nonsynonymous substitutions in oncogenes and tumor suppressor genes.
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Thus, most hereditary cancer syndromes are the result of inherited mutations in tumor suppressor genes rather than oncogenes.
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The FeLV-induced tumors are thought to be caused, at least in part, by somatically acquired insertional mutagenesis in which the integrated provirus may activate a proto-oncogene or disrupt a tumor suppressor gene.
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Interaction between metabolites of chemical carcinogens, such as polycyclic aromatic hydrocarbons, and DNA can cause mutation in oncogenes and tumor suppressor genes which is believed to initiate the carcinogenic process.
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However, its potential function as a tumor suppressor gene suggests a possible role in the malignant transformation of mesothelial cells.
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Evolutionary dynamics of tumor suppressor gene inactivation.
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These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention.
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Several genetic alterations to tumor suppressor genes have been shown to play a major role in tumorigenesis.
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If those mutations happen to be in oncogenes or tumor suppressor genes and they accumulate over time, it might cause a skin cancer to develop.
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Objective To study the relationship between tumor suppressor gene PTEN , P 16, P 15 and primary cervical carcinomas.
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Tumor suppressor genes are located on autosomal chromosomes.
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The genes found to undergo genetic alterations in cancer have been placed into two categories: oncogenes and tumor suppressor genes.
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Tumor suppressor genes play a key role in the regulation of cell growth.
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However, they point out that several genes, including potential oncogenes and tumor suppressor genes, failed to revert to never-smoker levels even after 30 years of cessation.
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P 53 gene is found in human tumors so far the most relevant tumor suppressor gene.
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In contrast, the chapter on cancer cytogenetics essentially assumes that the reader possesses an understanding of the concepts of oncogenes and tumor suppressor genes and their applications in cytogenetics.
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Neurofibromatosis type 1 is a common autosomal dominant disorder with a high rate of penetrance. It is caused by the mutation of the tumor suppressor gene NF1, which encodes neurofibromin.
