How To Use Telomere In A Sentence
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In normal somatic cells, the telomeres shorten with replicative age, and telomerase is not detected.
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All transfectants lacked detectable telomerase activity, showed progressive telomere shortening and ultimately arrested and died.
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And, we realized the old truism from the original cytogenetics which was that the telomere is really important for protecting ends and, as you might expect, the cell actually devotes all sorts of machinery to make sure that never goes wrong, or goes wrong as little as possible.
Elizabeth H. Blackburn - Interview
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Telomeres are near the nuclear envelope; the two 5S rDNA loci remain unpaired.
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Which chromosomes have the shortest telomeres depends only on telomere length in the original parent mice.
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The region neighboring the telomeres also appears to be rich in duplicated regions.
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In nature, a chromosome can be lengthened by the enzyme telomerase, which adds new TTAGGG sequences to the end of the telomere.
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Telomere locates on the terminal of DNA containing repeat DNA sequence.
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Can telomere maintenance be eliminated effectively ( and selectively ) enough by more tractable approaches?
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Researchers estimate that telomere maintenance activity occurs in about 90 % of human cancers.
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telomeres act as caps to keep the sticky ends of chromosomes from randomly clumping together
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In a pioneering experiment, they demonstrated that telomere DNA from one organism, a unicellular ciliated protozoan called Tetrahymena thermophila, would protect and stabilise chromosomes in an entirely different organism, yeast.
The 2009 Nobel Prize in Physiology or Medicine - Presentation Speech
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To commenter "antiproton": I am well researched on telomeres, telomerase and their role in both cancer and stem cells.
HH Com 608 (607 is reading Against the Day--still)
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When no telomere is present, attempts to replicate this uncapped end may be responsible for the apparent "fusions" of the replicated chromatids at the position of the previous break as well as for perpetuating the chromatid type of breakage-fusion-bridge cycle in successive mitoses.
Nobel Lecture The Significance of Responses of the Genome to Challenge
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A crossover at the meiotic prophase, as shown in Fig. 2, produces a dicentric chromosome that simulates two normal chromosomes attached together at the ends of their short arms, and a fragement chromosome with telomeres at both ends.
Nobel Lecture The Significance of Responses of the Genome to Challenge
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In eukaryotic cells with telomeres composed of short tandem repeats, this involves the enzyme telomerase.
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All of the strains were passaged for >30 generations before genomic DNA was isolated; additional passages of 60 generations showed no differences in telomere lengths from those illustrated in Fig 4B (data not shown).
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The use of circular DNA in mitochondria has been taken as evidence, but there are also many organisms that have linear mitochondrial chromosomes with eukaryotic telomeres.
A critique on the endosymbiotic theory for the origin of mitochondria
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Telomerase is RNA dependent DNA polymerase, acts to synthesize DNA repeat fragment of telomeres , which is associated with immortalization of cells.
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The region neighboring the telomeres also appears to be rich in duplicated regions.
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Each segment of a telomere is like a ticket that gives it permission to divide.
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Without telomeres, the chromosomes would ‘fray’ when the cells divided.
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Further, in most organisms there is a virtual absence of exchange in heterochromatin and a reduction of exchange frequencies in euchromatin that lies near chromosomal elements such as centromeres and telomeres.
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Your discoveries have revealed how the conserved function of telomere repeat sequences can maintain chromosomal and genetic stability and how synthesis of telomere DNA is achieved by the enzyme telomerase.
The 2009 Nobel Prize in Physiology or Medicine - Presentation Speech
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If any components of the telomerase are missing, telomeres are gradually shortened and most cells die.
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Next, she and Jack Szostak performed an experiment showing that telomeres from one species, a pond-dwelling single-celled organism called tetrahymena, could protect DNA molecules, or mini-chromosomes, from a very distant organism, yeast.
The 2009 Nobel Prize in Physiology or Medicine - Speed Read
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It has long been thought that the grouping of telomeres is important for chromosome pairing and subsequent synapsis.
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Telomerase system is the genetic name of telomerase and telomere.
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So, when a telomere gets short, that's when either senescence or apoptosis is triggered.
Carol W. Greider - Interview
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And, we realized the old truism from the original cytogenetics which was that the telomere is really important for protecting ends and, as you might expect, the cell actually devotes all sorts of machinery to make sure that never goes wrong, or goes wrong as little as possible.
Elizabeth H. Blackburn - Interview
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Telomere shortening is thus one of several factors that affect the ageing process.
The 2009 Nobel Prize in Physiology or Medicine - Presentation Speech
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Telomeres, the natural ends of linear chromosomes, are maintained by the specialized reverse transcriptase called telomerase.
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Do cancers always regress before killing us if they cannot maintain their telomeres?
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Telomere function is one of the factors that determine radiosensitivity of cells and whole organism.
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Several studies show involvement of telomeres in the pairing of homologs during meiosis.
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The implications that the whole machinery was conserved across kingdoms; that was obvious as soon as we saw that the tetrahymena telomeres worked in yeast.
Jack W. Szostak - Interview
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It has long been thought that the grouping of telomeres is important for chromosome pairing and subsequent synapsis.
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The telomeres being studied in Lee's project act as a kind of protective cap for chromosomal ends - much like the plastic aglet at the end of a shoelace, for example - allowing cells to retain their biological information.
Newswise: Latest News
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Every time a chromosome replicates itself, its telomeres shorten in length.
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To test whether either mutant underwent delayed telomere elongation, the mutant strains were extensively passaged by serial colony streaking and telomere lengths were monitored periodically.
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A crossover at the meiotic prophase, as shown in Fig. 2, produces a dicentric chromosome that simulates two normal chromosomes attached together at the ends of their short arms, and a fragement chromosome with telomeres at both ends.
Nobel Lecture The Significance of Responses of the Genome to Challenge
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Several studies show involvement of telomeres in the pairing of homologs during meiosis.
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It turned out to be unique in its structure and to consist of an enzymatically active protein component plus an RNA component that serves as a template for the formation of new telomere DNA.
The 2009 Nobel Prize in Physiology or Medicine - Presentation Speech
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A feature shared by senescent cells in culture and in vivo is shortening of the telomeres.
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A feature shared by senescent cells in culture and in vivo is shortening of the telomeres.
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Several nucleoside-based inhibitors of these viral enzymes, including that of the HIV virus, also typically show modest inhibition of telomere synthesis.
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Strains with mutations in both genes are very sensitive to DNA damaging agents, have very short telomeres, and undergo cellular senescence.
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It is known that induction of telomere shortening leads to the extinction of yeast clones similar to a senescent phenotype.
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Although the relationship between cellular and organismic age is not well understood, chronological age is inversely correlated with telomere length in adults across all age groups.
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These two genes are tightly linked to the left telomere of the X chromosome.
