How To Use Scrapie In A Sentence
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In the virino model, the host protein protects the scrapie agent nucleic acid from degradation and prevents the host raising an immune response, since the protein/nucleic acid complex is seen as ‘self’.
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Pathologists have identified degenerative changes in brain samples of diseased cattle similar to scrapie-infected sheep brain.
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Scrapie is still common in sheep, but doesn't seem to strike people.
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Extensive search through the model parameter space produced only long-term scrapie persistence for ε3 ≥ 0.01.
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Sheep are susceptible to their own brain wasting disease called scrapie, but this disease has never been shown to be transmissible to humans.
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Healthy sheep inoculated with tissue from animals with scrapie took years to develop symptoms, far longer than for any other known infection.
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Many rams have already been genotyped for their ability to pass on resistance to scrapie.
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Although well-established in scrapie and, more recently, in BSE, comparatively little is known about the possibility of prion strains in chronic wasting disease (CWD), a disease affecting free ranging and captive cervids, primarily in North America.
CWD Worse Than Ever In Wisconsin Counties
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For many years after their discovery as the agents of some rare neurodegenerative diseases in mammals, such as scrapie in sheep and human Creutzfeldt-Jakob disease and kuru, prions have remained a truly esoteric research topic.
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I didn't drive it particularly well, so I was a little 'scrapie' on the front nine," he said.
Columnist: Keith Groller
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Since the early 1990s, scientists have become increasingly concerned that sheep diagnosed with scrapie may actually have BSE.
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For many years after their discovery as the agents of some rare neurodegenerative diseases in mammals, such as scrapie in sheep and human Creutzfeldt-Jakob disease and kuru, prions have remained a truly esoteric research topic.
Of Prions and People - The Panda's Thumb
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Most Western nations tolerate Salmonella in chickens and scrapie in sheep, but this must change.
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BSE is almost impossible to distinguish from scrapie, a disease attacking the brain of sheep.
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Yet these proteins self-replicate and cause horrible brain-wasting maladies such as mad-cow disease, Scrapie, and Creutzfeld-Jacob disease.
Jeff Schweitzer: Redefining Life: God Need Not Apply
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I learned neuropathology from the head of the department, R.M. Barlow, and from Hugh Fraser who was doing seminal studies with Alan Dickinson defining the genetics of the scrapie mouse model.
Peter C. Doherty - Autobiography
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(85 percent) of prion diseases in humans can be attributed to a spontaneous structural conversion of the cellular prion protein: Originally dominated by alpha-helices as structural elements, the prion protein is transformed into its misfolded "scrapie" isoform which is dominated by accordion-like folded protein sheets, so called beta-sheets.
Innovations-report
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The scrapie agent in sheep may be similar to viroids.
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According to Richard Rhodes '"Deadly Feasts", all about the mutation of the disease called "scrapie" in sheep that became BSE in cows, then Creutzfeld-Jakob in humans, those unused brains and bones have been ground up and used in fertilizer as well as, at one time, cattle feed.
Your Right Hand Thief
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Sheep scrapie, a similar prion disease, passes from ewes to their lambs.
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The program also encourages producers to select for resistance and to use scrapie-resistant rams in flocks that have risk factors for scrapie.
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There are fears that BSE in sheep could mimic scrapie, which passes easily by horizontal infection from sheep to sheep.
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Since 1997, almost 300 Quebec farmers have been ordered to destroy more than 12,000 sheep feared to be carrying the disease called scrapie.
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In the mid-1700s, when it was first recognized in sheep, the disease was called scrapie, because suffering animals tended to rub their skins raw.
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Lambs can develop scrapie, but that disease isn't known how to harm people.
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BSE originated in the early 1980s when cattle were fed by-products from sheep suffering from a brain disease called scrapie, whose cause appears to be a chemically stable protein aggregate called a prion.
On Food and Cooking, The Science and Lore of the Kitchen
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The steady state prevalence is however the same for different values of β1 corresponding to long-term scrapie persistence (
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Scrapie is a chronic disease of sheep which is transmitted by a filterable particle that is resistant to heat and formalin fixation.
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However, to test the broader implications of our results, simulations carried out with different dominance assumptions (i.e. SL/RH genotypes are also susceptible to scrapie and have different lamb mortality rates than SL/SL genotypes) resulted in similar long-term scrapie persistence patterns, albeit for different ranges of model parameters.
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Biologically, the symptoms of the relatively common disease of scrapie in sheep are very similar to those of BSE.
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The holes were unmistakably like scrapie, the sheep sickness that was the first documented spongiform encephalopathy.
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Other prion diseases, in animals, there is a disease of cattle called BSE or bovine spongiform encephalopathy (commonly called mad cow disease), in sheep there is "scrapie" and in humans, there is GerstmannSträusslerScheinker syndrome (GSS), fatal familial insomnia (FFI) and kuru-kuru in humans in Papua New Guinea.
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I have never accepted that BSE came as a result of cattle eating meat and bonemeal containing sheep infected with scrapie.
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The only difference is that meat infected with scrapie is harmless to humans, whilst BSE kills.
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Their flock now boasts 35 ewes and 2 rams and, as of March, the sheep have been deemed scrapie free by inspectors.
