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[ UK /ɹɪfɹˈæktəɹˌi/ ]
[ US /ɹəˈfɹæktɝi/ ]
ADJECTIVE
  1. temporarily unresponsive or not fully responsive to a process or stimulus
    the refractory period of a muscle fiber
  2. stubbornly resistant to authority or control
    a fractious animal that would not submit to the harness
    a refractory child
  3. not responding to treatment
    a refractory case of acne
    a stubborn infection
    stubborn rust stains
NOUN
  1. lining consisting of material with a high melting point; used to line the inside walls of a furnace

How To Use refractory In A Sentence

  • Very high dosage fluphenazine for nonchronic treatment-refractory patients. The Neuropsychiatric Guide to Modern Everyday Psychiatry
  • That enviably resilient Bayesian model has been cracked, in the eyes of many philosophers, by such refractory phenomena as akrasia or ‘weakness of will.’
  • In WS, the three PAI loci are highly refractory to cleavage by either HpaII or MspI, diagnostic of dense CG and CCG methylation of the recognition site.
  • They are generally so refractory, self-conceited, obstinate, so firmly addicted to that religion in which they have been bred and brought up, that no persuasion, no terror, no persecution, can divert them. Anatomy of Melancholy
  • In refractory cases, monounsaturated fats may replace carbohydrates, but weight and lipid profile should be closely monitored.
  • This, in turn, renders cells refractory to subsequent infection by the same or other viruses that use the CD4 receptor for entry; thus creating a state of super-infection immunity.
  • Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients Naturejobs - All Jobs
  • * The effect of this little bit of science may be thus stated -- Men for two years had been punished as refractory for not making all day two thousand revolutions per hour of a 15 lb. crank, when all the while it was a _45 lb. crank_ they had been vainly struggling against all day. It Is Never Too Late to Mend
  • ROME -- Long-term gout patients should not be considered "refractory" -- and clinicians should not treat them as such -- until uric crystals are dissolved to the point that flares of pain are prevented, a researcher said here. Medicaid and Medicare
  • Fumed silica is used as a filler in the cement and refractory materials industries, as well as in heat insulation and filling material for synthetic rubbers, polymers and grouts. Silicon
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