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proto-oncogene

NOUN
  1. a normal gene that has the potential to become an oncogene

How To Use proto-oncogene In A Sentence

  • Activating even two potent proto-oncogenes had not recapitulated the full syndrome of cancer in every cell of the mouse. The Emperor of All Maladies
  • It was shown previously that somatic hypermutability of proto-oncogenes can induce development of lymphomas. PLoS ONE Alerts: New Articles
  • The FeLV-induced tumors are thought to be caused, at least in part, by somatically acquired insertional mutagenesis in which the integrated provirus may activate a proto-oncogene or disrupt a tumor suppressor gene.
  • The normal expression of proto-oncogenes plays an important role in the regulation of spermatogonial mitosis , spermatocyte meiosis as well as spermiogenesis and sperm maturation.
  • To test the roles of other oncogenes and environmental stimuli, Leder created a second OncoMouse, in which two activated proto-oncogenes, ras and myc, were engineered into the chromosome and expressed in breast cells. The Emperor of All Maladies
  • Cyclin D1 is a key cell cycle regulator and a candidate proto-oncogene, whose deregulation has been implicated in pathogenesis of several types of cancers, including NPC.
  • Objective To explore the correlation between chromosome fragile site in peripheral blood lymphocytes and proto-oncogene expression rate in patients with hepatocellular carcinoma.
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