NOUN
- enzyme produced by certain bacteria that inactivates penicillin and results in resistance to that antibiotic
How To Use penicillinase In A Sentence
- C. Resistance to penicillin is mediated both by plasmid-encoded penicillinase and by changes in chromosome-encoded proteins that control the permeability of the drug. Recently Uploaded Slideshows
- After all, the resistant strain has the genetic information necessary to produce penicillinase, which is a complex chemical.
- The object of interest was the so-called large domain of the TEM-1 penicillinase, an enzyme that breaks down antibiotics related to penicillin. Axe (2004) and the evolution of enzyme function - The Panda's Thumb
- These chemically modified penicillins have a side chain that inhibits the action of penicillinase.
- Recall that Axe did not work with the native TEM-1 penicillinase, but rather with a variant that had a lower activity. Axe (2004) and the evolution of enzyme function - The Panda's Thumb
- Staphylococcus aureus (MRSA), resulting in the concept that MRSA has emerged on a few occasions after penicillinase-stable β-lactam antibiotics were introduced to clinical practice, followed by intercontinental spread of individual clones. Proceedings of the National Academy of Sciences current issue
- Consider a penicillinase-resistant penicillin (such as methicillin or nafcillin) or vancomycin plus an aminoglycoside or aztreonam.
- Oral antibiotics are usually used in the treatment and include first-generation cephalosporins, penicillinase-resistant penicillins, macrolides, and fluoroquinolones.
- Penicillin was first used in the early 1940s and by 1950, most Staphylococcus aureus organisms were resistant to the drug by virtue of elaboration of a penicillinase enzyme.
- A control gene regulates the production of an enzyme that destroys the antibiotic, e.g. penicillinase which destroys penicillin.
