How To Use Osteoclast In A Sentence
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Activates and increases the formation of osteoclasts (multinucleate cells that break down calcified bone matrix), increasing bone destruction and making calcium and phosphorous available to the rest of the body.
Anatomy 101: The Parathyroid Gland And How It Affects Our Health.
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Col1a1-Krm2 mice display a cell-autonomous differentiation defect, impaired canonical Wnt signalling and decreased production of the osteoclast inhibitory factor Opg. To determine whether the observed effects of Krm2 on bone remodeling are physiologically relevant, we analyzed the skeletal phenotype of 24 weeks old
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The rate at which cells called osteoclasts break down bone is slowed, and the production of new bone increases.
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Moreover, the number of osteoclasts increased as the cumulative dose of of these osteoclasts were giant cells with pyknotic nuclei that were adjacent to superficial resorption cavities.
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Trolox also suppressed interleukin-1-induced osteoclast formation and bone loss in mouse calvarial bone.
Journal of Biological Chemistry current issue
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It is well established that osteoclasts, specialized multinucleated giant cells responsible for bone resorption, i.e. osteoclasts, were derived from activated macrophages and play a role in the direct lysis of bone.
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The transient activation of bone resorption function, presented as the temporary increase of osteoclasts number and mostly maintenance of its function of excreting acid and protease.
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Tnfrsf11b, the gene encoding the osteoclast-inhibitory factor Opg, is known to be induced by canonical Wnt signaling in osteoblasts
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Note the presence of numerous osteoclasts lining the bone trabeculae.
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Meghji S, Morrison MS, Henderson B, Arnett TR. pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis.
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One of the menaquinone forms of vitamin K (MK-4, also called menatetrenone) has repeatedly been show to block formation of too many osteoclasts and perhaps also to initiate their programmed cell death (a process called apoptosis).
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When interference is called for, if the callus is not yet firmly consolidated, it may be possible, under an anæsthetic, to bend the bone into position or to re-break it, either with the hands or by means of a strong mechanical contrivance known as an osteoclast.
Manual of Surgery Volume Second: Extremities—Head—Neck. Sixth Edition.
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This first-in-class monoclonal antibody targets RANK ligand, which is involved in bone-degenerating osteoclasts.
PharmaTimes World News
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And what scientists have found is that in people who have osteopetrosis, the osteoclasts that normally breakdown bone cannot work properly.
- The Naked Scientists Naked Science Radio Show PODCAST - Stripping Down Science
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Around the age of 30, a second phase called re-modelling begins in which old bone is dissolved by the osteoclast cells and new bone becomes deposited (remineralised) by the other, related, class of cells called osteoblasts.
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Slide 26: (OPG), also known as osteoclast inhibitory factor (OCIF) is a soluble decoy receptor for RANKL (111).
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Frequent osteoclast - like giant cells are present.
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(BMPs), Wnts, and Ihh, all of which are important for osteogenesis, as well as RANKL and VEGF, which promote osteoclast activation and vascular invasion Hypertrophic differentiation is not only an essential step in endochondral ossification, but it also seems to be a pathological event in early osteoarthritis.
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Note the presence of numerous osteoclasts lining the bone trabeculae.
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Elevated levels of the hormone calcitonin can prevent osteoclastic bone resorption.
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(C) Histomorphometric quantification of the trabecular bone volume and osteoclast surface per bone surface (OcS/BS).
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Oxygen free radicals stimulate osteoclasts, the cells that resorb or break down bone.
Forever Young
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Osteoblasts help form new bone, while osteoclasts resorb old bone.
You Staying Young
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Localization of polynuclear osteoclasts in limb bones of ribbed newt were analyzed in consideration of calcium content in different bone structures.
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They activate mature osteoclasts indirectly through osteoblasts, inhibit osteoclast cell death, and stimulate osteoclast progenitor formation.
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One of the menaquinone forms of vitamin K (MK-4, also called menatetrenone) has repeatedly been show to block formation of too many osteoclasts and perhaps also to initiate their programmed cell death (a process called apoptosis).
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RANKL, also known as osteoclast differentiation factor (ODF), tumor necrosis factor - related activation-induced cytokine (TRANCE) and osteoprotegerin ligand, is a member of the TNF ligand family (106) produced in osteoblastic lineage cells and activated T cells
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Undifferentiated carcinomas with osteoclastic - like giant cells carry a similar prognosis to ductal adenocarcinoma.
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Incidentally, osteoclast is a type of cell that attacks the bone.
CNN Transcript May 3, 2007
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Intranasal calcitonin is a polypeptide hormone that also inhibits osteoclastic activity.
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Giant cells (myeloplaxes, osteoclasts), large, multinucleated, protoplasmic masses, are also to be found in both sorts of adult marrow, but more particularly in red marrow.
II. Osteology. 2. Bone
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The progenitors of osteoclasts are from the hematopoietic cell line and the osteoblasts originate from the marrow stroma.
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Williams also showed that genistein decreased acid secretion by osteoclasts, thus decreasing bone dissolution.
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Teitelbaum S, Ross FP (2003) Genetic regulation of osteoclast development and function.
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An osteoblast engaged in the absorption instead of the formation of bone is called an osteoclast.
Text Book of Biology, Part 1: Vertebrata
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Skeleton Crew osteoclast The drugs target a protein called RANK Ligand, which helps regulate cells called osteoclasts that break down bone.
Week in Words
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Immunohistochemistry, the osteoclast - like giant cells were positive for CD 68. Vim, α1 - ACT and negative for CK, EMA.
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Is radioresistant 149) The treatment of osteoclastoma includes the following measures except:
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Vitamin D indirectly stimulates osteoclasts to resorb bone and is necessary for the intestinal absorption of calcium.
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Building new bone is in part a problem of balance: regulating osteocytes, that add bone, and osteoclasts, that break it down.