1. cell that functions in the breakdown and resorption of bone tissue
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How To Use osteoclast In A Sentence

  • Activates and increases the formation of osteoclasts (multinucleate cells that break down calcified bone matrix), increasing bone destruction and making calcium and phosphorous available to the rest of the body. Anatomy 101: The Parathyroid Gland And How It Affects Our Health.
  • Col1a1-Krm2 mice display a cell-autonomous differentiation defect, impaired canonical Wnt signalling and decreased production of the osteoclast inhibitory factor Opg. To determine whether the observed effects of Krm2 on bone remodeling are physiologically relevant, we analyzed the skeletal phenotype of 24 weeks old PLoS ONE Alerts: New Articles
  • The rate at which cells called osteoclasts break down bone is slowed, and the production of new bone increases.
  • Moreover, the number of osteoclasts increased as the cumulative dose of of these osteoclasts were giant cells with pyknotic nuclei that were adjacent to superficial resorption cavities. Medlogs - Recent stories
  • Trolox also suppressed interleukin-1-induced osteoclast formation and bone loss in mouse calvarial bone. Journal of Biological Chemistry current issue
  • It is well established that osteoclasts, specialized multinucleated giant cells responsible for bone resorption, i.e. osteoclasts, were derived from activated macrophages and play a role in the direct lysis of bone.
  • The transient activation of bone resorption function, presented as the temporary increase of osteoclasts number and mostly maintenance of its function of excreting acid and protease.
  • Tnfrsf11b, the gene encoding the osteoclast-inhibitory factor Opg, is known to be induced by canonical Wnt signaling in osteoblasts PLoS ONE Alerts: New Articles
  • Note the presence of numerous osteoclasts lining the bone trabeculae.
  • Meghji S, Morrison MS, Henderson B, Arnett TR. pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis. The World's Healthiest Foods
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