How To Use Oncogene In A Sentence
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Cyclin D1 is a key cell cycle regulator and a candidate proto-oncogene, whose deregulation has been implicated in pathogenesis of several types of cancers, including NPC.
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The immortalized cells were then further characterized by heterotransplantation in Nude mice; immunohistochemical staining for relevant HNSCC biomarkers; flow cytometry for surface markers; cytogenetic karyotypic analysis; human papillomavirus and Epstein-Barr virus screening; qRT-PCR for oncogene and cytokine analysis; investigation of activated, cleaved Notch1 levels; and detailed 35,000 gene microarray analysis.
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Interaction between metabolites of chemical carcinogens, such as polycyclic aromatic hydrocarbons, and DNA can cause mutation in oncogenes and tumor suppressor genes which is believed to initiate the carcinogenic process.
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In addition, the work is the first to show that a class of proteins called steroid receptors, of which the androgen receptor is a member, can become cancer-causing genes known as oncogenes.
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Altieri will also be the West Philadelphia institute's chief scientific officer and professor in the Wistar molecular and cellular oncogenesis program.
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In any case, what he found was that treating two different leukemia and lymphoma cell lines with ascorbate at those concentrations before treating them with chemotherapeutic agents, including mechanistically dissimilar agents such as doxorubicin, which intercalates with DNA and causes DNA breaks; methotrexate, which inhibits folate metabolism; cisplatin, which crosslinks DNA; vincristine, which interferes with microtubule function; and imatinib mesylate (better known by its trade name of Gleevec), a selective inhibitor of the activity of a protein called bcr-abl, which is the oncogene that plays a central role in the development of chronic myelogenous leukemia (CML).
Adrian Monck
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The FeLV-induced tumors are thought to be caused, at least in part, by somatically acquired insertional mutagenesis in which the integrated provirus may activate a proto-oncogene or disrupt a tumor suppressor gene.
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The normal expression of proto-oncogenes plays an important role in the regulation of spermatogonial mitosis , spermatocyte meiosis as well as spermiogenesis and sperm maturation.
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Thus, most hereditary cancer syndromes are the result of inherited mutations in tumor suppressor genes rather than oncogenes.
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These ranged from large genomic amplifications or deletions, such as amplification of the entire 17q arm, to more discrete changes, such as a two-megabase amplification encompassing the MYC oncogene.
Embryonic Stem Cell Lines Prove Unstable | Impact Lab
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This mechanism has been shown to be operational in the case of various oncogenes and tumour suppressor genes.
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For example, a set of cancer-promoting oncogenes called RAS was down-regulated in these men.
Changing Your Lifestyle Can Change Your Genes
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Invitro, oncogenes cooperate to transform cells and render them tumorigenic.
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This difference indicates a striking increase in selection against nonsynonymous substitutions in oncogenes and tumor suppressor genes.
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To test the roles of other oncogenes and environmental stimuli, Leder created a second OncoMouse, in which two activated proto-oncogenes, ras and myc, were engineered into the chromosome and expressed in breast cells.
The Emperor of All Maladies
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High-level quality research projects supported by the INCa through the Cancéropôles networks should allow to better understand the molecular mechanisms involved in oncogenesis which is crucial to define new therapeutic targets and to develop innovative treatments for the benefit of all patients.
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Invitro certain combinations of oncogenes cooperate to transform primary rat cells.
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Invitro, oncogenes cooperate to transform cells and render them tumorigenic.
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Plainly in any less desperate case the risk of activating oncogenes would absolutely forbid the use of such a drug.
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These are mutations frequently detected in oncogenes or tumour suppressor genes from human tumours.
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Her work has continued today to understand how breakpoints influence the expression of microRNAs involved in oncogenesis.
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During these events, cells will carry multiple genetic alterations including inactivation of tumor suppressor genes and activation of oncogenes that will help the escape of the cells from normal growth control.
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Objective To explore the correlation between chromosome fragile site in peripheral blood lymphocytes and proto-oncogene expression rate in patients with hepatocellular carcinoma.
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Much effort in cancer research has gone into identifying and investigating the key genes known as oncogenes; when mutated to high activity, oncogenes stimulate the cell to form cancers.
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Ptch is the gene responsible for NBCCS.9,10 However, to our knowledge no studies have examined OKCs for DNA damage in other known tumor suppressor genes or tumor oncogenes.
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The other class, that of anti-oncogenes or tumor suppressors, is recessive in oncogenesis; cancer results when both normal copies have been mutated or deleted.
The Emperor of All Maladies
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Cellular oncogenes are generally genes that promote normal replication, and as such they are under tight regulatory control to prevent abberant growth.
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The culprit gene, called WWP2, is an enzymic bonding agent found inside cancer cells, the researchers explained in their study, published in the journal Oncogene Monday.
Blocking 'Rogue Gene' Could Stop Cancer Spread
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Recent studies have been investigating these conditions for the presence of specific translocations and the expression of oncogenes and tumour suppressor genes.
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There are two more groups of oncogene products with phosphokinase activity; firstly tyrosine/phosphokinase which lack receptor function and is located at the inside of the cytoplasmic membrane, and secondly serine/threonine phosphokinase which is found in the cytoplasm.
Nobel Prize in Physiology or Medicine 1989 - Press Release
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Many cancers result from the acquisition of mutations in a family of genes called oncogenes, which normally serve important housekeeping functions for our cells.
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The researchers first discovered the fusion protein acts like an oncogene, or cancer-causing gene, that can promote unrestricted cell growth.
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With all the important advances in genomic sequencing, one can sometimes forget that molecular oncologists have been busy for decades to uncover what happens at the molecular level in oncogenesis.
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POK proteins are critical in embryonic development, cellular differentiation and oncogenesis, according to the National Cancer Institute.
Boing Boing: December 18, 2005 - December 24, 2005 Archives
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In contrast, the chapter on cancer cytogenetics essentially assumes that the reader possesses an understanding of the concepts of oncogenes and tumor suppressor genes and their applications in cytogenetics.
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As CDK4 is known to phosphorylate Rb, and is a known oncogene, the independent oncogenic role of
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Many cancers result from the acquisition of mutations in a family of genes called oncogenes, which normally serve important housekeeping functions for our cells.
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Oncogenes control normal growth cells and their division.
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Richard Shope, Evolutionary episodes in the concept of viral oncogenesis, Perspectives Biol.
Peyton Rous - Nobel Lecture
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Activating even two potent proto-oncogenes had not recapitulated the full syndrome of cancer in every cell of the mouse.
The Emperor of All Maladies
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Human herpesvirus 8 contains three potential oncogenes that can transform cell lines in vitro.
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Invitro, oncogenes cooperate to transform cells and render them tumorigenic.
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However, they point out that several genes, including potential oncogenes and tumor suppressor genes, failed to revert to never-smoker levels even after 30 years of cessation.
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Invitro certain combinations of oncogenes cooperate to transform primary rat cells.
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Many leukemic oncogenes form as a consequence of gene fusions or mutation that result in the activation or overexpression of a tyrosine kinase.
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The genes found to undergo genetic alterations in cancer have been placed into two categories: oncogenes and tumor suppressor genes.
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One study has involved a group of closely related developmental genes, the Ras oncogenes.
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Invitro certain combinations of oncogenes cooperate to transform primary rat cells.
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Plainly in any less desperate case the risk of activating oncogenes would absolutely forbid the use of such a drug.
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A normal gene that has the potential to become an oncogene.
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Incorporation of this foreign DNA may lead to mutations and oncogenesis by several possible mechanisms:
Your Right Hand Thief
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Thus the presence of p53 mutation may trigger precipitate the derailment of the cell cycle machinery, rendering cells susceptible to additional aberrations in other important oncogenes and tumour suppressor genes.
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More information: CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis.
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If those mutations happen to be in oncogenes or tumor suppressor genes and they accumulate over time, it might cause a skin cancer to develop.
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Objective:To investigate the changes in histogenesis and expressions of related oncogene protein in recurrent bone tumor.
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It was shown previously that somatic hypermutability of proto-oncogenes can induce development of lymphomas.
PLoS ONE Alerts: New Articles
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Objective: To investigate the relationship between the transcriptional expression of RASSF1A(Ras association domain family 1A gene) and oncogenesis and the development of endometrial carcinoma.