NOUN
- a simple protein containing mainly basic amino acids; present in cell nuclei in association with nucleic acids
How To Use histone In A Sentence
- Histones physically control access to genes, and adding small functional groups such as acetyl or methyl units to them can selectively switch certain genes on and off. Innovations-report
- A: Titration of histones into LDL (final concentration 1.25 mg/ml by protein) was carried out for 1 hr in PBS at 21°C, and protein aggregation measured by spectrophotometric absorbance at 680 nm. PLoS ONE Alerts: New Articles
- Sperm chromatin contains protamines that must be replaced by histones before undergoing condensation.
- The importance of the nucleosome in gene regulation is supported by the finding that mutations that alter intracellular levels of histones lead to transcriptional derepression of a variety of genes.
- Histone proteins are essential components of nucleosomes in eukaryotic chromosomes.
- The packaging of DNA with histones into nucleosomes and higher-order chromatin structures has profound effects on transcription initiation.
- Histones also demonstrate a strong affinity for binding anionic phospholipids such as phosphatidylserine and cardiolipin PLoS ONE Alerts: New Articles
- At that time Alex was studying the role of mono-ubiquitination of histones (for the histone-ubiquitin adduct H2A known also as protein A24 or uH2A, see above). Aaron Ciechanover - Autobiography
- Histones are small basic proteins encoded by a multigene family and are responsible for the nucleosomal organization of chromatin in eukaryotes.
- These DNA-binding proteins include polymerases, helicases, nucleases, isomerases, ligases, histones, and others.
