How To Use Choline In A Sentence
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Found in various forms throughout the body, choline, a member of the vitamin B complex family, is involved in the creation of cell membranes.
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Inside our bodies, the B vitamins folate and choline work in a delicate balance.
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Mustard, salt, picholine olives and super-thin rye toasts give the house-cured gravlax just the right accents.
SFGate: Top News Stories
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Noradrenaline decreased I_(K) distinctly. Isoprenaline and acetylcholine showed no effect on I_(K) in isolated rat hepatocytes.
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Anticholinesterase drugs stimulate nerve-impulse transmission, and corticosteroids may help.
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For lipid overlay, 0.05 mM biotinylated phosphatidylethanolamine was incorporated to the preparation of PPM or IPM with a 1 / 200 molar ratio toward L-α-lysophosphatidylcholine.
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• Healthy fats to keep their cell walls integral but permeable -- such as omega-3 fats, and phosphatidylserine and phosphatidyl choline, available from foods and supplements
Alison Rose Levy: Fix Your Mood with Brain Food
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The primary species of bound UCB in our models were: undissociated diacid for phosphatidylcholine, dianion for dodecyl maltoside micelles and cyclodextrins, and both monoanions and dianion for sodium taurocholate.
BioMed Central - Latest articles
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Both antihistamines and anticholinergics can have anticholinergic side effects, including dry mouth, urinary retention, blurred vision, and exacerbation of narrow-angle glaucoma.
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The basal ganglia of the brain are peculiarly rich in acetylcholine, the presence of which must presumably have some significance; and suggestive effects of eserine and of acetylcholine, injected into the ventricles of the brain, have been described.
Sir Henry Dale - Nobel Lecture
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All nerve agents act by inhibiting the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine.
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Robertson RT, Gallardo KA, Claytor KJ, Ha DH, Ku KH, et al. (1998) Neonatal treatment with 192 IgG-saporin produces long-term forebrain cholinergic deficits and reduces dendritic branching and spine density of neocortical pyramidal neurons.
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Our data cofirm previous evidences, that long-term neuronal consequences of high-dose cholinergic activation are not necessarily derived from prolonged seizure activation (as seen in SE)
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-- A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
PhysOrg.com - latest science and technology news stories
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This neurotoxic action kills bugs by reducing the level of a certain enzyme (acetylcholinesterase) that clears an important neurotransmitter chemical (acetylcholine) out of the junction between nerve cells.
Dr. Walter Crinnion: Could Organic Produce Be the New Ritalin?
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In spinach and sugar beet the enzymes responsible for converting choline into betaine have been characterized, and the corresponding genes cloned and sequenced.
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Anticholinergics have been used in an attempt to decrease gastric secretions and increase pH. As with the use of nasogastric tubes, anticholinergics do not decrease hospital stay or pain.
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He found that the psychotomimetic ingredient in all of them was some kind of anticholinergic alkaloid—very similar to atropine and scopolamine.
Over the Edge
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Dry mouth, which can be brought on by neuroleptics, antidepressants, and anticholinergics, may worsen the problem.
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Lyso platelet activating factor and alkyl acyl glycerophosphocholine were not significantly higher in Crohn's disease than in controls.
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Like cholinergic urticaria, variant exercise-induced anaphylaxis produces small, punctate, erythematous papules and is associated with increased plasma histamine levels.
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Thus, in 1914, anticholinergics by injection or inhalation were considered as first-line asthma therapies.
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Acetylcholine esterase inhibitor (neostigmine): indications: colonic pseudo-obstruction
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In the case of SPM, the presence of the highly hydratable and relatively bulky zwitterion, phosphorylcholine, further affects ceramide behavior.
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The administration of antihypertensive and anticholinergic medications also impairs salivary functions and promotes xerostomia.
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Blood - Determination of cholinesterase activity - Spectrophotometric method - Acetylthiocholine and dithio - bis - ( nitrobenzoic acid ) method.
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A man takes three sips of kalla, and he touches off the release of neurotransmitters, acetylcholine and tryptamine and serotonin.
THE BROKEN GOD
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Its anticholinergic ancestor, ipratropium or Atrovent was taken twice a day.
Spiriva and Stroke-FDA's warning may be too much (or too soon) information
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Eat an apple or two: Apples stimulate production of the neurotransmitter acetylcholine, which is what the Alzheimer's drug Aricept also does, say University of Massachusetts researchers.
Jean Carper: In Honor of World Alzheimer's Day, Take a Hike Today
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Scopolamine and hyoscyamine are most concentrated in the seeds and can cause anticholinergic poisoning in exposed persons.
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Elderly patients should not be treated with tertiary amines because of the greater anticholinergic effects of these agents.
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Sage oil inhibits an enzyme called acetylcholinesterase, whose normal job is to break down the chemical messenger acetylcholine.
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Similar studies need to be done to evaluate the role of the cholinergic nerves in the gastric response to intragastric ethanol.
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In the review by Trollor and Sachdev, a muscle relaxant was used in 50% of the cases with succinylcholine being the most common.
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Tracheal intubation was performed after the administration of succinylcholine intravenously.
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They dismiss conventional medical treatment with anticholinergic drugs as inconvenient, unpleasant, and temporary, and they say that patients usually stop using anticholinergic drugs because of a dry mouth.
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In the same paper I had speculated on the possible occurrence of acetylcholine in the animal body, and on its physiological significance if it should be found there; and had pointed out the extraordinary evanescence of its action, suggesting that an esterase probably contributed to its rapid removal from the blood.
Sir Henry Dale - Nobel Lecture
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They can sometimes be controlled by anticholinergic or antiparkinsonian medications.
Law In The Health and Human Services
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Low levels of choline in the body can give rise to high blood-pressure.
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The action of a common neurotransmitter, such as acetylcholine, illustrates how ion channel receptors work.
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It's use to make the nerve transmitter chemical called acetyl choline that many of our nerves and our brain and our muscles use to send messages.
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In 1940, curare was introduced to moderate the vertebrae-cracking force of the convulsions, and succinylcholine was introduced in 1952.
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Low levels of choline in the body can give rise to high blood-pressure.
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A man takes three sips of kalla, and he touches off the release of neurotransmitters, acetylcholine and tryptamine and serotonin.
THE BROKEN GOD
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This inhibition was observed in both the directly and indirectly stimulated contractions, and was not changed by addition of neostigmine, an acetylcholine esterase inhibitor.
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The release of acetylcholine stimulates three types of muscarinic receptors, M1 - M3, to produce bronchoconstriction and mucous secretion.
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And some research suggests that the drugs — memantine (Namenda), and cholinesterase inhibitors such as donepezil (Aricept and generic) and galantamine (Razadyne and generic) — may be more effective when taken together.
Brain boosters in a bottle?
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Botulism toxin from bacteria prevents the release of acetylcholine and is the most poisonous substance known.
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This agent crosses the blood-brain barrier and thereby reverses both central and peripheral effects of the abused anticholinergic drug.
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Taking phosphatidylcholine, plus oleic and linoleic acid, helps to maintain water in the cells of the skin.
Times, Sunday Times
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The acetylcholine sweat spot test is an easy, inexpensive, time saving test for detecting autonomic neuropathy.
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Briefly, cholesterol, phosphatidylethanolamine and phosphatidylcholine (all from Sigma) were dissolved in chloroform at a concentration of 10 mg / mL.
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Treatments for early, mild Alzheimer's disease, such as donepezil, improve the activity of neurons in the cholinergic system that use acetylcholine to transmit signals.
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Acetylcholine is released by neurons to provoke muscle contraction.
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As expected, the inward currents elicited by carbachol (1 mM, 30 s) persisted for a longer duration compared to the inward currents elicited by acetylcholine (1 mM, 30 s) in both males and females, as seen in the voltage clamp traces in
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But they slow mental deterioration by blocking the breakdown of the brain chemical acetylcholine.
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We have evidence, then, that both the reserve of acetylcholine, and the esterase required for its destruction, are in fact associated with the preganglionic nerve endings, as our hypothesis demands.
Sir Henry Dale - Nobel Lecture
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MAIN OUTCOME MEASURES: Determination of the choline acetyltransferase activity in the groups.
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The sex difference persisted when the nicotinic receptors were activated with carbachol, an analogue of acetylcholine that is not broken down by endogenous acetylcholinesterase.
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Sir Bernard Katz 'discoveries concerning the mechanism for the release of the transmitter acetylcholine from the nerve terminals at the nerve-muscle junction, under the influence of the nerve impulses, are fundamental not only for the understanding of the so-called cholinergic transmission, but are also of primary importance for our knowledge about the synaptic transmission between the nerve cells in the central nervous system.
Physiology or Medicine 1970 - Press Release
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In contrast, choline is essentially derived from the circulation, and only negligible amounts are incorporated into other lipids, such as sphingomyelin.
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Feldberg and Gaddum17, though unable to reproduce effects obtained by Kibjakow with pure Locke's solution, found that, when eserine was added to the fluid perfusing the ganglion, stimulation of the preganglionic fibres regularly caused the appearance of acetycholine in the venous effluent.
Sir Henry Dale - Nobel Lecture
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They recommend anticholinergics and antihistamines for the treatment of nausea associated with vertigo or motion sickness.
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Cholinesterase inhibitors, which reduce cholinesterase - the enzyme that breaks down acetylcholine - are the only FDA-approved treatment for Alzheimer's.
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We collaborated with my good friend William Sleator of the Physiology Department in the study of changes in cellular action potentials (measured with intracellular microelectrodes) associated with the changes in contractility of the guinea pig atrium in response to epinephrine and acetylcholine, and a number of other inotropic agents.
Robert F. Furchgott - Autobiography
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Probably the most common medications used for the treatment of incontinence fall into the general category of anticholinergics or drugs designed to ‘relax’ the bladder.
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Researches also show that Epimedium can inhibit an enzyme called acetylcholinesterase
Xml's Blinklist.com
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Use of the anticholinergic drug atropine during tap-water iontophoresis sometimes is helpful, but extreme caution is necessary to avoid toxicity from atropine overdose.
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The accidental finding was that on the preparation of rabbit aorta being used in the experiment, the muscarinic agents acetylcholine and carbachol induced relaxation rather than the expected contraction.
Robert F. Furchgott - Autobiography
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These include the biosynthetic pathways for creatine, epinephrine, phosphatidylcholine, and the methylation of DNA and RNA.
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Tim Foley Alzheimer's disease is often treated by a class of drugs called cholinesterase inhibitors, which help boost levels of a brain chemical called acetylcholine.
Drug Cocktail May Slow Alzheimer's
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The disease-induced destruction of these cells, which are called "basal forebrain cholinergic" BFC neurons, is key to the progression of Alzheimer's.
Yahoo! News: Business - Opinion
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The idea is the turn up the volume of neuronal signals that use acetylcholine as a transmitter molecule, by inhibiting the enzyme that would break it down and sweep it out of the synapse.
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Most of the clinically significant symptoms of dissociatives are produced by presynaptic dopamine stimulation and cholinergic antagonism.
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(D-I) The diaphragms of wild-type (D-F) and meltrin β − / − (G-I) mice at E18. 5 were stained with an anti-synaptophysin antibody (D and G) to label axon terminals and with BTX (E and H) to label acetylcholine receptors (AChRs).
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Current treatment involves the use of drugs such as donepezil, tacrine, rivastigmine, galanlamine etc which act as choline esterase inhibitors.
Remembering Dr. Alois Alzheimer
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Light anesthesia is induced using a short-acting barbiturate, usually methohexital IV followed by succinylcholine IV for muscle relaxation.
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Evidence from both species supports the conclusion that the excitation derives from glutamatergic premotor interneurones and cholinergic homonymous motorneurones.
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It is rich in phosphatidyl choline, phosphatidylethanolamine, and phosphatidyl inositol.
The New Super-Nutrition
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Temburni, MK, et al. Receptor Targeting and Heterogeneity at interneuronal nicotinic cholinergic synapses in vivo.
T.S. Wiley: Estrogen Dilemma: There Is No Dilemma When You Know the Details
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Normally, at these nicotinic synapses, the transmitter is rapidly destroyed by the enzyme cholinesterase, so its action is evanescent; this is not the case with nicotine.
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In the study, it was found that DEET blocked the enzyme cholinesterase, which is essential for transmitting messages from the brain to the muscles, in experiments done on rodents using an amount of DEET equivalent to that used by humans.
Livescience.com
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Enzyme kinetics investigation revealed that the affinity of gut carboxylesterase of Periplaneta americana (L. ) for dipterex was 23 times greater than that with the cholinesterase.
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Neuronal Transmission, Cellular Excitability, and Calcium Signaling The many markers involved in the assembly, function and / or regulation of neurotransmitter receptors, included several related to peptidergic, aminergic, and cholinergic signaling, and suggested that HVC is a major target of neuromodulation by these pathways (
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Note: Fexofenadine (Allegra) and cetirizine (Zyrtec) are antihistamines without anti-cholinergic effects, but may cause sedation.
Leo Galland, M.D.: Over-The-Counter Drugs That Can Cause Memory Loss
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Whereas the anticholinesterase compounds, which have high acute toxicity (and hence are highly hazardous to the applicator), are readily and rapidly degraded in nature, the halogenated hydrocarbons are not.
Rachel Carson’s Victims, R.I.P.
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anticholinergic drugs
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"Choline salts have been known to produce an offensive, fishy body odor, " says Wright.
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There's a somewhat shady treatment called mesotherapy which involves an injection of something called phosphatidylcholine, a purported fat-dissolver.
Leslie Goldman: $18 Million Plus Our Collective Souls to Anyone who Can Cure Cellulite
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An early favorite target was the vital enzyme acetylcholinesterase, required for hydrolysis of acetylcholine at neuromuscular junctions, and it has been exploited by agrochemical companies in a spectacular manner.
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Until further research in primary care settings is performed, there is little evidence to guide family physicians in the choice of anticholinergic medications for urge incontinence.
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Two kinds of motor nerves, excitatory nerves that release acetylcholine and inhibitory nerves that release nitric oxide, account for all events that occur in smooth muscle of the esophagus in a swallow.
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The UN team concluded from them that the patients had been exposed to an anticholinesterase agent "- nerve gas. (
WHAT REALLY HAPPENED
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Anti-cholinergic drugs, such as ipratropium bromide dilate airways.
CreationWiki - Recent changes [en]
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However, the effect of chronic treatment with anticholinergics on airway remodeling, responsiveness, and changes in lung function in patients with asthma is thus far unclear.
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He identified acetylcholine as a constituent of certain ergot extracts, and an analysis of its action served as a basis for later researches, extending the application of Loewi's discoveries, which have been recognized in the joint award of the
Sir Henry Dale - Biography
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The patient is then closely observed for muscle fasciculations representing the first depolarization phase of succinylcholine activity.
The Neuropsychiatric Guide to Modern Everyday Psychiatry
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Prior to the introduction in 1955 of succinylcholine muscle relaxation for ECT, many patients sustained spinal compression fractures during the tonic phase of the induced seizure, and pretreatment x-rays of the dorsolumbar spine were routinely obtained for medicolegal documentation.
The Neuropsychiatric Guide to Modern Everyday Psychiatry
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For many patients the onset of EPS is gradual, and if it occurs, can be treated with anticholinergic medication.
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A striking increase in cell invasiveness was observed once the cells were treated with the bioactive lipid sphingosylphosphorylcholine (SPC) that leads to a reorganization of the cell's keratin network, an enhancement of the cell's deformability, and also an increase in the cell's migration speed on flat surfaces.
Elites TV
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The symptoms of anticholinergic overdose may be treated with physostigmine in a dosage of 1 to 2 mg given intramuscularly or intravenously at 20-minute intervals.
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In that same year, W. B. Cannon found an accelerator substance released by the sympathetic nerves, and called it sympathin.5 It was later shown by U.S. von Euler to be a combination of epinephrine and a similar substance called norepinephrine.6 Cannon went on to characterize the function of the sympathetic (norepinephrine) and parasympathetic (acetylcholine) divisions of the autonomic nervous system.
Alcohol and The Addictive Brain
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The pseudocholinesterase activity after adsorption was almost 3 fold compared with before adsorption.
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If these measures are not successful, an anticholinergic drug may control the pain.
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These "anticholinergic" medications include some older antidepressants like Elavil, as well as some antihistamines, painkillers, muscle relaxants, antispasmotics and incontinence drugs.
'Neurobics' and Other Brain Boosters
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*hauls in ginormous tray loaded with bowls of salted almonds, picholine olives, and fresh mozzarella, gorgonzola picante, and thinly-sliced breads.
Dis poor subztidute - Lolcats 'n' Funny Pictures of Cats - I Can Has Cheezburger?
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Considering the manner in which acetylcholine must reach the motor end plates of the muscle fibres, if it were indeed the transmitter of motor nerve excitation - that it must appear with a flash-like suddenness, in high concentration, simultaneously at every nerve ending - we concluded that the ordinary method of injecting acerylcholine, so that it reached the muscle by slow diffusion from the general circulation, could not possibly reproduce this abrupt appearance at the points responsive to its action.
Sir Henry Dale - Nobel Lecture
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Bacq and Brown22 have more recently extended these observations to a series on artificial eserine analogues, and have found that the potentiating action on the response of mammalian muscle to single nerve volleys is, in fact, proportional, in the different compounds of the series, to the anticholinesterase action, as independently determined.
Sir Henry Dale - Nobel Lecture
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If the memory loss is severe enough to warrant a diagnosis of dementia, then cholinesterase inhibitor therapy would be indicated.
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Succinylcholine is used in intensive care wards, usually to assist the insertion of a tracheal tube.
Times, Sunday Times
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The eserine has so depressed the action of the esterase at the nerve endings, that the acetylcholine liberated by a single nerve volley lingers there, and reexcites the muscle at each emergence from successive refractory periods, until the concentration falls at last below the stimulation threshold.
Sir Henry Dale - Nobel Lecture
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We also learn about cholinergic and aminergic systems and many other things that are not found by my computer's artificially intelligent English spell-checking system-or referenced again by the author.
Adrian Monck
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The active ingredients in this were alkaloids of belladonna, which we now know had the effect of inhibiting cholinergic neurotransmission and thereby reflex bronchoconstriction.
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We showed that the positive inotropic effects of norepinephrine and strophanthin-K were correlated with an increase in rate of exchange of calcium in an intracellular pool associated with the contractile process and that the negative inotropic effects of acetylcholine and adenosine were correlated with a decrease in rate of exchange in that pool.
Robert F. Furchgott - Autobiography
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All nerve agents act by inhibiting the enzyme acetylcholinesterase, which breaks down the neurotransmitter acetylcholine.
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Short-term use of anticholinergics or antidiarrheal agents may be effective in combating incontinence associated with diarrhea.
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The administration of succinylcholine results in transient and modest increases in intracranial pressure.
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These people also had high levels of two chemicals: myoinositol/creatine and choline/creatine.
Sophisticated scan may spot seeds of Alzheimer's risk
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Current treatment involves the use of drugs such as donepezil, tacrine, rivastigmine, galanlamine etc which act as choline esterase inhibitors.
Remembering Dr. Alois Alzheimer
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These drugs are called anticholinergics and include oxybutynin, tolterodine, trospium chloride, and propiverine.
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Therapeutic trials include those with proton pump inhibitors, prokinetic agents, mucosal protectants, anticholinergics and low-dose antidepressants.
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Choline chloride and phosphatidylcholine, which are orally bioavailable precursors of acetylcholine, have been reported to be useful in short-term studies.
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Thus, in 1914, anticholinergics by injection or inhalation were considered as first-line asthma therapies.
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However, acetylcholine, the first neurotransmitter to be identified, was not isolated until the early 1920s.
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In the absence of acetylcholinesterase, levels of the transmitter acetylcholine increase.
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He thought for a minute and added, ‘So, if we improve cognition by increasing acetylcholine, it makes sense that anticholinergic drugs can make dementia a lot worse.’
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Amniotic fluid acetylcholinesterase is found in gastroschisis but not omphalocele.
CHOP abdominal wall defect publications
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Metoclopramide sensitizes tissues to acetylcholine to stimulate upper GI tract motility without stimulating gastric, biliary, or pancreatic secretions.
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Comparison of real and simulated acupuncture and isoproterenol in methacholine-induced asthma.
The Best Alternative Medicine
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Although statistically significant, the differences between anticholinergic drugs and placebo were small, apart from the increased rate of dry mouth in patients receiving active treatment.
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We examined the effects of solutions containing miotic agents such as carbachol and/or acetylcholine on corneal endothelial pumping activity.
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Nonpolarizing neuromuscular blocking agents such as succinylcholine can cause fasiculations, which are vaguely convulsive, but that is why polarizing agents such as rocuronium are used to suppress fasiculations, which can interfere with tracheal intubation (i.e., inserting a breathing tube).
Citizendium, the Citizens' Compendium - Recent changes [en]
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Available cholinesterase inhibitors drugs are donepezil, galantamine, rivastigmine, and tacrine. antipsychotic agents (olanzapine, quetiapine, risperidone), were found to have "adverse effects offset advantages in the efficacy of atypical antipsychotic drugs for the treatment of psychosis, aggression, or agitation in patients with Alzheimer's disease.
Citizendium, the Citizens' Compendium - Recent changes [en]
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The suspect compounds, known as cholinesterase inhibitors, aren't normally toxic at low levels.
Poisoned In The Gulf?
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There is no doubt that choline and its cousins are related to memory.
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THC has been found to prevent an enzyme called "acetylcholinesterase" from producing Alzheimer's plaques in the brain and is found to be effective in blocking protein clumps that inhibits memory and cognitive thinking in Alzheimer's patients.
Vault9.net
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The most common neurotransmitter is called acetylcholine.
You Staying Young
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In the brain, it impersonates the neurotransmitter acetylcholine and binds with a subtype of acetylcholine receptor called the nicotinic receptor.
Globe and Mail
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Forensic tests indicate he was first injected in the thigh with a fast-acting muscle relaxant called succinylcholine, which is said to be hard to detect.
The Seattle Times
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Hornberg A, Tunemalm AK, Ekstrom F (2007) Crystal structures of acetylcholinesterase in complex with organophosphorus compounds suggest that the acyl pocket modulates the aging reaction by precluding the formation of the trigonal bipyramidal transition state.
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“Responses of a Molluscan Smooth Muscle to Acetylcholine and 5-hydroxytryptamine.”
MANUFACTURING DEPRESSION
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In patients with chronic hypoxemic lung disease, polycythemia has been shown to impair the vasodilator response to acetylcholine.
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Chain perdeuterated dimyristoylphosphatidylcholine was synthesized from perdeuterated myristic acid by acylation of glycerophosphocholine, as described previously.
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Then we move on to the bread service, where I chose a picholine olive mini-baguette served along with their unsalted butter.
The Wandering Eater
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It is known that metal cations form complexes with anionic phosphodiester groups and carbonyl oxygens in the glycerol backbone of phosphocholine lipids.
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Currently, a class of drugs called cholinesterase inhibitors are widely used to treat Alzheimer's patients,
Medlogs - Recent stories
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Acetylcholine acts as a transmitter between motor nerves and the fibres of skeletal muscle at all neuromuscular junctions.
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The inhibitor of nitric oxide synthase failed to inhibit this response, and it also did not potentiate the reflex cholinergic contractions of the trachea produced by bradykinin.
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Even when obtained in solution this potent enzyme destroys acetylcholine with a quite remarkable rapidity; and if we could suppose it to be concentrated on surfaces at preganglionic or motor nerve endings, in immediate relation to the site of liberation and action of acetylcholine, it might furnish an adequate mechanism for the complete destruction of this substance, even during the very brief interval of the refractory period.
Sir Henry Dale - Nobel Lecture
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Current treatment involves the use of drugs such as donepezil, tacrine, rivastigmine, galanlamine etc which act as choline esterase inhibitors.
Remembering Dr. Alois Alzheimer
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The EFS was applied under NANC conditions (in the presence of atropine (1 µM) and guanethidine (5 µM)) to block cholinergic and adrenergic responses to elicit nonadrenergic noncholinergic inhibitory responses.
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Positive or faint amniotic fluid acetylcholinesterase band with normal ultrasound.
Prenatal Diagnosis
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The application of this methodology to biological systems has allowed the generation of biologically active substances, in particular enzyme inhibitors (carbonic anhydrase, acetylcholine esterase).
Jean-Marie Lehn - Autobiography
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John Garthwaite had just reported that nitric oxide was a neuro transmitter in the brain, and we wondered whether or not nitric oxide could be the neurotransmitter in the so called nonadrenergic noncholinergic neurons that were known to innervate the corpus cavernosum smooth muscle.
Louis J. Ignarro - Autobiography
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The active ingredients in this were alkaloids of belladonna, which we now know had the effect of inhibiting cholinergic neurotransmission and thereby reflex bronchoconstriction.
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Treatment: Allergy shots and antihistamines don't help, but nasal steroid sprays, anticholinergic inhalers, masks and breathing exercises may provide relief.
Adult Mystery: Sudden 'Allergy'
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This analeptic effect of MAP was blocked by atropine but not by atropine methylbromide, indicating the central cholinergic nature of the response.
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However, these patients are prone to ileus formation secondary to the anticholinergic effects of glutethimide.
Loads
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1967: Researchers paralyze 64 prison inmates in California with a neuromuscular compound called succinylcholine, which produces suppressed breathing that feels similar to drowning.
WHAT REALLY HAPPENED
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You will see that we are thus led to the conclusion that nearly all the efferent neurones of the whole peripheral nervous system are cholinergic; only the postganglionic fibres of the true sympathetic system are adrenergic, and not even all of these.
Sir Henry Dale - Nobel Lecture
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Maloney KJ, Mainville L, Jones BE (1999) Differential c-Fos expression in cholinergic, monoaminergic, and GABAergic cell groups of the pontomesencephalic tegmentum after paradoxical sleep deprivation and recovery.
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Lecithins such as phosphatidylcholine can act as emulsifiers, which stabilize mixtures of substances that would otherwise separate.
AlterNet.org Main RSS Feed
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Medical management consists of maintenance therapy with anticholinergic inhibitors such as pyridostigmine to relieve symptoms and steroids to treat the autoimmunity.
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Depolarization of the presynaptic membrane causes release of acetylcholine into the synaptic cleft.
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The nerve gases that have been developed for warfare are known as "anticholinesterase agents.
WHAT REALLY HAPPENED
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Largely because the anticholinesterase nerve agents produce a unique and striking pattern of symptoms.
WHAT REALLY HAPPENED
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A mainstay of treatment for Alzheimer's is a class of drugs called the cholinesterase inhibitors.
BBC News | News Front Page | World Edition
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New medications, particularly anticholinergics and psychotropic medicines, should be the first suspects if there is a change in a patient's mental status.
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Instead the acetylcholine accumulates and affects both voluntary an involuntary muscles.
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Tiotropium is in a class of drugs called anticholinergic bronchodilators, which prevent the airway spasms that can make breathing difficult.
Medlogs - Recent stories
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In bars and restaurants, spirits get infused with everything from ginger to sausage to picholine olives.
Serious Eats: New York
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He starts with a mixture of olives such as kalamata, Nicoise, Arbequina, Cerignola, picholine and oil-cured black olives.
TheState.com: The Buzz
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Folic acid, biotin, and choline also belong to the B group but do not have numbers.
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Vasodilators, such as acetylcholine and bradykinin, do not exert their effects upon the vascular smooth muscle cell in the absence of the overlying endothelium.
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Reduces the natural relaxation and anti-inflammatory calming, memory-enhancing neurotransmitter called acetylcholine.
The UltraMind Solution
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Older men with prostatic hypertrophy may benefit from alpha-blocker medications and should be watched for urinary retention if anticholinergic drugs are employed.
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ATLANTA, Feb. 4 (UPI) -- Health officials should be aware of the signs of anticholinergic toxicity and consider jimsonweed poisoning as a cause of illness, U.S. health officials say.
Latest News - UPI.com
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'There are also drug treatments such as anticholinergic medicines, which stop the bladder from going into spasm,' she says.
Home | Mail Online
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Fleisher JH, Harris LW, Murtha EF (1967) Reactivation by pyridinium aldoxime methochloride (PAM) of inhibited cholinesterase activity in dogs after poisoning with pinacolyl methylphosphonofluoridate (soman).
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As mentioned in the discussion of pathophysiology, their beneficial effect is mainly due to the blocking of striatal acetylcholine receptors.
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Postganglionic parasympathetic nerves mediate both cholinergic contractions and nonadrenergic, noncholinergic relaxations of smooth muscle in the airway.
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Ingestion of Ipomoea muricata (purple moonflower) might cause hallucinations and cholinergic effects such as diaphoresis, salivation, lacrimation, and diarrhea.
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The membrane models used for this study are equilibrated fully hydrated dimyristoyl-phosphatidylcholine bilayers.
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Trichlorfon use is broadly based on its action as an inhibitor of acetylcholine esterase.
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In experiments with the new material it defended completely against Staph and E. Coli infections and within 24 hoursit restored 70% of acetylcholinesterase — a bodily enzyme that is attacked by nerve agents.
Combating Terrorism with an Environmentally Friendly Polymer | Inhabitat
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These studies indicate that the protein exhibits highest selectivity for the choline phospholipids phosphatidylcholine and sphingomyelin under physiological conditions of pH and ionic strength.
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A neurotransmitter such as acetylcholine is responsible for allowing nerve impulses to jump across a gap between two nerve cells in the brain called synapse.
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Memantine is intended to treat moderate to severe Alzheimer's, but it is frequently used in mild Alzheimer's patients "off-label" - for uses other than those approved by the Federal Drug Administration - either alone or in combination with a drug known as a cholinesterase inhibitor.
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The dish: a roasted sea scallop with serrano ham, braised oxtail, picholine olives, sweet garlic purée and crispy artichokes.
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The responsible nerves appear to include both excitatory cholinergic fibers and inhibitory fibers that probably release nitric oxide.
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Examples of anticholinergic drugs include atropine and ipratropium (Atrovent).
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The most typical side effect of anticholinergics is dry mouth; other side effects include blurred vision, constipation, nausea, dizziness, and headache.
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And he serves a Florida grouper, carefully grilled and garnished with quinoa, green beans, picholine olives, Speck ham and cherry tomatoes.
New York Eateries Hit the Beach
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Concomitant use of anticholinergics and beta 2 agonists may be beneficial to the older patient
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Loewi named the substance released by the relevant nerve, called the vagus nerve, Vagusstoff; today it is known as the neurotransmitter acetylcholine.
How the Mind Works: Revelations
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This difference has caused some people to prefer to speak of acetylcholine as a neurohumor, "humor" being an old-fashioned medical term for a biological fluid (from a Latin word for "moisture").
The Human Brain
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The acetylcholine binding site at atomic resolution has five aromatic amino acids.
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We measured the tracheal smooth muscle reactivity to methacholine.
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Janda said, "we found that thc was a very effective inhibitor of acetylcholinesterase. in addition to propidium, we also found that thc was considerably more effective than two of the approved drugs for alzheimer's disease treatment, donepezil (aricept ®) and tacrine (cognex
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The above results suggest that the inhibitory effect of centrally administrated HA on gastric acid secretion is mediated by vagi , acetylcholine M receptor and somatostatin.
