How To Use Cd4 In A Sentence
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Areas of laboratory research interest include immune cell (T -, B -, NK-cell) signal transduction and cytoskeletal dynamics, dendritic cells and immune tolerance infectious causes of autoimmune disease and CD40-ligand transcriptional and post-transcriptional regulation in SLE.
Pediatric Rheumatology Fellowship
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Antibody levels and percent survival of BALB / c mice immunized and depleted / undepleted of CD4
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In dermatology field, the interaction of CD40-CD40L is involved in the occurrence and development of immunologic, inflammatory, infectious and tumorous dermatoses .
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Five patients had an initial rise of CD4 and CD8 cell counts during the first week of illness, followed by a fall of both cell counts.
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To investigate thrombocyte and erythrocyte CD35, CD44 and CD62P expression discrepancy and its biological significance of tumor metastasis.
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Officials at the National Institutes of Health and the Atlanta-based Centers for Disease Control have dubbed the phenomenon ICL (for idiopathic CD4 + T-lymphocytopenia), and scientists are searching for common threads among sufferers.
Aids Or Chronic Fatigue?
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They not only found that large numbers of CD8+ T cells infiltrated obese epididymal adipose tissue in mice fed a high-fat diet (while there was a depletion of CD4+ T ells), but also that this infiltration preceded the accumulation of macrophages in fat tissue.
Dr. Sharma’s Obesity Notes » Blog Archive » Will Immunotherapy Provide a New Treatment for Obesity?
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Specifically, the flow cytometer told Gilbert that in the mice exposed to TCE, a T-cell activation molecule, CD44, was acting differently than it would have if there had been no autogen.
The Autoimmune Epidemic
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It is a physiological way of preventing abnormal proliferation of activated lymphocyte clones, but here the phenomenon was enormous and bore not only on the main cellular target of HIV infection, CD4+ T-lymphocytes, but also on cells which were not infectable by the virus, such as CD8+ T-lymphocytes, B-lymphocytes, monocytes, natural killer cells ...
Luc Montagnier - Autobiography
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Influenza vaccination has produced substantial antibody titers against influenza in vaccinated HIV-infected persons who have minimal symptoms related to acquired immunodeficiency syndrome and high CD4 cell counts.
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Through cell culture and mouse experiments, the researchers found that a protein called thrombospondin-1 (TSP1) and its receptor, CD47, inhibit activation of the endothelial-based enzyme called endothelial nitric oxide synthase (eNOS), which in turn limits the production of
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CD4 is a receptor for HIV in humans
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Meanwhile, my co-workers showed the tropism of the virus for CD4T cells and identified the CD4 surface molecule as the main receptor to the virus.
Luc Montagnier - Autobiography
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cd4e repair manuel: Actually, Manuel usually works on exhaust systems; we assign the transmission work to Paco.
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After washing with a staining buffer, cells were incubated with anti-mouse CD16/32 (Fc block, e-Bioscience) for 30 min on ice to block the FcR non-specific binding and subsequently stained for surface markers with PE-anti-CD4, FITC-anti-CD3ε, PerCy-anti-CD8 or isotype controls for
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In addition, FACS analysis of thymocytes derived from TetO-Dkk1 and K5rtTA-ST mice following 4 weeks of Dox feeding using antibodies against CD4, CD8, TCRβ, CD25 and CD44 was used to assess differences in thymocyte subset frequency.
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It is a physiological way of preventing abnormal proliferation of activated lymphocyte clones, but here the phenomenon was enormous and bore not only on the main cellular target of HIV infection, CD4+ T-lymphocytes, but also on cells which were not infectable by the virus, such as CD8+ T-lymphocytes, B-lymphocytes, monocytes, natural killer cells ...
Luc Montagnier - Autobiography
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The research also shows that most normal cell populations don't display calreticulin and are, therefore, not depleted when we expose them to a blocking anti-CD47 antibody.
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Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, et al. (2000) B7 / CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
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A. agrarius mice express novel CD46 transcripts, resulting in the trade of spermatozoal CD46 protein expression for a rapid acrosome reaction rate, in common with other species of field mice.
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Stem-cell-enriched CD49f hi cells amplify at dioestrus, or with exogenous progesterone, demonstrating a key role for progesterone in propelling this expansion.
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This, in turn, renders cells refractory to subsequent infection by the same or other viruses that use the CD4 receptor for entry; thus creating a state of super-infection immunity.
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The baboons became infected with the virus and four of the baboons developed lymphadenopathy and three of the animals exhibited CD4 T-cell loss within nineteen to twenty-four months after inoculation.
'The AIDS Heresy': Another Exchange
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This research demonstrates that the reason that blocking the CD47 'don't eat me' signal works to kill cancer is that leukemias, lymphomas and many solid tumors also display a calreticulin
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The combination therapy of one protease inhibitor and two nucleoside transcriptase inhibitors has markedly increased the number of CD4 cells and decreased the viral load of patients.
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Today the company said it is expanding its immunotherapy platform by acquiring exclusive rights to immune-modulating molecules known as FMS-like tyrosine kinase 3 ligand (Flt3L) and CD40 ligand (CD40L), from
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P570-expanded CD4+CD25+ T cells suppress diabetes development in cotransfer models
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In addition, A. agrarius CD46 transcripts have an extended AU-rich 3'-untranslated region (UTR) and a truncated 5'-UTR, resulting in failure to express spermatozoal CD46 protein.
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Removing CD4 from the cell surface prevents superinfection (more than one virus infecting the same cell) and helps prevent newly released viruses from turning around and infecting the same cell (also prevented by an HIV maturation step involving protease).
ERV & HIV versus Behe. Behe loses. - The Panda's Thumb
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Prototype for the CD4 analyzer and biochip sensor.
Handheld Puts AIDS Fight in Field (Wired News)
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Michaelsson J, Barbosa HM, Jordan KA, Chapman JM, Brunialti MK, et al. (2008) The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis.
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The negative controls used were spleens and thymi from non-GFPtg-nursed B6 mice, and the positive controls used were spleens and thymi from GFPtg mice. *, p FACS analysis interestingly and clearly showed that CD4+ cells preferentially migrated to the spleen (
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Michaelsson J, Barbosa HM, Jordan KA, Chapman JM, Brunialti MK, et al. (2008) The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis.
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Influenza vaccination has produced substantial antibody titers against influenza in vaccinated HIV-infected persons who have minimal symptoms related to acquired immunodeficiency syndrome and high CD4 cell counts.
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In rodents, the cell surface complement regulatory protein CD46 is expressed solely on the spermatozoal acrosome membrane.
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+ DC expressed costimulatory surface markers CD80 (65. 66% vs. 17. 43%), CD86 (57. 43% vs. 30%) and CD40 (44% vs. 35%) compared with iCD8
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Exposure to a metabolite of the environmental toxicant trichloroethylene attenuates CD4+ T cell activation-induced cell death by metalloproteinase-dependent FasL shedding.
The Autoimmune Epidemic
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Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey.
Stuck on you, biological Velcro and the evolution of adaptive immunity - The Panda's Thumb