NOUN
- any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active
How To Use zymogen In A Sentence
- Proteins in the stomach are broken down to polypeptides by the enzyme pepsin, which works best in acidic environments and is produced by ‘chief’, or ‘zymogen’, cells in the gastric mucosa.
- The broad spectrum serine protease plasmin is formed following cleavage of the zymogen precursor plasminogen by host activators tissue plasminogen activator and urokinase.
- Such differences among PC and other VKD proteins in charge distributions around the scissile bond may require different conditions for the initial approach of the zymogen to its enzyme for its activation.
- Still other proteins (of the enzyme class) are synthesized as inactive precursors called zymogens.
- One of the key reactions in the mammalian blood coagulation and hemostatic process is the cleavage of the zymogen prothrombin to thrombin which in turn activates fibrinogen to fibrin, eventually resulting in clot formation.
- Coagulation factors circulate as zymogens and platelet procoagulant surfaces are internalized.
- The cytoplasm contains numerous glycogen granules; however, zymogen and neurosecretory granules are absent.
- The proteases are secreted in forms of zymogen (ie, inactive precursor to enzyme), such as trypsinogen, chymotrypsinogen, and procarboxypeptidase.
- How this process occurs is unclear; however, it is believed that something activates the zymogens while they are still in the pancreas.
