NOUN
- periwinkle plant derivative used as an antineoplastic drug (trade name Oncovin); used to treat cancer of the lymphatic system
How To Use vincristine In A Sentence
- Adjuvant therapy, multidrug chemotherapy was carried out with methotrexate, cyclophosphamide, doxorubicin, vincristine, and prednisone.
- Past bioprospected compounds that received FDA approval include taxol, topotecan, vinblastine, vincristine, and irinocetan.
- In reality, more than 30% of conventional medications come from common plant sources (eg, digitalis from foxglove, vincristine from periwinkle).
- For the past decade, a modified chemotherapy regimen consisting of cyclophosphamide, vincristine, procarbazine and prednisone (COPP), together with adriamycin, bleomycin and vinblastine (ABV) has been used to treat patients with HD. Completed studies on late effects of childhood cancer
- Compared with CHOP -- cyclophosphamide, hydroxydaunorubicin, vincristine (Oncovin), and prednisone -- plus rituximab, the combination of bendamustine and rituximab showed substantially lower toxicity and better complete response rates in a randomized Phase III trial, reported Mathias Rummel, MD, PhD, of University Hospital in Giessen, Germany. MedPageToday.com - medical news plus CME for physicians
- Leukemia lines resistant to either doxorubicin, vincristine, methotrexate, or hydroxyurea were tested.
- Adjuvant therapy, multidrug chemotherapy was carried out with methotrexate, cyclophosphamide, doxorubicin, vincristine, and prednisone.
- The patient was treated per the hyper-CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) with intrathecal prophylaxis and achieved a complete remission.
- In any case, what he found was that treating two different leukemia and lymphoma cell lines with ascorbate at those concentrations before treating them with chemotherapeutic agents, including mechanistically dissimilar agents such as doxorubicin, which intercalates with DNA and causes DNA breaks; methotrexate, which inhibits folate metabolism; cisplatin, which crosslinks DNA; vincristine, which interferes with microtubule function; and imatinib mesylate (better known by its trade name of Gleevec), a selective inhibitor of the activity of a protein called bcr-abl, which is the oncogene that plays a central role in the development of chronic myelogenous leukemia (CML). Adrian Monck
- The patient was treated with a combined cyclophosphamide, vincristine, and prednisone chemotherapy regimen, resulting in a partial response.
