How To Use Trna In A Sentence
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Here, we describe the isolation and characterization of a unique tRNA-derived SINE family in dermopterans (flying lemurs or colugos).
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We also show that an active site cysteine is important for catalysis, likely in the protonation of uracil during tRNA reduction.
Journal of Biological Chemistry current issue
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Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea Rethinking screening
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Nine of the 11 positions between the coding region and the terminator, which is cleaved from the nascent transcript during tRNA maturation, are variable.
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In the echinoid gene order, the tRNA gene cluster follows the putative control region.
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Residues of these networking clusters are within van der Waals contact, and we suggest that they are critical in the propagation of long range mechanochemical motions in T. thermophilus leucyl-tRNA synthetase.
Journal of Biological Chemistry current issue
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In reality tRNAs contain acceptor stems at both their 3 'and 5' ends.
Analogy, How Scientifically Powerful is It?
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When the enzyme that adds the amino acid alanine to tRNAs - called alanyl-tRNA synthetase (AlaRS) - mischarges its tRNA (tRNA Ala), the error leads to the accumulation of misfolded proteins and the mice display severe neurological and other defects.
Health News from Medical News Today
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Yeah, a gradual, step by step development of DNA codons, mRNA, varieties of tRNA and amino acyl tRNA synthetases, and all that on route to a genetic code - now that's something to stick in your weed pipe.
Chunkdz Comes Out Smokin
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We present a phylogenetic analysis to determine whether a given tRNA molecule was established in evolution before its cognate aminoacyl-tRNA synthetase.
2008 October - Telic Thoughts
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Why the need for two intermediate components – the synthetase and the tRNA?
Signature in the Cell: self-contradiction and repetition - The Panda's Thumb
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His team boosted the pool of glycyl-tRNA, the major building block of spider silk protein synthesis.
EurekAlert! - Breaking News
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Glutaminyl-tRNA synthetase generates Gln-tRNA (Gln) 10 (7) - fold more efficiently than Glu-tRNA (Gln) and requires tRNA to synthesize the activated aminoacyl adenylate in the first step of the reaction.
Analogy, How Scientifically Powerful is It?
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Secondary absence of mitochondria in Giardia lamblia and Trichomonas vaginalis revealed by valyl-tRNA synthetase phylogeny.
Parasite Rex
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Using data recently obtained from the emerging genome projects, our analysis points to the extant forms of lysyl-tRNA synthetase being preceded in evolution by the establishment of the identity of lysine tRNA.
2008 October - Telic Thoughts
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When the enzyme that adds the amino acid alanine to tRNAs-called alanyl-tRNA synthetase (AlaRS) - mischarges its tRNA (tRNA Ala), the error leads to the accumulation of misfolded proteins and the mice display severe neurological and other defects.
PhysOrg.com - latest science and technology news stories
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The Alsophila cp genome shares some unusual characteristics with the previously sequenced cp genome of the polypod fern Adiantum capillus-veneris, including the absence of 5 tRNA genes that exist in most other cp genomes.
BioMed Central - Latest articles
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The Strnad team's discovery is close to last year's find by experts from the Czech Microbiology Institute who extracted a special substance, silybin, from a plant species, which prevents the development of blood vessels a tumour "attires" to nourish it.
Prague Monitor
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In this reaction, the rules of the genetic code are established by virtue of linking each amino acid with the tRNA that bears the cognate anticodon triplet.
Bits and Pieces of an RNA World
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A cold-trapping experiment revealed that the nonenzymatic rate of Gln-AMP hydrolysis is too slow to account for the rapid AMP formation; hence, the hydrolysis of Gln-AMP to form glutamine and AMP must be directly catalyzed by the GlnRS x tRNA (2'HGln) complex.
Analogy, How Scientifically Powerful is It?
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For the structures in figure 2 to form, complete individual tRNA gene transcripts are required.
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This strongly suggests that these tRNAs are edited by a mechanism similar to the one seen in the fungus Spizellomyces punctatus and the rhizopod amoeba Acanthamoeba castellanii.
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A cold-trapping experiment revealed that the nonenzymatic rate of Gln-AMP hydrolysis is too slow to account for the rapid AMP formation; hence, the hydrolysis of Gln-AMP to form glutamine and AMP must be directly catalyzed by the GlnRS x tRNA (2'HGln) complex.
Analogy, How Scientifically Powerful is It?
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Dimeric and trimeric tRNA-SINEs with identical subunits could be characterized in dermopterans (CYN-II, CYN-III, or t-SINE ).
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This hydrolysis of glutaminyl adenylate represents a novel reaction that is directly analogous to the pre-transfer editing hydrolysis of noncognate aminoacyl adenylates by editing synthetases such as isoleucyl-tRNA synthetase.
Analogy, How Scientifically Powerful is It?
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Just look at Asn-Asp and Gln-Glu tRNAs and their codon sequence with an understanding of charging proteins and the likely-hood of evolving similar shaped active sites and similar anti-codons.
The standard genetic code enhances adaptive evolution of proteins - The Panda's Thumb
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The earlier appearance of tRNA versus their metabolically related enzymes is a prediction of the RNA world theory, but the available synthetase and tRNA sequences previously had not allowed a formal comparison of their relative time of appearance.
2008 October - Telic Thoughts
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Here, an asymmetric pattern typical of differentiation is uncovered in the partition of the codon repertoire, as defined by the mechanism of aminoacylation of each corresponding tRNA.
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The anticodon contained in the tRNA determines which amino acid it will carry.
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Epub 2005 Apr 20. tRNA-dependent aminoacyl-adenylate hydrolysis by a nonediting class I aminoacyl-tRNA synthetase.
Analogy, How Scientifically Powerful is It?
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Lesser rearrangements, involving the reshuffling of tRNA genes, have been documented in honey bees, other hymenopterans, mosquitoes, collembolans, and an anostracan crustacean.
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We have reported recently that: (1) ribozymic precursors of the synthetases seem to have used the same two sterically mirror modes of tRNA recognition, (2) having these two modes might have helped in preventing erroneous aminoacylation of ancestral tRNAs with complementary anticodons, yet (3) the risk of confusion for the presumably earliest pairs of complementarily encoded amino acids had little to do with anticodons.
BioMed Central - Latest articles
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Aminoacyl-tRNA synthetase ribozyme, an example of the RNA-based catalysts that may have preceded protein enzymmes during the origin of life.
The Panda's Thumb: Prebiotic Chemistry Archives
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Unexpectedly, tracking of Gln-AMP formation utilizing an alpha-32P-labeled ATP substrate in the presence of tRNA (2'HGln) showed that AMP accumulates 5-fold more rapidly than Gln-AMP.
Analogy, How Scientifically Powerful is It?
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The "loaders" are special enzymes (aminoacyl tRNA synthetases).
PhysOrg.com - latest science and technology news stories
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Just look at Asn-Asp and Gln-Glu tRNAs and their codon sequence with an understanding of charging proteins and the likely-hood of evolving similar shaped active sites and similar anti-codons.
The standard genetic code enhances adaptive evolution of proteins - The Panda's Thumb
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Glutaminyl-tRNA synthetase generates Gln-tRNA (Gln) 10 (7) - fold more efficiently than Glu-tRNA (Gln) and requires tRNA to synthesize the activated aminoacyl adenylate in the first step of the reaction.
Analogy, How Scientifically Powerful is It?
