1. a set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's)
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How To Use secretase In A Sentence

  • I) or only the vasorin lumenal and transmembrane domains (Vas / Int J) were not substrates of γ-secretase. PLoS Biology: New Articles
  • Manfra D, Poulet FM, Zhang Q, Josien H, et al. (2004) Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. PLoS ONE Alerts: New Articles
  • Nicastrin binds to the amyloid-beta proteins, one in particular called amyloid precursor protein (APP), and then guides it to the gamma-secretase where the APP is then split in two; one half remains inside the cell and the other travels outside. Dallas Blog, Daily News, Dallas Politics, Opinion, and Commentary FrontBurner Blog D Magazine » Blog Archive » BIG NEWS ABOUT ALZHEIMER’S OUT OF UT SOUTHWESTERN
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