How To Use Rheumatoid In A Sentence

  • The new findings also may be important to people with systemic autoimmune disorders such as lupus or rheumatoid arthritis.
  • It can occur by itself or with other, common autoimmune diseases like rheumatoid arthritis and lupus.
  • Early in rheumatoid arthritis, joints in your wrists, hands, feet and knees are the ones most often affected.
  • This is probably what happens in rheumatoid arthritis, for instance. The Antioxidant Health Plan
  • The old kind -- filled with silicone gel -- were linked to debilitating health problems, so-called connective-tissue diseases such as lupus and rheumatoid arthritis. Health: New Year, New Breasts?
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  • Conditions such as an uncorrected fracture of the shin bone, rheumatoid arthritis, osteoarthritis or Paget's disease can distort the ends of the bones and cause knock knee in adults.
  • MF, Joosten LA, Abdollahi-Roodsaz S, van Lieshout AW, Sprong T, et al. (2005) The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. PLoS ONE Alerts: New Articles
  • That which medicine can't explain we tend to label psychosomatic and blame the patient, a cruel phenomenon all too familiar to those who've had MS, rheumatoid arthritis, and lupus, and a myriad of other ailments in decades past. John Falk: Chronic Fatigue Syndrome And Psychotherapy
  • In 1989, Tao administered an extract of the TCM antiarthritis herb T-2 Tripterygium wilfordii Hook F to 70 patients with rheumatoid arthritis of at least six months ’ duration which had not responded to standard treatment. The Best Alternative Medicine
  • The cervical spine in rheumatoid arthritis Needs careful assessment Rheumatoid arthritis commonly affects the cervical spine, causing several well defined deformities.
  • The criminal charge arose out of the fact that Vioxx had also been promoted as a treatment for rheumatoid arthritis before being officially approved.
  • An abnormally high count known as leukocytosis might indicate such conditions as leukemia, rheumatoid arthritis, tissue damage or infection. News
  • Typically, juvenile rheumatoid arthritis appears between the ages of 6 months and 16 years.
  • Among this latter group, there were four patients with rheumatoid arthritis, five with systemic sclerosis, three with systemic lupus erythematosus, five with dermatomyositis, and four with mixed connective tissue disease.
  • Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts. The Autoimmune Epidemic
  • As a child, I had watched my father suffer through a constellation of what I have since learned were autoimmune illnesses: inflammatory bowel disease, rheumatoid arthritis, and leucopenia. The Autoimmune Epidemic
  • It is also beneficial for rheumatoid arthritis sufferers. The Sun
  • Autoimmune disorders such as dermatomyositis, lupus or rheumatoid arthritis may produce characteristic rashes. We Blog A Lot
  • One option for those with rheumatoid arthritis is a therapeutic fast, which offers the body a chance to detoxify and gives it a break from food antigens that can cause joint inflammation.
  • Some time later I was asked to see a nun who had mild rheumatoid arthritis and well advanced osteoarthritis of both hips.
  • More serious is rheumatoid arthritis, where antibodies to antibodies are produced. The Family Nutrition Workbook
  • One of patients is a young woman forced to endure the pain and misery of rheumatoid arthritis. Times, Sunday Times
  • Often called "iritis," this condition tends to occur along with rheumatoid arthritis and other autoimmune diseases such as ulcerative colitis and Crohn's disease. RockyMountainNews.com
  • Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis. Leo Galland, M.D.: Why Medication Can Be Dangerous to Your Health
  • So far, the osteoarthritis clinic say my problem is probably rheumatoid and the rheumatoid docs say, no sounds more like osteo, and the gynae says no, it's torn muscles, and in the meantime I get better all by myself without any treatment except rest, while everyone argues. Archive 2007-10-01
  • The old kind -- filled with silicone gel -- were linked with debilitating health problems, so-called connective-tissue disorders, such as lupus and rheumatoid arthritis. New Year, Brand-New Breasts?
  • Applications: to chronic rheumatoid conditions and other inflammatory degenerative disease. The Dictionary of Modern Herbalism
  • The differential diagnosis of polymyalgia rheumatica includes malignancy, acute and chronic infections, thyroid disorders, depression, osteoarthritis, rheumatoid arthritis and polymyositis.
  • He also contributed to Charcot's classical study of tabes dorsalis published in 1868, which established the differential diagnosis between the arthropathies caused by rheumatoid arthritis and those associated with tabetic lesions.
  • Baltus B, Vondenhoff M, Huizinga TW, Tak PP, et al. (2007) Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis. PLoS ONE Alerts: New Articles
  • This may help ease pain suffered by people with inflammatory conditions such as rheumatoid arthritis. The Sun
  • Suppose Jane studys French and learns the meaning of the French word “arthrite”, namely a rheumatoid ailment that affects the joints only. Externalism About Mental Content
  • The classification criteria for rheumatoid arthritis are unhelpful in the early stages of the disease, but the need for disease modifying antirheumatic drugs can be accurately predicted by clinical and laboratory Latest headlines from BMJ
  • It can occur by itself or with other, common autoimmune diseases like rheumatoid arthritis and lupus.
  • The cervical spine in rheumatoid arthritis Needs careful assessment Rheumatoid arthritis commonly affects the cervical spine, causing several well defined deformities.
  • Indeed, rheumatoid factor testing is not useful when a patient lacks other diagnostic criteria for rheumatoid arthritis, especially synovitis.
  • The results also imply that statins could help treat rheumatoid arthritis and other auto-immune diseases.
  • I CAN'T work because of rheumatoid arthritis. The Sun
  • The new progress of rheumatoid arthritis on proteome achieved a great advance recently.
  • Objective To study the significance of α1 acid glycoprotein ( AAG ) on the activity of rheumatoid arthritis ( RA ).
  • This did happen whenever the authorities opened our RV refrigerator and saw the pre-packed syringes of my husband's rheumatoid arthritis medication. Bring medicine accross the board Laws
  • Rheumatoid nodules may also appear viscerally, such as on the pleura of the lung.
  • Because of its antiinflammatory action, feverfew is under investigation as a treatment for rheumatoid arthritis. Earl Mindell’s New Herb Bible
  • There is an association of retrocalcaneal bursitis with rheumatoid arthritis seen in up to 10% of patients with this disease.
  • The juice of the nettle is good, she says, for a variety of ailments - arthritis, rheumatoid arthritis, gout, allergic rashes and prickly heat.
  • Junta CM, Mello SS, Garcia PS, Rassi DM, et al. (2007) Profiling meta-analysis reveals primarily gene coexpression concordance between systemic lupus erythematosus and rheumatoid arthritis. PLoS ONE Alerts: New Articles
  • The wrist is often the first site of clinically detectable rheumatoid arthritis.
  • People with progressively severe impairments, due to illness such as multiple sclerosis or rheumatoid arthritis, must constantly cope with new problems.
  • Regular drinkers were 48 per cent less likely to be diagnosed with rheumatoid arthritis. The Sun
  • Defects of the hip's cartilage can be caused by osteoarthritis, rheumatoid arthritis, avascular necrosis, and trauma.
  • There an assessment nurse diagnosed an acute attack of rheumatoid arthritis and confirmed the diagnoses with blood tests for rheumatoid factor and ESR levels.
  • The report also recommends that people with progressive conditions, including rheumatoid arthritis, should be covered from the time of diagnosis.
  • SATURDAY, Nov. 5 HealthDay News -- Exposure to certain types of air pollution is associated with an increased risk for the painful joint disease known as rheumatoid arthritis, new research suggests. Yahoo! News: Business - Opinion
  • Rheumatic diseases such as rheumatoid arthritis, lupus, dermatomyositis, and scleroderma are thought to be autoimmune diseases.
  • The commonest causes of vasculitic ulcers are rheumatoid arthritis, systemic lupus, and polyarteritis nodosa.
  • In 2011, Biocon will scout for a global licensing partner not only for IN105, but also for its two other frontrunners: Anti-CD6, a drug for psoriasis and rheumatoid arthritis, and BVX- 20, for treating a common cancer of lymphoid organs. Deal Boost for Biocon
  • Rheumatoid arthritis produces synovitis and effusions but may lead to a valgus deformity.
  • Causes of arthritis can range from osteoarthritis, which is caused by deterioration of the cartilage that usually protects the bones from rubbing against each other, to rheumatoid arthritis, which is an autoimmune disorder where the body's immune system is overactive and attacking normal tissues. Dr. Andrew Lange: What to Do if You Have Arthritis, Part One
  • Rheumatoid arthritis (RA) (cont.) may not be good for us if we have circulatory problems or greatly restricted mobility. OUR BODIES, OURSELVES
  • By the same reasoning, proliferative vascular disorders such as retinopathy, psoriasis, and rheumatoid arthritis may worsen with proangiogenic therapy. The Scientist
  • But there's another type called rheumatoid arthritis RA, a serious autoimmune disease. The Full Feed from HuffingtonPost.com
  • Rim a person with rheumatoid arthritis?
  • Up to 60% of patients surveyed admitted the side effects of traditional medication for rheumatoid and osteo-arthritis were often worse than the symptoms.
  • A patient taking part in the trial of a drug for rheumatoid arthritis died of organ failure, an inquest was told. Times, Sunday Times
  • A review in 2002 of electrical stimulation research concluded that it can improve hand grip strength in patients with rheumatoid arthritis. Times, Sunday Times
  • In recent years, balneotherapy has served as one of the therapeutic alternatives in other rheumatoid diseases, particularly in chronic degenerative diseases. Recently Uploaded Slideshows
  • In 1977 my affliction was formally labeled a form of juvenile rheumatoid crippling arthritis.
  • As her severely rheumatoid hands are useless, an adequate range of movement in just one of her knees means that she can still get out of the chair without help.
  • Those who have rheumatoid arthritis may find it necessary to have regular eye examinations. The Medicine Chest - your family's guide to prescription drugs
  • Rheumatoid arthritis is a debilitating, chronic multisystem disease with an unknown etiology.
  • The group are at risk of blood sugar problems and are prone to allergic conditions such as asthma and rheumatoid arthritis. The Sun
  • Despite the increased difficulties, trials have been carried out on the effects of homoeopathy in a chronic condition - rheumatoid arthritis.
  • The commonest causes of vasculitic ulcers are rheumatoid arthritis, systemic lupus, and polyarteritis nodosa.
  • The physician also should ask if the patient has a history of gout, pseudogout, rheumatoid arthritis, or other degenerative joint disease.
  • We removed an aspergilloma located in the right lower lobe of the lung in a 48-year-old woman with a bronchial cyst and rheumatoid arthritis.
  • Examples of the latter include the connective tissue disorders including rheumatoid arthritis and systemic lupus erythematosus.
  • Depression has significant co-morbidity with illnesses associated with hypovitaminosis D such as osteoporosis, diabetes, heart disease, hypertension, multiple sclerosis, and rheumatoid arthritis. Therese Borchard: Vitamin D and Mental Health
  • The patient had rheumatoid arthritis, a condition associated with pyoderma gangrenosum.
  • Rheumatoid arthritis has also been linked with the virus.
  • A There are basically two kinds of arthritis - rheumatoid arthritis and osteoarthritis. Get the Best out of the Rest of Your Life
  • Regulation of interleukin-1beta-induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts. The Autoimmune Epidemic
  • For synovial diseases, such as pigmented villonodular synovitis, rheumatoid arthritis, and osteochondromatosis, it is desirable to remove as much of the synovium as possible.
  • Autoimmune diseases tend to run in families: Your grandmother might have rheumatoid arthritis, a cousin, vitiligo, and an aunt, sarcoidosis.
  • It has been used to treat rheumatoid arthritis for decades but not in its natural form. The Sun
  • His skin is pale and greyish, and his hands painfully contorted by years of rheumatoid arthritis.
  • A similar association that exists between psoriasis and cardiovascular disease is also found in cases of rheumatoid arthritis. Times, Sunday Times
  • Zacks analyst notes: Zalicus leading pipeline candidate is Synavive, a combination of the cardiovascular drug dipyridamole and an unconventionally low dose of the glucocorticoid steroid prednisolone, currently under mid-stage clinical development for the treatment of rheumatoid arthritis (RA) and osteoarthritis (OA). Zalicus: Ridiculously Cheap -- Seeking Alpha
  • Gold salts are highly effective in the management of patients with rheumatoid arthritis, most adverse reactions being mild and reversible.
  • This may help ease pain suffered by people with inflammatory conditions such as rheumatoid arthritis. The Sun
  • In the 1950s it was used in humans to treat rheumatoid arthritis and gout? Times, Sunday Times
  • And the arthritis isn't the typical osteoarthritis that strikes so many older people or the less-common rheumatoid arthritis that can cripple victims as young as six months.
  • Osteoarthritis, osteomalacia, rheumatoid arthritis, gout, and other arthritic conditions may increase the risk of problems originating from surgical positioning.
  • It is used in electronics and medicine, including treatment for rheumatoid arthritis. Times, Sunday Times
  • The extremities showed stigmata of rheumatoid arthritis with symmetrical swelling of the proximal interphalangeal joints and limited range of motion and swelling of the metacarpal phalangeal joints bilaterally.
  • It is also beneficial for rheumatoid arthritis sufferers. The Sun
  • It has been used to treat rheumatoid arthritis for decades but not in its natural form. The Sun
  • One hypothesis is that when these women were drinking coffee when they, were younger, the decaffeination process involved chemical solvents that have been implicated in connective-tissue diseases [like rheumatoid arthritis].
  • In the 1950s it was used in humans to treat rheumatoid arthritis and gout? Times, Sunday Times
  • There are perhaps up to 100 diseases where autoimmunity is involved in one way or other, including diabetes, multiple sclerosis and rheumatoid arthritis.
  • Objective:Sinomenine, a alkaloid monomer extracting from a plant Sinomenium acutum, has been used to relieve rheumatoid arthritis in human having well therapeutic effect and a few side effect.
  • So does chronic prostatitis go along with lupus or rheumatoid or MS or some of those other auto-immune diseases?
  • Oral methotrexate tablets are commonly used for the treatment of rheumatoid arthritis and severe psoriasis.
  • Rheumatoid arthritis is an inflammatory disease associated with increased microparticle production.
  • the specific target of the immune response in rheumatoid arthritis is filaggrin
  • The corticosteroids are a family of anti-inflammatory drugs, including hydrocortisone and prednisone, that are commonly used in the treatment of autoimmune and inflammatory diseases, such as asthma, rheumatoid arthritis, and ulcerative colitis. The World's Healthiest Foods
  • But what other employment lifestyle threatens Sudeck's atrophy, causalgia, stellate ganglion blockades, rheumatoid arthritis and systemic lupus while still bombarding you with offers for herbal Viagra?
  • Rheumatoid arthritis is a systemic inflammatory autoimmune disease of unknown cause.
  • Tests show blood rheumatism, lupus, rheumatoid arthritis, rheumatic fever, nervous rheumatism, or bone rheumatism.
  • Other serious illness, such as rheumatoid arthritis, cancer or leukaemia. The Beat Fatigue Workbook - how to identify the causes
  • There is also evidence that omega 3 helps people with inflammatory joint conditions such as rheumatoid arthritis. Times, Sunday Times
  • Rheumatic diseases such as rheumatoid arthritis, lupus, dermatomyositis, and scleroderma are thought to be autoimmune diseases.
  • One of patients is a young woman forced to endure the pain and misery of rheumatoid arthritis. Times, Sunday Times
  • Revenue from the rheumatoid arthritis and psoriasis drug Enbrel increased 3 percent to $939 million and sales of the hyperparathyroidism drug Sensipar grew 10 percent to $188 million. Amgen Buys Cancer Drug Maker
  • Now, new research suggests that a diet high in fruits and vegetables, including spinach, beans and pulses, olive oil and fish helps in the treatment of the joint condition rheumatoid arthritis too.
  • This may help ease pain suffered by people with inflammatory conditions such as rheumatoid arthritis. The Sun
  • A There are basically two kinds of arthritis - rheumatoid arthritis and osteoarthritis. Get the Best out of the Rest of Your Life
  • In rheumatoid arthritis the e. femoral nerve is often damaged a. principal lesion is an area of fibrinoid necrosis surrounded by fibroblasts 20. Recently Uploaded Slideshows
  • Our medications included everything from BP meds to the auto-immune suppressant and narcotic medications my husband needed to control rheumatoid arthritis. Other than your favorite foods, what was the hardest thing to give up when you moved to Mexico?
  • In overactivity or underactivity of those gene pro - rheumatoid arthritis, for example, the normal T - ducts in tumor cells). Recently Uploaded Slideshows
  • Those with rheumatoid arthritis often benefit from orthotic insoles. The Sun
  • We have implanted 76 biaxial total wrist prostheses as a primary procedure in patients with rheumatoid arthritis of the wrist.
  • A 2000 study published in the American Journal of Pathology demonstrated a single injection of the adjuvant squalene into rats triggered "chronic, immune-mediated joint-specific inflammation," also known as rheumatoid arthritis. [vii] Veterans Today - News for U.S. Military Veterans Jobs, VA Benefits, Home Loans, Hospitals & Administration
  • Perseid devleops drugs to treat autoimmune conditions like rheumatoid arthritis and transplant rejections. SWS Soars On Buyout, Maxygen Gets A Big Lift
  • Factors such as drinking three or more units of alcohol per day, a family history of osteoporosis and long-term rheumatoid arthritis are among those that can increase fracture risk. EurekAlert! - Breaking News
  • In conjunction with Kendall, Hench began to treat cases of chronic rheumatoid arthritis with cortin, but without success. Nobel Prize in Physiology or Medicine 1950 - Presentation Speech
  • It developed into rheumatoid arthritis, but being confined to a wheelchair didn't stop Jackie marrying and bringing up three children.
  • In the 1950s it was used in humans to treat rheumatoid arthritis and gout? Times, Sunday Times
  • Sjogren's syndrome can occur as a primary disorder or secondary to other autoimmune diseases, principally rheumatoid arthritis or systemic lupus erythematosus lupus, Belmont said. Why Sjogren's syndrome caused Williams to quit U.S. open
  • She had a restrictive defect later shown to be caused by a rheumatoid lung.
  • There is also evidence that omega 3 helps people with inflammatory joint conditions such as rheumatoid arthritis. Times, Sunday Times
  • Treatment and care for juvenile rheumatoid arthritis, other autoimmune disorders and pain amplification syndromes Rheumatology
  • A steroid, it's classed as an immunosuppressant, which is a good thing if you need it to suppress an autoimmune disease, such as lupus or rheumatoid arthritis, in which your body starts attacking its own tissues. Denver Post: News: Breaking: Local
  • Drinking a lot of tea may increase the risk of rheumatoid arthritis. Times, Sunday Times
  • A similar association that exists between psoriasis and cardiovascular disease is also found in cases of rheumatoid arthritis. Times, Sunday Times
  • Metallic gold rarely causes hypersensitivity, but organic gold compounds used to treat rheumatoid arthritis do.
  • Six were treated for rheumatoid, three for Crohn's disease, one for psoriatic arthritis, one for dermatomyositis and one for juvenile rheumatoid arthritis.
  • The only other large studies with controls examined hip fractures and rheumatoid arthritis and found odds ratios of 1.5 and 2.1.
  • He also suggests potential autoimmune tests such as the rheumatoid factor for rheumatoid arthritis, cryoglobulins for cryoglobulinemia as well as the erythrocyte sedimentation rate for evidence of general inflammation.
  • As the rheumatoid process progresses, inflammatory cells in the synovial fluid grow and form a mass known as pannus, which invades and destroys soft tissue, cartilage, and bone.
  • Rituximab is licensed to treat rheumatoid arthritis, but doctors also use it to treat vasculitis, which is a disease affecting the blood vessels. Epolitix News
  • Extremely high titers are associated with the presence of rheumatoid nodules.
  • In rheumatoid arthritis joints can fuse together and distorted build ups of calcium cause enlarged joints. The Family Nutrition Workbook
  • Type 1 diabetes, lupus, and rheumatoid arthritis are some examples of autoimmune disorders.
  • Applications: to chronic rheumatoid conditions and other inflammatory degenerative disease. The Dictionary of Modern Herbalism
  • The cervical spine in rheumatoid arthritis Needs careful assessment Rheumatoid arthritis commonly affects the cervical spine, causing several well defined deformities.
  • Being overweight or obese could protect men from rheumatoid arthritis, according to a study - but it does not help women. Times, Sunday Times
  • What to do: It's too early to conclude that decaf raises the risk of rheumatoid arthritis.
  • She has had rheumatoid arthritis for seven months and has difficulty walking and getting about.
  • Pulses of ultrasound are also sometimes used as a treatment for conditions such as rheumatoid arthritis and to heal fractures and wounds.
  • Rheumatoid arthritis is a multifactorial disease determined by both genetic and environmental factors
  • It is associated with autoimmune illnesses, including rheumatoid arthritis.
  • Rheumatoid arthritis is a painful, progressive condition that can be difficult to diagnose in the early stages because it often begins with only subtle symptoms, such as achy joints or early morning stiffness. Medlogs - Recent stories
  • This may happen due to injuries, infections, or even chronic problems like rheumatoid arthritis and leprosy.
  • HENSLEY: Osteoarthritis, primary dysmenorrhea, which is menstrual periods and rheumatoid arthritis, the pain associated with those conditions. Pfizer To Pay Record Penalty Over Promotions
  • TNF is a cytokine, or cell protein, that acts as an inflammatory agent in rheumatoid arthritis.
  • On October 17, 2009, Genentech and Biogen Idec announced that the companies received a complete response letter from the FDA for a supplemental Biologics License Application (sBLA) for RITUXAN plus MTX in patients with moderately-to-severely active rheumatoid arthritis (RA) who no longer respond to treatment with a disease modifying antirheumatic drug (DMARD), including MTX. THE MEDICAL NEWS
  • The worst thing about rheumatoid arthritis is that it is not as though you can just put your feet up, lie down and the pain will stop. Times, Sunday Times
  • The patient had rheumatoid arthritis, a condition associated with pyoderma gangrenosum.
  • This article outlines the surgical management of the most common painful conditions that affect the shoulder, including impingement, rotator cuff tear, frozen shoulder, osteoarthritis, rheumatoid arthritis and calcific tendonitis. Naturejobs - All Jobs
  • In fact, research points to benefits in the treatment of osteoarthritis, soft-tissue rheumatism, and rheumatoid arthritis.
  • If synovial fluid analysis fails to identify crystals, palindromic rheumatism should be considered; this condition may progress to rheumatoid arthritis.
  • Medications, hand splints and physical therapy can help in earlier stages of rheumatoid arthritis.
  • The only other large studies with controls examined hip fractures and rheumatoid arthritis and found odds ratios of 1.5 and 2.1.
  • Tests on 17 patients with rheumatoid arthritis showed it eased symptoms for those who failed to get better on powerful drugs. The Sun
  • However, her medical records indicate that she has bronchitis, TB, bilharzia, malaria, juvenile rheumatoid arthritis and multiple coughs and colds, all due to sickle cell.
  • The most common cause of iritis is juvenile rheumatoid arthritis.
  • Deformities of the cervical spine are seen most often in patients with rheumatoid arthritis of more than 10 years' duration.
  • For example, rheumatoid arthritis, systemic lupus erythematosus, and pemphigus occur more often in middle-aged people or sometimes in young adults.
  • Patients were included in the trial if they were taking oral steroids such as prednisolone for rheumatoid arthritis, lupus, asthma, or other chronic inflammatory disorders. MedPageToday.com - medical news plus CME for physicians
  • European approval of the drug — based on a decision by Dutch authorities — is for relieving symptoms of osteoarthritis, rheumatoid arthritis, and a type of arthritis of the spine called ankylosing spondylitis. EU Backs Astra's Arthritis Pill
  • This is probably what happens in rheumatoid arthritis, for instance. The Antioxidant Health Plan
  • Methotrexate is an antimetabolite that, apart from its use in malignant disorders, is taken orally in low doses for the control of conditions such as rheumatoid arthritis and psoriasis.
  • Metastatic lesions may be confused with a ganglion, epidermoid inclusion cyst, acute gout, and even rheumatoid arthritis.
  • More serious is rheumatoid arthritis, where antibodies to antibodies are produced. The Family Nutrition Workbook

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