How To Use Profound In A Sentence

As a consequence of the profound decrease in T2 B cell numbers, their downstream mature B cell progeny, namely follicular and marginal zone B cells, were drastically depleted. PLoS ONE Alerts: New Articles
Sons don’t resemble their fathers in every detail, I’ve noticed it time and time again, and there’s many a woman brought to bed of a son who is profoundly thankful for that fact, and expends a great deal of her postpartum energy assuring the sprog’s tata that the sprog is a dead ringer for her great-uncle Lucius Tiddlypuss. The First Man in Rome
Not for a very long time has the discovery of new music so profoundly moved and excited me as the contents of this disc.
Modern scientific capability has profoundly altered the course of human life. Times, Sunday Times
The art world can be a profoundly unfriendly and unbalanced place. Times, Sunday Times

Note also the profound hypochondriasis and fear that they are being infected by a "cancer"--again, a plot presumably put together by the Jews. Archive 2009-02-01
I see his sensibility as basically that of an earlier age: he is a chivalric knight devoted to his lady; this devotion is like that of a medieval Christian who lives in the world yet profoundly venerates the Virgin Mary. Sena Jeter Naslund - An interview with author
Reading makes a full amn, meditation a profound man, discourse a clear man.
Profound stupor associated with depression also responds to IV sodium amobarbital, thus permitting conversation between the patient and examiner, which often reveals depressive symptoms. The Neuropsychiatric Guide to Modern Everyday Psychiatry
Profoundly discouraged, we ride on after this in mournful silence. Untrodden Peaks and Unfrequented Valleys
But at the core of it all is a profound curiosity about the thinking process.
They are sharing, in a companionable silence somehow caught on camera, a moment of profound reflection and thought.
The inconsistency and its effects were so profound as to render such guidance invalid. Times, Sunday Times
These projects are extremely important, and they raise profound questions regarding appropriate intellectual property policies.
Against any tendency to naturalize evil, Julian sees evil as profoundly unnatural, unkind.
It should be clear by now that Jackson has been royally twisted by the trifecta of supernova fame, seemingly unlimited cash, and a profound loneliness - none of which he asked for.
It is a narrative of profound depth and originality. Times, Sunday Times
It has profoundly negative connotations. Times, Sunday Times
There are some fairly profound ideological disagreements within the movement.
Behind the apparent cross-party consensus on social mobility lie two profound philosophical differences. Times, Sunday Times
This common-sense approach to philosophy had a profound impact on early American history. Christianity Today
He bought his records on import, and the exclusivity and rareness of the music gave it a profound glamour.
So, much as I’m weary of western politicians who couldn’t tell the Ka’ba from a peach cobbler going on about how extremists are “perverting” Islam — how the hell do they know? — this article, which got its author suspended from his radio talk show hosting job for its claim that “Islam is a terror organization,” is truly, profoundly stupid. Excommunicated from the Ummah?
I love contemplative first person narratives, in which nothing happens and yet everything of significance is profoundly altered. Molly Fox’s Birthday « Tales from the Reading Room
Kindness in words creates confidence. Kindness in thinking creates profoundness. Kindness in giving creates love. Lao Tzu
For in opening their lives to the entire expanse of Greco-Arabic and Hebrew learning, the dictionally pure Jewish poets of Cordoba, Granada, and Saragossa carried out an act of profound, if paradoxical, cultural redemption. The Lost Jewish Culture
In March 1525, the king recalled Charles Brandon, Duke of Suffolk, from his role as justiciar of North Wales and, in south Wales, the long-time crown agent, Sir Rhys ap Thomas, had died in the spring. 66 This household was to have a profound effect on Mary's political status and composition of future households. 67 From Heads of Household to Heads of State: The Preaccession Households of Mary and Elizabeth Tudor, 1516-1558
Listening to the orchestra perform these profound works in the Ulster Hall demonstrated once again what fine acoustical properties the hall has.
And Moore, perhaps more than a little challenged by his own insecurities, has made a film that is profoundly invested in manhood, masculinity, machismo.
Still more profound a touch is that where Ottima, daring her lover to the "one thing that must be done; you know what thing: Come in and help to carry," says, with affected lightsomeness, "This dusty pane might serve for looking-glass," and simultaneously exclaims, as she throws them rejectingly from her nervous fingers, "Three, four -- four grey hairs!" then with an almost sublime coquetry of horror turns abruptly to Sebald, saying with a voice striving vainly to be blithe -- Life of Robert Browning
But it has mainly been studied in particular patients with profound impairments of memory, despite otherwise normal cognitive ability and intelligence.
There are few stamps of authenticity more profound than the voice of the subject. Times, Sunday Times
Macha is 145 pounds of phlegmatic composure, a St. Bernard who can't help but look dignified and profound, even when she is waiting for a treat.
Rapid production of such large amounts of material clearly has profound effects on the land round the volcano.
Society has changed so profoundly over the last fifty years.
Apologists wishing to exploit a revisionist history of science invariably stress the profoundly religious orientation of many prominent scientists.
The spread of print, the rise of mass literacy, and print's visual nature caused a profound change in the cognition of individuals from an auditory, holistic, collective functioning towards a visual, private outlook (and inlook) of the exterior and interior worlds. Citizendium, the Citizens' Compendium - Recent changes [en]
I refer to the far greater and more sweeping drama in which we are all caught up and which will profoundly affect our world view in the years ahead.
The first couple he tried were both profoundly deaf, and he didn't get much reaction beyond a bewildered smile.
The first common theme is a profound sense of entrepreneurship. Times, Sunday Times
It is your special responsibility, dear monks, to be living examples of this interior and profound relationship with him, implementing without compromise the program that your founder summarized in the "nihil amori Christi praeponere" [put nothing before the love of Christ.] (Rule 4.21). More from Montecassino
Researchers have produced human embryos containing DNA from three people, a biotechnological proof-of-principle with profound medical and ethical implications. 3-Parent Embryo | Impact Lab
This has profound implications for our relationship, which should mirror that of Gods; caring and nurturing love for us.
Witnessing the devastation and tragic scenes of human suffering left an indelible impression on Burchett and had a profound effect on the rest of his life.
Hikari, the idiot savant, under various names is, in Oe's hands, an effective and necessary literary device; no single version could encompass his profound meditation on his son's – and the human – condition. Kenzaburo Oe: Laughing Prophet and Soulful Healer
In recent years, the country has suffered a profound political and economic crisis, and depravation is acute.
The degree of serenity that she brought to a day fraught with nerves made a profound impact. Times, Sunday Times
It is hard to convey quite how profoundly last Tuesday's attack will change the character of New York, but there is a sense of unutterable loss, which the city is still struggling to make sense of.
On narrative discourse, the existing classification dig out the profound implication imbedded in every genre.
The eyes of those suffering from brain damage showed a most profound distress.
He had pointed this out to her quite a while ago, marveling over the symbolism and profoundness of such a matching.
Drawing on a number of empirical research programs, Shapiro cites examples that appear to support what he calls the embodied mind thesis, viz., that “minds profoundly reflect the bodies in which they are contained” (Shapiro 2004, p. 167). Concepts
There were profound political issues that underlay our choices about what we sang, and what we did and why we did it.
The issues surrounding genetic engineering of this sort are even more profound.
Love is that condition in the human spirit so profound that it empowers us to develop courage; to trust that courage and build bridges with it;to trust those bridges and cross over them so we can attempt to reach each other. Maya Angelou
The flight from that reality strikes me as a more profound pathology than the reality itself.
The destruction of Washington had been a profound shock. The American Nation: A History of the United States to 1877
Last, in 1896 in Plessy v. Ferguson, another profoundly antilibertarian decision, the Supreme Court held over the lonely dissent of John Marshall Harlan, that the broad police power of southern states could allow them to force segregation in public transportation and public schools, and impose antimiscegenation laws. Rand Paul's Wrong Answer
The back is usually more profoundly black, and the muzzle, ears, and limbs have cinnamon coloration as well.
The recent riots across Britain, whose origins many believe lie in an absence of either parental guidance or filial respect, seem to underline a profound difference between East and West.
He grew up in profoundly rural America and was graduating from flight school about the time of Pearl Harbor. Matthew Yglesias » Age and the War
Sustainable dynasties rely on something more profound. Times, Sunday Times
RH Tawney.had the measure of this kind of bobbins about 80 years ago: "While natural endowments differ profoundly, it is the mark of a civilised society to aim at eliminating such inequalities as have their source, not in individual differences, but in its own organisation. The Guardian World News
As a psychological phenomenon, physiognomic perception has profound effects upon words' evolvement including coinage, word formation, and change of word meaning.
Sabriel felt a strong undercurrent of understanding pass between them, and received the profound impression that she had made a loyal friend for life.
I like to think my syndactyly is an outward indication of some other greater, more profound mutation. Syndactyly (Webbed Toes/Fingers) Forums
Other freshman classes have exerted a much more profound immediate influence, though in fairness some of the guys this year were shackled by the presence of more experienced players ahead of them who would have been difficult to unseat from the lineup. Top newcomer? John Wall runs away from a talented field
Lord Ogleby calls him his "cephalic snuff, and no bad medicine against megrims, vertigoes, and profound thinkings. Character Sketches of Romance, Fiction and the Drama, Vol. 1 A Revised American Edition of the Reader's Handbook
The profound neglect of psychological, social and political considerations renders such treatments shallow and incomplete.
Many more are still alive, but profoundly vulnerable.
This period has witnessed major changes in our diets, lifestyle, and social practices, some of which may be having profound effects on human health.
The hard helotism to which the tremendous range of the sciences condemns every scholar today is a main reason why those with a fuller, richer, profounder disposition no longer find a congenial education and congenial educators.
However profoundly the Honourable Member for Eatanswill might resent it, the issue of expenses and allowances for MPs and Peers is not going to go away. Archive 2008-01-20
The urbanization of the mass of the population and the decline of rural areas not surprisingly had profound social consequences for all classes of the population.
My father's death had a profound effect on us all.
Discussing and expounding this problem has not only profound academic significance, but also positive practical significance.
During this period of social assistance to the later made a profound insight.
It is a compelling tool that profoundly amplifies the book's effect. The Times Literary Supplement
It is also clear that the rural areas have seen a profound decrease in the availability of agricultural employment. Migrants in Modern France: Population Mobility in the Later Nineteenth and Twentieth Centuries
It had quite a profound effect on me, giving me a real thirst for beauty and culture. Times, Sunday Times
It's the profound whimsicality that troubles me. Times, Sunday Times
Discover the hidden lesson in each experience to develop a profound understanding of life and yourself.
To write stories of profound public interest about abuse of power in public office. The Sun
Life is a profound book.Other's notes cannot replace your own understanding.May you find and create something new in it.
There was something both wicked and profound in his smile. The Broken God
I give you my profound thanks for saving my life.
Trinity, we understand that true openness does not mean loss of individual identity but profound interpenetration. New Releases
Profound depression and vegetative symptoms result from realizing nothing that individuals do matters and that there is no way to end, foreshorten or even know the duration of their suffering. OpEdNews - Diary: Letter to Senate on health effects of indefinite detention
In reality, Sullivan's decision to sign Elvis augured a profound change in American taste. John W. Whitehead: Elvis Presley: Down Lonely Street at the Heartbreak Hotel
The fact that no one has claimed responsibility only underscores the profoundly reactionary character of these attacks.
Voicing various concerns, including claims that Capital was "overpaying" for the shopping centre and transferring control to Peel "while failing to extract a premium for it", the US group's chief executive, David Simon, said the company was "disappointed by the profound value destruction proposed to be inflicted on CSC and its shareholders". The Independent - Frontpage RSS Feed
In other words the Greek seems to encompass a profound complexity of meaning as regards the placement (if that is the right word) of the head cloth, napkin, or, in fact, the σουδαριον/sudarium (in essence the same word, evidently a technical term in the repertoire of near eastern undertakers in Roman-occupied Palestine). Archive 2009-04-01
He is profoundly deaf and uses hearing aids until he can have a cochlea implant later this year.
It just had a profound effect on my life. Times, Sunday Times
Muscular dystrophies are genetic disorders, usually progressive, which can lead to profound paralysis.
The generous outreach to Sunnis is widely viewed as a profound betrayal by Bahrain's rulers and feeds Shiite perceptions of second-class status and being under siege from what they call a "mercenary" security force. The Seattle Times
Severe toxicity leads to coma, profound hypotension, bradycardia, and asystolic arrest.
For both of them it was a moment of profound shock. Times, Sunday Times
But is there something more profound going on with the weather? Times, Sunday Times
His entire approach to the Art of Following was underpinned by a profound sense of ceremony. BEHINDLINGS
There are illegitimate children over the years, accusations of collusion with Nazis, shadowy tales of unrequited longing and profound unfairness.
-- In this solemn and impressive prayer, in which they make public confession of their sins, and deprecate the judgments due to the transgressions of their fathers, they begin with a profound adoration of God, whose supreme majesty and omnipotence is acknowledged in the creation, preservation, and government of all. Commentary Critical and Explanatory on the Whole Bible
Tarkovsky's spirituality is profoundly alien to the west's dualism: it is earthly, earthy, as cool and clear and material as the water his camera spends so long dwelling upon.
Film biography, a special film of genre with a long historic tradition, profound aesthetic particularity and stong vitality during the whole development of cinematics.
All the profoundest certainties of being were forfeit in the face of it. THE GREAT AND SECRET SHOW
The truth is that much of Israeli public opinion is profoundly confused at moment.
Clearly inflected by the more profound nuances of Japanese tradition, Pawson's spirit of sensuous rationalism meets such pragmatic challenges head on.
All at once he fell into a state of profound melancholy.
Such immersion in the language and ways of the Andalusian countryside profoundly influenced his sensibility.
It is the profound, incurable, and inextirpable bigotry of the English people, to which they will not hesitate to sacrifice the national honour, the public happiness, their own liberties, and their own consciences ... .... Travels in the Great Desert of Sahara, in the Years of 1845 and 1846
Her rape had a profound psychological effect on her.
It was widely acclaimed and it profoundly boosted the study of ancient life.
Zang Kejia left a rich legacy to contemporary Chinese Parnassus after he passed away. His new poetry creation still has profound influence on modern poets.
The average girl has little love of sozzling and mussing with the elements, and cooking involves problems in organic chemistry too complex to be understood very profoundly, but the rudiments of household chemistry should be taught. Youth: Its Education, Regimen, and Hygiene
Garbarino's caring is leaving Gilchrist with a more fitting, profound legacy while Garbarino's interaction with the old gridder helped fill a void left by leaving police work. NYDN Rss
The whole emphasis is placed on the terms being negated, thereby reflecting a profound bias towards aggression as the norm.
Body black, with large, dense, not very profound punctures; elytra with the punctures towards the suture longitudinally confluent; a sub - lunate or triangular, dull rufous spot rather behind the middle of each elytrum; tergum with the punctures not smaller at the posterior mar - gins of the segments; feet dirty yellowish; thighs blackish above — Transactions of the American Philosophical Society
She had profound and multiple learning difficulties and complex health needs as a result of a spinal condition. Times, Sunday Times
At a greater distance from the throne are the inferior nobles, also standing in the same posture of profound reverence.
Hurrying out with a profound sense of failure, she brushed by a man watching from the stairs of the rehearsal studio.
Some of the company, however, regard this as too profound, and after trying their skill at the cottabus betake themselves to the never failing chances of dice. A Day in Old Athens; a Picture of Athenian Life
This has a profound effect on attention spans. The Sun
I've always firmly believed that America is the profound, pure-hearted and unhesitating companion to us France, Europe and the international peaceful environment.
Instead, it will be a vehicle for gradual, quiet yet profound social change.
Yet the burden of geography has not changed, while the Russian state has changed profoundly since the ascension of Putin.
He claims that it is the most profound change in secondary school teaching in 25 years. Times, Sunday Times
He sighed with profound resignation.
Songs of profound depth were tinged with an irrepressible air of mischief. Times, Sunday Times
Her speech made a profound impact on everyone.
Sad and profound chants are intoned in the wind and I am in the presence of a numberless and devout congregation.
Her speech made a profound impact on everyone.
Life is a profound book.Other's notes cannot replace your own understanding.May you find and create something new in it.
Not only does a journal provide a storehouse of material, and encourage sharp observation and profound reflection, but also it is developing the habit and skills of writing through regular engagement.
After having put in practice all chivalries, devout and worldly, gone with Peredur in quest of the Holy Grail and fair ladies, and dreamed with St. Brandan of mystical Atlantides, who knows what it would produce in the domain of intellect, if it hardened itself to an entrance into the world, and subjected its rich and profound nature to the conditions of modern thought? The Poetry of the Celtic Races. VI.
One of the most profoundly beautiful reggae songs ever made, Fisherman bathes the daily grind in a spiritual light, naming its titular anglers after four of the disciples (dubbed Fishers of Men by Jesus), though it's not known whether the original apostles also stopped off to see the local collie man. Expecting Rain
Each has had a profound effect on the area and more widely. Times, Sunday Times
Clearly, these celebs were making a statement - probably at the direction of their handlers - seeking to be as profound as Madonna and Britney were.
Profound desire, true desire is the desire to be close to someone. Paulo Coelho
The political effects of transforming a large part of British society from homeowners back into renters could be profound. Times, Sunday Times
It was just an ongoing horror through profoundly depressed landscape.
Life is a profound book.Other's notes cannot replace your own understanding.May you find and create something new in it.
I am profoundly grateful to you all.
The seats in each row are only about four centimeters higher than the seats in front of them, so that my experience of M. Ward's performance is profoundly hampered by the wispy, frizzled locks of the enormous, grotesque head in front of me.
That feeling of control I mentioned is even more profound when I know I can take my script and move it to another type of operating system later and it will behave the same way.
Since losing his job, he has often experienced a profound sense of ennui.
The deformity may be so severe, the fractures so numerous, and the disability so profound, however, that almost any form of treatment deserves consideration.
Groucho Marx's flippant remark about the inability of any photograph to capture his inner beauty is profoundly insightful.
Localized wage bargaining was symbolic of the decentralization of decision-making in general, a process involving a profound change in managerial culture.
But the political ramifications could be equally profound. Times, Sunday Times
Edwin, sunk in weariness, said little in opposition; and having suffered Monteith to take away his sword and to unbrace his plated vest, dropped at once on the straw in a profound sleep. The Scottish Chiefs
This has not removed the scope for profound disagreement about the relevance of such conditions.
Dr David Hope praised the Queen's ‘unstinting service, profound wisdom and unswerving faith’ during her 50-year reign at a special festal evensong at York Minster.
As a result, what we see is consistently open to interpretation, often with profound and tragic consequences.
Tree rings from 678 Great Basin bristlecone pines taken from the White Mountains, and Mount Washington and Pearl Peak, NV have shown scientists that rising temperatures are having a profound impact on the slowest growing, ancient pines on the planet. Dr. Reese Halter: Saving the Ancient Pines by Reducing our Global Footprints
But the most profound voice in popular music today inveighing against spiritual alienation and emotional disconnectedness comes from New Jersey.
In listening to these works with their clumsy blocks of tone, their eternal sunless complaining, their lack of humor where they would be humorous, their lack of passion where they would be profound, their sardonic and monotonous bourdon, one is perforce reminded of the photograph of Reger which his publishers place on the cover of their catalogue of his works, the photograph that shows something that is like a swollen, myopic beetle with thick lips and sullen expression crouching on an organ-bench. Musical Portraits Interpretations of Twenty Modern Composers
So it does have a profound effect. Times, Sunday Times
Beginning in Early Miocene time, southward extrusion of the Greater Himalayan Slab has had a profound influence on the geological and geomorphological evolution of the Himalaya.
When by our continued posture in sleep, some uneasy sensations are produced, we either gradually awake by the exertion of volition, or the muscles connected by habit with such sensations alter the position of the body; but where the sleep is uncommonly profound, and those uneasy sensations great, the disease called the incubus, or nightmare, is produced. Zoonomia, Vol. I Or, the Laws of Organic Life
The sheer range and interconnectedness of the problems that the nation faces are such that any permanent solution to any one of them will require profound systemic change that will necessarily upset many economic, political and cultural equilibria. Ron Paul Can Win
From a windle the thread is conducted to the quills, and buzz, buzz goes Margaret's wheel, while a gray squirrel, squatted on her shoulder, inspects the operation with profound gravity. Margaret
In him in that broad and profound ideology, economic thought has all in all position.
Life is a profound book.Other's notes cannot replace your own understanding.May you find and create something new in it.
What had begun as a schoolgirl crush had grown into a profound and romantic desire to be Charles's bride.
His voice was low but what he said was profound. Times, Sunday Times
Among their findings, mice heterozygous for a null mutation of the alpha-isoform of calcium / calmodulin-dependent protein kinase II show profoundly dysregulated behaviors, including a severe working memory deficit and an exaggerated infradian rhythm (cycle of increases and decreases in locomotor activity in their home cage; 2-3 weeks / cycle), which are comparable to the symptoms observed in patients with schizophrenia, bipolar disorder and other psychiatric disorders. Dailyindia.com News Feed
In him in that broad and profound ideology, economic thought has all in all position.
‘I realised immediately that this was going to be a profound anecdote, and I've been dining out on it since,’ he purrs, with typical blitheness.
This election has profound implications for the future of U.S. democracy.
While I do think the saints have spiritual maturity, often very saintly people and profoundly religious people struggle with other personality conflicts.
The financial effects of disability can be profound, because living expenses continue to accrue and may actually increase during the convalescent period.
A more profound regret is his continuing absence from the best rides at the big meetings. Times, Sunday Times
Romans of every political stripe were profoundly upset by the events of Tiberius’ tribunate.
The inconsistency and its effects were so profound as to render such guidance invalid. Times, Sunday Times
Reading makes a full amn, meditation a profound man, discourse a clear man.
The discovery has profound implications for astrobiology.
There are three very simple but profound advantages to a more casual style of dressing.
This has made a profound influence upon the current leadership education.
Dissidents are suppressed in profoundly unfair ways in every country on earth. Matthew Yglesias » Means and Ends
The most noticeable rhetorical development in this sequence is the profound infantilization of Stephen's represented speech and the repeated ascription of shyness, timidity, and silence to Stephen and his soul.
The regime is profoundly divided against itself.
DadBoner, who is either a real person or a profound literary construction, the despondent American post-marriage male persona nonpareil, Homer Simpson's Kafkaesque better. Aaron Belz: Literary Twitter: @DadBoner
a remarkable coexistence of two profoundly different artistic traditions
More often, of course, separation involves a younger carer giving up the role, about which there is often profound ambivalence.
It had some sort of profound effect upon me as later that afternoon I had a wash, including my hair, and changed my underwear.
The world today is undergoing a transformation as profound as the industrial revolution. Sociology
The term “sensation novels” emerges as a profoundly apt encapsulation of the qualities of strangeness this process of abjection is locked onto (and one that is a precursor of “genre fiction” and comparable with “coloured people” in its disregard for the sensationalist content of writers like Charles Dickens, Thomas Hardy, Emily Brontë and countless others in the canon). What is Literary Fiction?
He's a modern artist of the old school: utterly fearless, profoundly confusing and completely bonkers.
Sport is frequently spectacular and often dramatic, but it has more profound possibilities as well. Times, Sunday Times
But why then did not those profound rabbies amongst the Jews, and the Stoicks and Epicureans (those oracles of reason) amongst the philosophers, baffle and refel these babblers, and so dashing their absurd doctrine in its first rise, prevent its spreading, by a mature and thorough confutation? Sermons Preached Upon Several Occasions. Vol. IV.
The tricksy plots of Babel and 21 Grams felt more O. Henry than oh so profound to me. Michael Giltz: Cannes 2010 Day Six and Seven: Biutiful is Beautiful and Jia is Beautifuler
Naturally, we hope every citizen will vote, a simple obligation of democracy with results that profoundly affect our lives.
Two profound changes in our society have enabled small companies such as us to survive: the Internet and parcel delivery systems.
Straight back to her dinner of ham and pickled beets, then an immediate swoon of profound, dreamless sleep. THE LAST REPORT ON THE MIRACLES AT LITTLE NO HORSE: A NOVEL
I wonder, has this censor never found in poetry a vision of truth more profound than can be told in syllogisms?
Localized wage bargaining was symbolic of the decentralization of decision-making in general, a process involving a profound change in managerial culture.
To these vitally important and profound questions there are no simple answers.
Perhaps it was as well that continental drift was so profoundly unfashionable in the 1920s and 1930s. THE EARTH: An Intimate History
But something else, something quite profound, also arises out of this musical-chair play-acting: the sense that bodies are receptacles for all manner of life forces to pass through.
However, this software already has had a profound effect on the personal computing industry.

How To Use Profound In A Sentence

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