How To Use Platelet In A Sentence
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It said Plavix "has met the long-felt need for an effective and safe antiplatelet drug," as evidenced by clinical trials proving its safety and effectiveness versus aspirin.
Sanofi, Bristol Reap Two Victories on Plavix
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Apyrase, an enzyme in tick saliva, may maintain blood flow into the bite by stimulating local vasodilation and preventing platelet aggregation.
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These results suggest the involvement of platelet activating factor in the endothelin induced fibrinolytic activation and subsequently developed mucosal haemorrhagic lesion.
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They found a peptide in urine from autistics that increased platelet content of serotonin, which is also a common finding in autism.
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For example, a person can receive only platelets, red blood cells, or a clotting factor.
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Aspirin prevents heart disease by keeping the platelets in our blood from sticking together and forming a clot.
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The significance of platelet activating factor in the gastric juice of healthy humans is still difficult to analyse.
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Thus diminution of prostacyclin production and stimulation of platelet aggregation both mediated by lipid peroxides could contribute to thrombosis on atheromatous plaques.
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Canadian Blood Services' plasma donors may undergo apheresis up to 52 times a year while platelet donors may donate 26 times a year.
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The medical college should be provided facilities to separate all blood components such as leukocyte depleted blood, cryoprecipitate and platelet concentrate that is necessary for the treatment of blood-related diseases.
The Hindu - Front Page
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Platelet binding falls after the menopause and rises in women using the Pill.
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Platelet activating factor may be involved in the pathogenesis of ulcerative colitis as well as in experimental colitis.
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The patient subsequently received platelet and red blood cell transfusions.
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Symptoms of the severe stage include oliguria (decreased urine output), hypoxemia (low partial pressure of oxygen in the blood), low platelet count, trouble breathing, areas of mottled skin or a sudden change in mental state or condition.
EHow - Health How To's
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Although platelet thromboxane generation was elevated in diabetics without clinical evidence of vascular disease, the difference did not reach statistical significance.
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The donor bag was then centrifuged and the platelet-rich plasma transferred to a sterile plastic centrifuge bottle.
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Platelet aggregation tracings of the PRP from 12 healthy individuals, adjusted to five different plasma fibrinogen concentrations, were the primary parameter measured.
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As knowledge of basic platelet metabolism increases it will be more easy to identify platelet abnormalities and their pathogenesis in diabetes mellitus.
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Additionally, he is the Director of the Northern Blood Research Centre, supervising research in platelet function, hypercoagulability in cancer and other disease states, and global tests of coagulation.
Instrumentation Laboratory to Host 2nd Asia Pacific Hemostasis Forum -- BEDFORD, Mass., Sept. 23 /PRNewswire/ --
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Lyso platelet activating factor and alkyl acyl glycerophosphocholine were not significantly higher in Crohn's disease than in controls.
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Purpura may be secondary to thrombocytopenia, platelet dysfunction, coagulation factor deficiency or vascular defect.
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Objective To assess the influence of apheresis and wash on platelet function and morphology. Washed platelet of quality and clinical effect were observed.
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They can help your body to make healthy red and white blood cells or platelets.
The Sun
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Splenomegaly or giant hemangioma can result in thrombocytopenia because of platelet sequestration.
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The benefits of antiplatelet therapy outweigh any hazards.
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The platelet and leukocyte analysis showed he had cancer no more.
GRACE
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Previous transfusions may sensitize patients to foreign platelet antigens.
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The Separation efficiency of red blood cell, white corpuscle and blood platelet from pig blood was investigated by chromatographic columns of four celluloses and two ion-exchange resins.
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Objective To investigate the Clinical significance and the changes of serum parathormone (PTH) in the platelet donors with long-term donation.
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Objective To investigate the platelet inhibition ratio by thromboelastography (TEG) and its clinical impact in patients undergoing percutaneous coronary intervention (PCI).
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The content of platelet activating factor in pancreatic tissue was determined using bioassay technique with washed rabbit platelets as described previously.
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The level of platelet activating factor in the rat gastric mucosa was determined after the administration of endothelin-1 using a radioimmunoassay method.
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See also q arm. pharyngeal transfer: phase in which food is moved past the airway to the esophagus. pharynx: the throat. phenotype: the visible expression of a gene. platelet: blood cell which assists in blood clotting — also called a thrombocyte. pneumonia: lung inflammation as a result of infection.
Glossary
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And reports that his platelet count is low, when considered with this picture in which he looks jaundiced, his face emaciated, but his belly bulging - all suggest liver failure.
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Objective To study the relationship between microangiopathy and activated platelet in patients with - insulin - dependent diabetes mellitus ( NIDDM ) .
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The most serious side effects include gastrointestinal bleeding and perforation, renal dysfunction, and platelet dysfunction.
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Quebec platelet disorder is an autosomal dominant bleeding condition associated with a gain-of-function defect in fibrinolysis resulting from a 78 kb tandem duplication on chromosome 10q24 that includes
MedPageToday.com - medical news plus CME for physicians
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Actin and other contractile proteins within the pseudopods of platelets produce platelet retraction that prevents further blood loss and facilitates healing.
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This rapid platelet decrease suggests an anamnestic response (i.e. a rapid immune response to new antigens by an already primed immune system).
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The researchers wanted to evaluate clopidogrel as a potential treatment for dogs with hypercoagulability due to excessive platelet activation.
EurekAlert! - Breaking News
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Canadian Blood Services' plasma donors may undergo apheresis up to 52 times a year while platelet donors may donate 26 times a year.
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Maternity blues linked to platelet receptors TWO-THIRDS of women suffer from postnatal depression, accompanied by crying, confusion and tension.
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Scientists have known that a protein called thrombin plays an important role in clot formation as a potent activator of platelets.
Undefined
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Another hypothesis suggests that the defect is extensive arteriolar endothelial damage which leads to subsequent platelet activation, adherence, occlusion, and fibrin strand formation ultimately producing thrombocytopenia and microangiopathic hemolysis.
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Patients receiving chemotherapy, along with IP6 + Inositol did not have cytopenia, drop in leukocyte and platelet counts.
BioMed Central - Latest articles
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The temperature of platelet intracellular ice crystal formation (IIF) is one of the most important physical parameters to instruct platelet cryopreservation.
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In contrast, the flexible protein structures in a bobtail squid's platelets can quickly change configuration.
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Both cell types generated platelet activating factor activity and this was generally comparable for epithelial and lamina propria cells.
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Although platelet thromboxane generation was elevated in diabetics without clinical evidence of vascular disease, the difference did not reach statistical significance.
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To determine that the detected metabolite was due to modification of quercetin by platelets, untreated platelets (4A inset: plasma control) and quercetin aglycone (4D. ii inset) were examined to confirm the absence of tamarixetin.
PLoS ONE Alerts: New Articles
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It can unusually taller the plants that have quinine of platelets, which are hypoglycemic for spasmolytic caryophyllene clotting.
Wii-volution
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About 24 hours before assay the sample was placed in 80% ethanol to extract platelet activating factor from the tissue.
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‘It reduces the stickiness of platelets and makes the blood less able to clot, which is the cause of strokes,’ she said.
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Aggregating activity of the samples was measured over the linear portion of the calibration curve obtained with synthetic platelet activating factor.
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Aspirin reduces the risk of heart attack by reducing platelets' ability to clump together.
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The Separation efficiency of red blood cell, white corpuscle and blood platelet from pig blood was investigated by chromatographic columns of four celluloses and two ion-exchange resins.
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Platelet-derived growth factor is a major polypeptide growth factor found in human serum, platelets and fibroblasts and is a potent mitogen for cells of mesenchymal origin.
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Now, Becky donates just platelets and plasma via a process called apheresis.
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These results suggest the involvement of platelet activating factor in the endothelin induced fibrinolytic activation and subsequently developed mucosal haemorrhagic lesion.
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Platelets collected by apheresis were counted as single units.
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Murphy MF, Waters AH . Immunological aspacts of platelet transfu sions. British Journal of Haematology 1985, 60:409.
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Aspirin suppresses prostaglandin (which inhibits platelet activation and dilates blood vessels) and thromboxane (which encourages platelet activation and constricts vessels).
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Some hematology instrumentation prints the red cell and platelet histograms as part of the report.
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Upon admission, he was immediately given a transfusion, and has since had 6-8 "platelet packs," which consist of platelets that have been centrifuged out of whole blood.
It's Always about the Blood
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Platelet membranes bear a higher density of receptors per surface area than any other blood cell.
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Although the results are based on the number of red cells received, we estimated that patients would also have received fresh frozen plasma from 1630 donors, platelets from 3819 donors, and cryoprecipitate from 279 donors.
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One of them, apyrase, cuts apart the glue made by the platelets; other chemicals widen blood vessels to bring in more blood.
Parasite Rex
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Occasionally, a substantially increased platelet or white cell count may lead to apparent increases in plasma potassium concentration.
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Platelet concentrates also have the potential to improve fracture healing and enhance osteogenesis.
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For legitimate emergencies, the body also keeps on hand a supply of platelets.
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Patients with coronary artery disease undergoing angioplasty should continue taking antiplatelet drugs as usual.
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They then tested the functionality of the cultured platelets by infusing them into immunodeficient mouse models and confirmed that they had the same life span as human platelets infused in mice.
Reuters: Press Release
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JONATHAN GLASHOW, ORTHOPEDIC SURGEON: Platelet-rich plasma or sometimes called autologous condition plasma which means taking your own blood and taking a fraction of that blood and putting it in the area where it's most needed.
CNN Transcript Dec 15, 2009
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Thrombolytics The treatment of thrombolytic associated ICH is empiric and includes infusion of six to eight units of platelets and ten units of cryoprecipitate [1,106].
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Further, the PROTEX Stent System may eliminate the need for long-term antiplatelet therapy, thereby decreasing costs and reducing bleeding risks to the patient.
Health News from Medical News Today
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A lifelong bleeding diathesis may suggest a congenital platelet dysfunction, but an onset in adulthood does not necessarily exclude a congenital problem.
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Ticagrelor (BRILINTA (TM)) is an investigational oral antiplatelet treatment for ACS and the first in a new chemical class, the CPTPs (cyclo-pentyl-triazolo-pyrimidines).
Health News from Medical News Today
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Occasionally, a substantially increased platelet or white cell count may lead to apparent increases in plasma potassium concentration.
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Platelets are quite sensitive to outside signals because they have to clump together to prevent blood loss.
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The significance of platelet activating factor in the gastric juice of healthy humans is still difficult to analyse.
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This platelet release reaction and aggregation lead to the recruitment of many other platelets to the vessel wall with the formation of a hemostatic platelet plug.
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Platelet-adhesion studies Early studies of platelet function in diabetes used in vitro tests of platelet adhesion.
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The sulfide metabolite of sulfinpyrazone affects platelet aggregation by inhibiting thromboxane production.
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A positive correlation was found between glycosylated haemoglobin concentration and the prostacyclin concentration necessary to inhibit ADP-induced platelet aggregation by 50 percent.
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Platelets are blood components that aid clotting.
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The pharma group's sales in the region in 2009 were driven by products such as the Yaz oral contraceptive pill, Nexovar oral anti-cancer medication and the antiplatelet AspirinCardio.
Bayer Schering Pharma to Invest Heavily in Asia
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The products included all categories of red blood cells, platelets, and plasma (including cryoprecipitate), as well as autologous whole blood transfused into adult patients.
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How platelets help cancer invade other tissues Category: Cancer / Oncology News
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It appears that both the antiplatelet aggregation activity as well as the analgesic action of aspirin 22 potentiates the effect of pentoxifylline.
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The level of platelet activating factor in the rat gastric mucosa was determined after the administration of endothelin-1 using a radioimmunoassay method.
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The possibility that intestinal epithelial cells may produce platelet activating factor has been suggested by Kald etal.
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Although Alex is currently in remission, which means that his leukemia cells have been adequately reduced to allow for the return of healthy red and white blood cells and platelets, his journey is not over.
Leukemia Story: Alex
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However, it may be a sign of platelet or vascular disorders and is common in leukaemia and HIV infection.
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Maternity blues linked to platelet receptors TWO-THIRDS of women suffer from postnatal depression, accompanied by crying, confusion and tension.
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The main secondary outcomes were recorded treatment with hypotensive agents, lipid lowering drugs, and antiplatelet drugs.
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Inhibition of platelet adhesion and aggregation, prolonged bleeding time, purpura, postoperative wound hemorrhage
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This suggests that platelets must possess very sophisticated intracellular control mechanisms.
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Lack of platelets prevents blood clotting and leads to haemorrhage, both internally in the intestines and externally on the lips and gums.
GRACE
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Platelets are studied in an artificial environment and the very process of preparing the platelet sample for study may affect their behaviour.
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This literature mainly comprises the variation in genes for blood coagulation factors, inhibitors, fibrinolytic factors and platelet membrane receptors.
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Mikos AG (2001) Integrin alpha (v) beta (3) is involved in stimulated migration of vascular adventitial fibroblasts by basic fibroblast growth factor but not platelet-derived growth factor.
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Lots of researches have shown thatplateletleukocyte aggregation is very important in the formation of atherosclerotic plaque.
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Another immune thrombocytopenia is posttransfusion purpura, where immune destruction of both transfused and recipient platelets is seen, usually beginning 5 to 12 days after transfusion.
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Aggregating activity of the samples was measured over the linear portion of the calibration curve obtained with synthetic platelet activating factor.
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Fibrin and platelet thrombi were prominent in the lumina of the vessels and in the space beneath the endothelium.
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Platelets are studied in an artificial environment and the very process of preparing the platelet sample for study may affect their behaviour.
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When patients are in the hospital, "we treat them with both anticoagulants and antiplatelet drugs," said Jessica Mega , a cardiologist at Harvard-affiliated Brigham and Women's Hospital, Boston, and the first author of the Atlas study.
J&J Drug May Have New Role
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Indicated tests include a complete blood cell count with platelet count, a peripheral blood smear, and prothrombin and activated partial thromboplastin times.
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These include arteriovenous shunts, giving rise to congestive heart failure, bleeding diathesis due to platelet consumption, and massive hemoperitoneum resulting in rupture.
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It is suggested that the platelet reaction can serve as a marker of agonal stab wound and the leucocyte reaction as a criterion for timing of wounds is not feasible.
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The earliest finding is the platelet adhesion to collagen fibres followed by aggregation and formation of a platelet plug.
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The vascular effects result in tissue ischemia from vasoconstriction, platelet aggregation, and increased blood viscosity.
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In addition to the severe anemia, aplastic crises also may lead to decreased white cell or platelet counts.
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Gingko can induce decreased platelet activity, bleeding, cross-allergenicity with poison ivy; can cause cheilitis and gastrointestinal irritation.
The Best Alternative Medicine
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Increasing stomach pH in patients with an acute bleeding peptic ulcer will enhance platelet function and inhibit fibrinolysis, but do these actions result in better patient outcomes?
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Megakaryocyte capacitances were in the range of 64-694 pF, equivalent to 500-5500 platelets.
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She was treated with plasmapheresis and platelet transfusions.
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Of particular interest was phagocytosis of platelets by neutrophils.
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Your child may need blood and platelet transfusions frequently.
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It may also improve microcirculation and reduce platelet aggregation.
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It is the irreversible blockade of platelet thromboxane synthesis that results in the inhibition of platelet aggregation.
Aspirin: effects, poisoning
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In the first minute of the plug formation the platelets retain their granules and remain loosely packed.
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These results indicate that platelet activating factor may be an important factor in the progression of acute pancreatitis provoked by caerulein.
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The content of platelet activating factor in pancreatic tissue was determined using bioassay technique with washed rabbit platelets as described previously.
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Recent studies show that ibuprofen interferes with the effect of aspirin on platelet aggregation.
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Antithrombotic therapy, antiplatelet therapy, and thrombolysis are beneficial for acute coronary syndrome but harmful for aortic dissection.
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The above studies have attempted to assess the presence of circulating platelet aggregates.
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In a bag of platelets or plasma, the psoralens break down after a day, and an absorbent resin wafer in the bag removes the byproducts.
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Both cell types generated platelet activating factor activity and this was generally comparable for epithelial and lamina propria cells.
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The content of platelet activating factor in pancreatic tissue was determined using bioassay technique with washed rabbit platelets as described previously.
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Platelets were resuspended in washing buffer at appropriate concentrations for platelet aggregation measurement.
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The medical college should be provided facilities to separate all blood components such as leukocyte depleted blood, cryoprecipitate and platelet concentrate that is necessary for the treatment of blood-related diseases.
The Hindu - Front Page
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Most patients had platelet counts of less than 20,000 per mm3.
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An IV bolus of 3-5 g arginine reduced blood pressure and platelet aggregation in patients with type 1 diabetes.
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When blood is taken, it is spun in a centrifuge and the platelets separated out, with the remaining blood going back to the donor.
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This led to a substantial increase in platelet cholesterol concentration, the bulk of this increase being associated with the platelet membrane.
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Serotonin is a vasoconstrictor and uses agonists, such as ADP, epinephrine, and norepinephrine, to promote platelet aggregation.
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It also helps raise the levels of ‘good’ cholesterol and reduces platelet stickiness, helping to guard against the risk of heart disease and stroke.
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Aspirin works by preventing the production of a molecule called thromboxane, a naturally produced chemical that causes platelets to stick together and clot.
TheDenverChannel.com - Local News
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The content of platelet activating factor in pancreatic tissue was determined using bioassay technique with washed rabbit platelets as described previously.
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Lipoproteins may indirectly affect platelet function by altering vascular endothelial cell function.
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Dr Thomas Vassiliades (Emory University School of Medicine, Atlanta, GA), who voted against recommending approval, said that while the statistical analysis showed the device to be equivalent to warfarin therapy, "there were too many confounding variables, such as antiplatelet therapy, to approve.
TheHeart.org
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This drug has been proven to help keep platelets in the blood from sticking together and forming clots, which can help protect against a future heart attack or stroke.
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The petechial skin rash is related to rapid onset of thrombocytopenia. Presumably myriad fat globules become coated with platelets, thus depleting circulating platelets.
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A recently published study used thrombelastometry, plasmatic coagulation parameters and platelet count to assess the coagulation system in septic patients before and during a short-term antithrombin therapy.
PLoS ONE Alerts: New Articles
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Suboptimal smears had higher RBC count and hemoglobin level and lower platelet count in patients with myelodysplastic syndrome: refractory anemia.
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The rest of the space is taken up by plasma, white blood cells, platelets, clotting factors and other miscellaneous molecules.
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Both cell types generated platelet activating factor activity and this was generally comparable for epithelial and lamina propria cells.
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Serotonin is stored in platelets and its release stimulates thrombus formation.
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Antiplatelet agents, including aspirin and dipyridamole, should not be given within 72 hours before surgery in patients with end-stage renal disease or uremic chronic kidney disease.
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Micas provide shimmer because a mica is a flat platelet that reflects and refracts light, similar to a diamond in the sun.
Anti-Talc - Day Four - Gold Mica & Mess
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A teen boy, recently diagnosed with leukemia, retold the story of why he was hospitalized from his platelets' point of view.
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Arteries were distended and occluded by necrotic intraluminal debris, without platelet fibrin thrombi.
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• Decreases platelet "clumping" in our blood vessels
Dr. Nicholas Perricone: How Sweet It Is: Good News About Chocolate and Cocoa
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Calcifugous boiling and by abortively are righteous platelet in the pilchard, pleased allelomorph in the murray, peacefully knavishly brickyard, a immunochemical jello, and bronc gourmet on his way semantically to the vaginocele.
Rational Review
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It is composed of: red corpuscles, white cells, platelets, and blood plasma.
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The tendency to bleed too easily is often the result of a reduction in the number of platelets in the blood.
Times, Sunday Times
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Management includes anticoagulants, especially anti-platelet medications such as aspirin.
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However, it may be a sign of platelet or vascular disorders and is common in leukaemia and HIV infection.
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They use the blood to create a platelet-rich plasma, which they reinject into the area in need of treatment.
Times, Sunday Times
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Platelet-poor plasma was obtained by centrifuging each specimen at 2500g for 15 minutes.
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Cocaine enhances platelet aggregation as a result of increased levels of platelet agonists thromboxane [A.sub.2] and adrenaline.
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In P. falciparum malaria, additional laboratory findings may include mild anemia, mild decrease in blood platelets (thrombocytopenia), elevation of bilirubin, elevation of aminotransferases, albuminuria, and the presence of abnormal bodies in the urine, called urinary casts.
Malaria
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Both cell types generated platelet activating factor activity and this was generally comparable for epithelial and lamina propria cells.
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It is composed of: red corpuscles, white cells, platelets, and blood plasma.
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They are looking at why some people have blood platelets which clot inside the vessels, causing blockages, starving the heart of oxygen, leading to a heart attack.
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Concerning the biological activity, especially of the antitumour and cytotoxic nature already identified in this plant, this study identified other structures that had never been stated before and demonstrated other therapeutic activities such as antiviral, and the pharmacological effect at the level of platelet aggregation and cardiac ailments.
Chapter 12
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Similarly, fluorescent thrombin bound ubiquitously on the surface of fibrin clots, overlapping slightly with PS - exposing platelets.
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Other cell types - leucocytes and blood platelets - spend much of their time circulating freely and thus showing no adhesive interactions.
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Blood is made up of plasma, red blood cells, white blood cells and platelets.
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When a blood vessel is damaged or cut, platelets clump together and plug up the hole until the blood clots.
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Psoralen S - 59 and ultraviolet light are used together to treat individual platelet concentrates in the Helinx system, which cross links DNA and RNA.
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Some hematology instrumentation prints the red cell and platelet histograms as part of the report.
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These results indicate that platelet activating factor may be an important factor in the progression of acute pancreatitis provoked by caerulein.
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Still the lab was able to ascertain through the blood samples that the partial thromboplastin time was prolonged, yet both the prothrombin time and platelet count were normal.
Tell No One
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For these reasons studies detailing the effects of diabetic control on platelet function must be interpreted with caution.
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We want teh mass to be shrinked and her platelet count to be where it needs to be for her to get chemo.
It was then they realized - Lolcats 'n' Funny Pictures of Cats - I Can Has Cheezburger?
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The bone marrow is responsible for formation of blood components such as the white blood cells and platelets.
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Blood Research Centre, supervising research in platelet function, hypercoagulability in cancer and other disease states, and global tests of coagulation.
RedOrbit News - Technology
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Although platelet thromboxane generation was elevated in diabetics without clinical evidence of vascular disease, the difference did not reach statistical significance.
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For instance, platelets might deliver an enzyme called urokinase to selectively disintegrate blood clots.
THE MEDICAL NEWS
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Blood clots are formed by platelets - small shards of old cells which float harmlessly in the blood until they are chemically triggered to stick together in a tangle of threads of fibrin protein.
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They use the blood to create a platelet-rich plasma, which they reinject into the area in need of treatment.
Times, Sunday Times
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Salmon Salmon boast omega - 3 fatty acids. Omega - 3 s prevent platelets in the blood from clumping together.
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If the platelets are not separated, it is unlikely that the shear forces generated during the compounding process will be sufficient to overcome the forces holding the aggregates together.
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With only minor bleeding, such as epistaxis, transfusion of platelets to counts in the 30 000 to 40 000 / L range may be acceptable.
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Even when he was discharged from hospital he had to have blood and platelet transfusions twice a week for months.
Times, Sunday Times
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The increased leukocyte uPA in Quebec platelet disorder may contribute to the unique gain-of-function defect in fibrinolysis in this disorder and to the pathogenesis of joint bleeds and delayed wound healing," the researcher said.
MedPageToday.com - medical news plus CME for physicians
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Dextrans can decrease platelet adhesiveness, serum fibrinogen, and other factor levels to cause bleeding.
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The final step is fibrin clot formation, in which a sticky, thread-like substance called fibrin forms a tight mesh over the platelet plug, binding it together.
Hemophilia: stopping the bleeding
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Compressive force on the platelet, on the other hand, is a function of both the incident angle and shear rate.
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The authors used a platelet function analyser that timed platelets aggregating into a plug big enough to close a small hole in a membrane.
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About 24 hours before assay the sample was placed in 80% ethanol to extract platelet activating factor from the tissue.
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Other than aspirin, there are currently no approved antiplatelet drug therapies available to prophylactically treat companion animals with known or suspected hypercoagulability.
EurekAlert! - Breaking News
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Prostaglandins, especially prostacyclin, are secreted in all veins and have a distinct antiplatelet-aggregating property.
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Nitric oxide, a principle physiological dilator, produces local vasodilatation and inhibits platelet adherence and aggregation.
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Studies in this field are difficult to interpret due to the inherent variability of the measurements of platelet function.
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Standardized ginkgo formulas contain 24% flavonoids, and the substance, along with the other main component of ginkgo, terpene lactones, seems to keep red blood cells and platelets from forming clots.
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As a platelet is activated it can release ADP and thromboxane, both potent autocatalytic molecules.
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•low blood counts, like low white cell, platelet, or red cell counts
Burning the Fat: Fueled by Fatuousness
