How To Use Peptide In A Sentence
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This shift indicates a significant change in the peptide conformation due to the nature of the adsorbent surfaces.
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The best adequacy for EA was obtained by combinations of imipenem/cilastatin or piperacillin/tazobactam, amikacin and a glycopeptide, with values reaching 99% and 94%, respectively.
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The production of a visceral-specific anti-peptide antibody should permit a further investigation of its expression in smooth muscle cells.
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Among the amino acids of the peptide, the most dramatic change was the Phe residue.
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Above this peptide concentration, surface pressures are effectively constant.
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A peptidase enzyme capable of acting on any peptide linkage in a peptide chain.
Alcohol and The Addictive Brain
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They were focally positive for gastrin, somatostatin, and pancreatic polypeptide but tested negative for glucagon, serotonin, insulin, and inhibin.
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The major peptide fragment of AVT was AVT 1 _ 8 ( Cys - Tyr - IleGln - Asn - Cys - Pro - Arg ).
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Other functional ingredient contenders for the dairy arena include dietary fiber, whey protein isolates, whey protein concentrates, bioactive peptide systems and additional minerals and vitamins.
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They found a peptide in urine from autistics that increased platelet content of serotonin, which is also a common finding in autism.
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He adds that leptin is a very small polypeptide.
Times, Sunday Times
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The signal corresponding to the scissile +1 peptide bond could only be observed for
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They found five receptors from a family of proteins known as formyl peptide receptors.
Latest News
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The release of colonic regulatory peptides by bile salts does make physiological sense.
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The signal peptide, emerging from the ribosome, binds to the signal - recognition particle ( SRP ).
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They show considerable sequence homology to pleurocidins, antimicrobial peptides of the flounder, Pseudopleuronectes americanus.
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Finally , cyclo ( - Ab 7 - Aib - Phe ( 2 - Me ) - D - Pro - ) is successfully prepared by using liquid phase peptide synthesis with Boc protection ...
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Anastasi A, Erspamer V, Bucci M (1971) Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes.
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The purpose of digestion is to break down complex molecules into simple ones such as sugars, fats, and peptides.
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Centrally administered neuropeptide Y caused a dose-dependent increase in bile flow that was associated with an increase in biliary bicarbonate output.
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There is much interest in understanding the interaction of peptides with lipid bilayers at atomic detail.
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Renin and atrial natriuretic peptide restriction fragment length polymorphisms: association with ethnicity and blood pressure.
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The above furin-Eda-peptide (II) contains a highly reactive β-turn inducing unnatural Eda-amino acid inserted between the scissile
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Unlike larger polypeptides and proteins, small nucleic acid duplexes and hairpins do not have a dense core to which this effect would apply.
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The ability to obtain peptides of this length, from proteins of greater length, is facilitated by the use of enzymes, endopeptidases, that cleave at specific sites within the primary sequence of proteins.
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Proteins in the stomach are broken down to polypeptides by the enzyme pepsin, which works best in acidic environments and is produced by ‘chief’, or ‘zymogen’, cells in the gastric mucosa.
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The venom consists of proteins, polypeptides, and enzymes that cause necrosis and hemolysis.
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Second, small partially digested food proteins, called peptides, from gluten and casein can act to disturb the normal neurotransmitter function in the brain, and third, they can act as “excitotoxins,” increasing glutamate an excitatory neurotransmitter and creating a chain reaction that overexcites, injures, inflames and ultimately kills brain cells.
The UltraMind Solution
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-- (BUSINESS WIRE) -- Apr 8, 2009 - KAI Pharmaceuticals, Inc., a privately held drug discovery and development company, today announced the Company has initiated a third Phase 2a study of KAI-1678, a first-in-class, isozyme-selective, small peptide inhibitor of the epsilon protein kinase C pathway (epsilon PKC).
Undefined
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Neuropeptide Y has also been isolated from the gastrointestinal tract with large concentrations found in the biliary tree.
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Antibodies raised against the gene product identify a polypeptide with a relative molecular mass of about 400K in all tissues examined.
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The SS peptides are currently being tested as a treatment for cytopathic hypoxia in the ICU.
Forever Young
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PDZ-binding motifs are also present in the Tax proteins of human T-lymphotrophic (HTLV) type 1 viruses (HTLV-1) (peptide 2) that cause adult T-cell leukemia / lymphoma (ATLL), but are absent from HTLV type 2 viruses that do not cause lymphoproliferative disorders [
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We note in passing that the timescale of the peptide backbone fluctuations which interconvert open and closed conformations is on the order of ~ 1 ns even for this minimalist elastin model.
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The mammalian chorioallantoic placenta synthesizes, transports, and metabolizes a suite of steroid and peptide hormones
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On the other hand, for a system of four peptides, there are six ways to form dimers, four ways to form trimers and monomers, and only one way to form a tetramer.
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This nonspecific binding is similar to the behavior displayed by other cationic DNA-binding ligands such as cationic oligopeptides and polyamines.
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When you exercise, your rapidly beating heart releases a chemical called atrial natriuretic peptide ANP, which crosses over to the brain and directly turns off the stress response.
THE PROGRAM
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The sludge of bacterial proteins is centrifuged to separate out differing molecular weights, and the dipeptide is spun out for transfer to tankers to transport for packing and marketing at other facilities.
ASPARTAME IS NEUROTOXIC GENOTOXIC MOLECULAR FOOD & VACCINE PHARMACO-GENOCIDE
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Things that can make C-peptide higher then normal: Taking medicines, such as sulfonylurea medicines for type 2 diabetes, corticosteroids, diuretics, or birth control pills, use of alcohol, or kidney failure.
Discussion Forum - TuDiabetes - A Community for People Touched by Diabetes
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One example is the antihypertensive effect of dietary peptides derived from milk protein, mediated by angiotensin converting enzyme inhibition.
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Secondly, streptavidin is a natural tetrameric protein and each molecule has the capacity to bind four biotinylated peptides, resulting in enhanced avidity of the targeting complex to its target.
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The reason for the relatively low helicity of long peptides is unclear to us.
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It provides a complete line of peptide synthesizers and solid- and solution-phase organic synthesizers ideal for combinatorial library generation.
The Scientist
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Consequently, they proposed a compact structural motif for the entire peptide in which the [beta] sheet structure of the superhelix is a sheet with three strands connected by two turns.
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Peptides shown to bind to HLA-B53 are highlighted in bold type.
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In vertebrates, the smallest number of research citations on these peptides are commonly in the cyclostomes and elasmobranchs.
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Indeed, avoparcin, a glycopeptide structurally related to vancomycin, was widely used in Europe as a growth promoter from the early 1970s until a recent ban due to the emergence of vancomycin-resistant enterococci
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It contains four oxazole and four thiazole rings and is representative of a broad class of pharmaceutically important natural products with five-membered heterocycles derived from peptide precursors.
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PeptiVir, Inc. (Aurora, CO) is an early stage biopharmaceutical company focused on the development and commercialization of a conformationally-constrained, synthetic peptide-based vaccine platform for the prevention of viral diseases.
PRWeb - Daily News Feed
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Moreover, the stabilization of the complexes, especially the influence of the optical activity of dipeptide on the stabilization has been discussed.
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AIM:To study the gene structure encoding some antigenic polypeptides of plerocercoid of Spirometra erinaceieuropaei (SEP).
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The lower limits of sensitivity for glucagon and atrial natriuretic peptide assay were 3.7 pmol/l and 1.1 pmol/l, respectively.
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Animal studies have demonstrated that a dipeptide called carnosine not to be confused with L-carnitine not only inhibited glycation but extended lifespan, improved brain function, and even improved the appearance of rats by keeping their fur dark and glossy and reducing skin ulcers.
The Truth About Beauty
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The hope is that these peptides might compete with the virus proteins for binding to the receptor molecules.
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If all the peptides present in a single propeptide are processed and released this would lead to a complex secretagogue.
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Your rapidly beating heart also produces atrial natriuretic peptide ANP, which races over to the brain and directly shuts off the stress response originating in your limbic system.
THE PROGRAM
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Drugmakers have tried to bottle their power, but the compounds, known as antimicrobial peptides, have proven to be poor drugs.
Antibiotic Artisan
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The latter method produces 18 percent to 20 percent macropeptides, which are bioactive proteins, while ion exchange produces none.
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Vasoactive intestinal polypeptide afferents to the bed nucleus of the stria terminalis in the rat: an immunohistochemical and biochemical study.
More Parts of the Puzzle
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The production of a visceral-specific anti-peptide antibody should permit a further investigation of its expression in smooth muscle cells.
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Energy minimized 3D model structures of furin-Eda-peptide before and after Bergman cyclo-aromatization reaction were computed using hyperchem program and the structures were depicted in
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Anfinsen has shown that this information is inherent in the linear sequence of amino acid residues in the peptide chain, so that no further genetic information than that found in DNA is needed.
Press Release: The 1972 Nobel Prize in Chemistry
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The nitrated peptides were eluted with 50% acetonitrile/0. 2% trifluoroacetic acid, dried, resuspended in 1.5 µl of matrix suspension (4 mg α-cyano-4-hydroxycinnamic acid, 0.8 mg 3,5-dihydroxybenzoic acid in 50% acetonitrile/0. 1% trifluoroacetic acid, 0.1 mM fucose), and deposited on a stainless steel target.
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For the synthetic studies, we made the peptides by polymerising an activated form of the amino acid (the N carboxyanhydride) using a nucleophile as an initiator.
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Basal serum C peptide levels were measured by radioimmunoassay after an overnight fast.
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Colostrum is rich in anabolic peptides, protective antibodies and immune messengers that help the gut heal.
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Levels of N-terminal pro-B-type natriuretic peptide NT-proBNP are measured within 24 hours of admission to hospital and again at discharge to help doctors diagnose and manage patients with heart failure, which is often confused with other conditions.
Mammogram: Heart Predictor?
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Endopeptidases play key roles in storage protein degradation, producing oligopeptides.
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The sweet treat includes phenylalanine, an amino acid which stimulates a peptide hormone secreted by the brain to suppress hunger.
The Sun
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This second chamber contains an osmotically matched buffer and the test peptide in solution.
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This interaction disrupts the higher tight bond of the LPS, which allow the peptide insertion and translocation to the outer membrane inner leaflet and to the intermembrane space. rBPI
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These values can be used to estimate the total time to calculate free energies for oligopeptides of larger protein systems.
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Lipidation of bioactive peptides has been proposed as a way to increase their membrane binding, biological activity, and bioavailability.
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Results The globin hydrolysate which fully contained small molecule peptide showed the highest ACE inhibitory activity and some hemagglutinative activity with the degree of hydrolysis of 12.6%.
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Salt sensitivity in obese individuals may be a consequence of increased sympathetic activity, decreased responsiveness to atrial natriuretic peptide, activation of the renin-angiotensin system or mechanical pressure on the kidneys that increases sodium reabsorption.
Dr. Sharma’s Obesity Notes » Blog Archive » And the 2009 “Salt Lick” Award goes to Pizza!
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All the peptide sites have a mass of 160 atomic units and are uncharged.
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Both peptides have essentially identical biological activities.
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Upon measuring the absorbance of a labeled peptide at a given angle of incidence, two different dichroic ratios were obtained.
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Pert states that peptides and other informational substances are the biochemicals of emotion.
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This peptide is released by ventricular myocytes when heart failure causes increased wall stretch.
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Values range from 0 to 1 and scores equal or greater than 0.5 represent a region of the protein with RS dipeptides or basic amino acids constituting a majority.
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Now, count five beads and you have a pentapeptide.
Times, Sunday Times
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I also remember an old discussion on exorphins, defined as bioactive peptides resulting from incomplete protein digestion.
Eades/Cordain Tahoe picnic | The Blog of Michael R. Eades, M.D.
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In contrast, phosphorylations of histone H1 and GST-peptide substrates are independent of any docking site.
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Circular dichroism in 10 mM phosphate was used to determine the secondary structure and thermal stability of tropomyosin model peptides.
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Ampb peptides are a new class of molecules where the photoisomerizable dye azobenzene is linked to the peptide moiety via a flexible methylene spacer.
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Bettahi I, Nesburn AB, Yoon S, Zhang X, Mohebbi A, et al. (2007) Protective immunity against ocular herpes infection and disease induced by highly immunogenic self-adjuvanting glycoprotein D lipopeptide vaccines.
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Besides prolonging receptor-peptide interactions, acylation is found not to abolish peptide conformational flexibility and it only moderately affects the bilayer elastic properties.
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Candida albicans cell wall proteins were selected by algorithm peptide epitope searches; each was synthesized and conjugated to the fungal cell wall β-mannan trisaccharide
Proceedings of the National Academy of Sciences current issue
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Various compounds have been identified as substrates such as peptides, vinca alkaloids, anthracyclines, and epipodophyllotoxins, among others.
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The peptides are 1,000 times less allergenic than traditional cat allergen, researchers said.
Cutting Allergy Shots
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The poison of Aspartame dipeptide is a deadly neurotoxin and genotoxin.
ASPARTAME IS NEUROTOXIC GENOTOXIC MOLECULAR FOOD & VACCINE PHARMACO-GENOCIDE
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Enkephalins are flexible neuropeptides and their conformation is dependent on their environment.
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The six N-terminal amino acid residues (GVSFHP) were identical to another elasmobranch shark GRLN-LP that was recently identified although it had low identity with other GRLN peptides.
BioMed Central - Latest articles
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One peptide was designed to maximize helicity and the other, having the same composition but a different sequence, was designed to minimize helical formation.
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The average experimental residue pKs are slightly stabilized relative to what is found in small peptides with a modest standard deviation.
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This peptide collects in the brain of Alzheimer's patients and forms protein deposits which can damage and even destroy the sensitive nerve cells.
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Lysates from RGC5 cells were treated with peptide N-glycosidase F (PNGase F, for N-deglycosylation) or O-glycosidase (for O-deglycosylaton) without or with α-2 (3,6,8,9) - neuraminidase (sialidase), and Western blotted for optineurin.
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Aliquots of the peptide solution were titrated to the micelle solution to reach a peptide-to-micelle molar ratio of 1: 220.
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Finally, the efficacy of some peptide drugs and hormones can be substantially enhanced by acylation.
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Peptides can always be purchased crude and desalted, but otherwise unpurified after synthesis.
The Scientist
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Peptides shown to bind to HLA-B53 are highlighted in bold type.
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These interesting properties have made gramicidin an appropriate model for studying solvent effects on the structural changes of peptides and proteins.
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MAF controls the production of insulin, glucagon and glucagon-like peptides, which play a role both in carbohydrate metabolism as well as food intake.
Dr. Sharma’s Obesity Notes » Blog Archive » Three New Genetic Loci for Severe Obesity
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Partly it may be due to its production of the so-called enterocins, a family of bacteriocins, which are antimicrobial peptides produced by some bacterial strains.
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LMWP peptides can be produced quickly, easily, and inexpensively in large amounts from the protein protamine.
PhysOrg.com - latest science and technology news stories
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Our research on cantilever sensors - tiny levers no wider than a human hair - suggests that the cell wall is disrupted by a combination of a local antibiotic and a polymer known as a mucopeptide binding together, and the spatial mechanical connectivity of these events.
Nano Tech Wire
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These zinc-dependent endoproteases may act on a large number of substrates, or they may be highly specific, targeting only one or a few proteins or oligopeptides.
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Genome-wide surveys for simple sequences have shown that these low-complexity sequences are the most commonly shared peptide fragments in eukaryotic proteomes.
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The rapid alkalinization factor (RALF) gene is a new found plant polypeptide signal molecule, wide spreading in higher plants.
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Recently, however, several groups have studied systems of several to dozens of oligopeptides at atomic resolutions using computer simulations.
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(a) Schematic representation of linear (10) and branched (11) constructs with the scissile +1 peptide bond site-specifically labeled with
Naturejobs - All Jobs
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The opium peptide should be relative with the onset of pruritus and Vidal disease.
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A peptide release is also part of the "ileal brake" mechanism.
Hungry? Your Stomach Really Does Have a Mind of Its Own
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Platelet-derived growth factor is a major polypeptide growth factor found in human serum, platelets and fibroblasts and is a potent mitogen for cells of mesenchymal origin.
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Synthetic αK amphipathic peptide mimics the localisation of endogenous Irgm1.
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It has developed several types of resistance to vancomycin, a glycopeptide, which for decades was the MRSA drug of last resort, and is beginning to exhibit resistance to drugs in newly developed families that were intended to replace vancomycin: linezolid (Zyvox), an oxazolidinone, and daptomycin (marketed as Cubicin), a lipopeptide.
SUPERBUG
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The peptide binds to the protein noncovalently; without the dissociable peptide ligand, the MHC molecule loses its stable structure very rapidly and becomes sensitive to proteolytic degradation.
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CRH is a 41-amino acid peptide initially identified as a hypothalamic factor responsible for stimulating ACTH from the anterior pituitary (1).
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As well as the binding functionality provided by the biochemically-specific moieties they contain, the oligosaccharide might impart a steric stiffness to the polypeptide core.
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Orally active fraction of momordica charactia, active peptides thereof, and their use in the treatment of diabetes.
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Neuronal Transmission, Cellular Excitability, and Calcium Signaling The many markers involved in the assembly, function and / or regulation of neurotransmitter receptors, included several related to peptidergic, aminergic, and cholinergic signaling, and suggested that HVC is a major target of neuromodulation by these pathways (
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The LMWCr oligopeptide is composed of cysteine, glutamate, aspartate, and glycine.
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Key Neurotransmitters aMSH and CART depress feeding behavior therefore called anorectic peptides
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Vasopressin is an endogenous peptide hormone secreted by the neurohypophysis in response to an increase in serum osmolality or a decrease in plasma volume.
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A potential added benefit of such a strategy is the ability of natural antimicrobials to act synergistically with other host defense peptides and proteins.
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Normally the hypothalamus coordinates the activity of the pituitary gland through the secretion of peptides and amines.
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The soybean peptide has much branched chain amino acids and glutamine which are reported to stimulate muscle hypertrophy.
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However, for L-amino acids such as Asp or Asn, interactions between the side-chain carbonyl group with the carbonyl of the main-chain peptide bond can give rise to relative stabilisation of a conformation with a positive φ angle Box plots for the substitution scores by the class of secondary structure.
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The first, Combination A, contained an enzymatically rendered fish protein with a high level of bioactive peptides and amino acids.
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Procalcitonin, the precursor molecule of calcitonin, is a 116-amino acid peptide that is devoid of known hormonal activity.
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The membrane-associated [beta] strand structure is oligomeric, and this oligomerization can result from association of soluble peptide monomers with membranes.
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Measuring the levels of C-peptide can give a practitioner an idea of the viable beta cell mass.
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Even in the case of microbial antigens not found in vertebrates such as lipopolysaccharides, it should be noted that peptide epitopes can mimic bacterial carbohydrates and DNA.
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Abstract Molecular elasticity is associated with a select number of polypeptides and proteins, such as titin, Lustrin A, silk fibroin, and spider silk dragline protein.
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The peptide subfamily of GPCR contains receptors that bind a disparate array of peptides, such as angiotensin, bradykinin, opioid, somatostatin, and chemokines.
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None in response to Mr. Qian, while the other is loud warble: "rice Shushi drinking song of the peptide and the pillow, music also Among carry on.
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Classically, endocrine hormones are considered to be derived from amino acids, peptides, or sterols and to act at sites distant from their tissue of origin.
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Proteins with 2 or more polypeptide chains are known as oligomeric proteins, their component chains are called subunits or protomers.
Recently Uploaded Slideshows
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Our research on cantilever sensors suggests that the cell wall is disrupted by a combination of local antibiotic-mucopeptide binding and the spatial mechanical connectivity of these events.
Medlogs - Recent stories
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Earlier studies indicated that the fibrils themselves were the cytotoxic form of amyloid peptides.
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The nucleotide sequence and the polypeptide translation of the insert is shown in Fig.1.
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In addition, divalent metal adduction provided improved positive mode ionization efficiency for these peptides.
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The cells produced potent stimulation of allogenic T cells and syngeneic T cells specific for purified protein derivative in the absence of exogenous peptides.
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Agoston H, Khan S, James CG, Gillespie JR, Serra R, et al. (2007) C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and - independent pathways.
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Centrally administered neuropeptide Y caused a dose-dependent increase in bile flow that was associated with an increase in biliary bicarbonate output.
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To understand the self-assembly mechanism of a given oligopeptide, it is necessary to study the conditions under which the oligopeptides aggregate and further develop into macrostructures.
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Salts and PDB above diluent threshold concentrations inhibit the effect of antimicrobial peptides on the germination of conidia, therefore all these quantitative assays were performed in a 50-fold diluted modified PDB.
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Serum levels of atrial natriuretic peptide, brain natriuretic peptide, norepinephrine and other neurohormones are elevated in patients with heart failure.
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To study efficiency of nucleoside peptide nutrient on antioxidation function of rat by 3 dosage group.
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Besides the long-range interactions it makes with neighboring protease residues, the binding affinity of a peptide also depends on its own conformation.
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The conclusion of this study was that eating at a moderate rate produces an increased anorexigenic gut peptide response, compared to eating at a rapid rate.
Georgianna Donadio, MSc, Ph.D., D.C.: Chew Your Way to Losing More Body Fat
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The LDL receptor is a polypeptide of 839 amino acids that spans the plasma membrane.
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The protein source of peptide-based formulas is hydrolyzed protein, dipeptides or tripeptides, or free amino acids.
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The hope is that these peptides might compete with the virus proteins for binding to the receptor molecules.
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Another class of novel mitochondrial antioxidants that play a key role in the treatment of cytopathic hypoxia is the amino acid peptide-based antioxidants.
Forever Young
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AIM: To study the binding sites of ZNC (C ) PR, a C-terminal pentapeptide fragment of argipressin, in rat brain.
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Have you been given immune globulin, IFN, thymic peptide, TF, immunodepressant , etc. within 3 months?
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What is the complete sequence of amino acids in this polypeptide? ortho-nitrophenol is steam volatile while para-nitrophenol is not. what is the reason behind this? en Español
Yahoo! Answers: Latest Questions
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In particular, the isolation of separate bullfrog and dogfish shark gastrin- and CCKlike peptides suggests that gastrin evolved much earlier than originally hypothesized.
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Intranasal calcitonin is a polypeptide hormone that also inhibits osteoclastic activity.
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This chain ended in a free sulfhydryl group, which stuck to modified glass beads as the peptides filtered through them.
The Scientist
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In the 1950s to 1970s, molecular biologists were sure that each DNA sequence could not encode more than one polypeptide chain.
James A. Shapiro: DNA as Poetry: Multiple Messages in a Single Sequence
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AIM: To study the effect of calcitonin gene related peptide (CGRP) on contraction and relaxation of iliac artery transduced with CGRP gene by retrovirus vector.
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They could have made up one or more peptide sequences, running left to right, top to bottom, or in some other fashion, if arranged properly.
VITALS
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The purpose of the study was to analyze the cecropin antibacterial activity and different component of antibacterial peptide in different growth stages.
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Peptide nucleic acids ( PNAs ) constitute an attractive new class of probes, recently introduced in cytogenetics.
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Ablation of capsaicin sensitive afferent neurones was verified by a depletion of calcitonin gene related peptide from the gastric corpus wall.
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They work hand in hand, one after the other and act like scissors, cutting up this [APP] protein into smaller bits and smaller bits called amyloid peptide, which we think is the cause of Alzheimer's disease when it's abnormally accumulated in the brain," explained study senior author Philip C. Wong, a professor of pathology and of neuroscience at Johns Hopkins University School of Medicine in Baltimore.
Medlogs - Recent stories
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The focus then shifts to a systematic presentation of the various substrates classes, namely carboxylic esters, amides and peptides, lactams and lactones, esters of inorganic acids, alkene and arene epoxides, and some miscellaneous hydrolyzable moieties.
The Earth Times Online Newspaper
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We and others have found that IFN-gamma and other pro-inflammatory cytokines interact with processing and production of the pathological hallmark feature of Alzheimer's disease (AD); A-beta peptide; suggesting that inflammaging may be a "prodrome" to AD.
BioMed Central - Latest articles
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For the mixed monolayers, peptide and lipid were premixed in the desired proportions from their respective pure solution, and then directly spread on the surface.
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D. Searle chemist who, when he was trying to create an anti-ulcer drug, combined two amino acids, aspartic acid and phenylalanine and found that the resulting dipeptide (a molecule consisting of two amino acids) had an intensely sweet taste to the tongue.
Duty to Warn: Diet Coke is Poison
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Snake venoms are a complex mixture of proteins, polypeptides, biogenic amines, and other components that may have neurotoxic, hemostatic, and/or hemorrhagic effects on prey.
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All of these enzymes recognize specific four-residue sequences and cleave peptide bonds located strictly after an Asp group.
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Getty Images A new vaccine uses synthetic peptides that are 1,000 times less allergenic than traditional cat allergen.
Cutting Allergy Shots
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AIM: To explore the immunosuppressive effects of a novel HLA-derived peptide, RDP1258, on rat splenocyte proliferation in vivo and its underlying mechanisms.
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A feasible way to decrease the risk of insertional mutagenesis is to combine the reprogramming factors into a single polycistronic vector by inserting a 'self-cleaving' 2A peptide or an internal ribosome entry site (IRES) sequence between two consecutive open reading frames.
BioMed Central - Latest articles
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It is a basic protein with a single polypeptide chain and acts on cellular and model lipid membranes.
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Here viruses that infect bacteria, called phage, are engineered such that each virus has on its surface coat a unique random peptide.
NPR Topics: News
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Apparently the monocyclic geometry leads to stronger interactions between peptide and chromophore extending also to longer times.
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The addition of natriuretic peptide measurements and electrocardiography further increases the accuracy of the diagnosis
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Many hormones are of a polypeptide nature, and in 1955 Vincent du Vigneaud of Cornell University was given the prize for his synthesis of two such hormones, vasopressin and oxytocin.
The Nobel Prize in Chemistry: The Development of Modern Chemistry
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Objective: To observe the ultrastructural pathological changes and the localization of pituitary adenylate cyclase-activating polypeptide(PACAP)in rats after spinal cord injury(SCI).
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Galanin, cocaine and amphetamine regulated transcript peptide (CART) and melanin concentrating hormone (MCH), etc. , which were related to the regulation of appetite, were expressed in pituitary.
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Peptide transport activity appears in the scutellum of barley seeds after 6-12 h imbibition, before any visible signs of germination, and increases rapidly to a maximum around 24 h imbibition.
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We have also assessed behavioural and cell-signalling responses to exogenous leptin and the density of immunoreactivity for orexigenic and anorexigenic peptides in the hypothalamic paraventricular nucleus (PVH) prior to the onset of hyperphagia.
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It reduces experimental uncertainties, averages out random error, and assures that OBPC is isomorphous with DOPC in the presence and absence of the peptide.
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Better prognosis has been documented in patients with CHF being treated with diuretics and vasodilators when the b-type natriuretic peptide level decreases.
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Two possibilities are that peptide inserts as a monomer and transposes its environment to initiate aggregation into oligomers/protofibrils or that the peptide oligomerizes and then inserts into membranes to stabilize itself.
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Galanin is a brain chemical called a neuropeptide, which previous research has identified as crucial to determining appetite for carbohydrate and fat-rich food.
Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph
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This greatly reduces errors in polypeptide chain elongation, and is therefore highly favored by natural selection.
Always finish what you start…
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It has developed several types of resistance to vancomycin, a glycopeptide, which for decades was the MRSA drug of last resort, and is beginning to exhibit resistance to drugs in newly developed families that were intended to replace vancomycin: linezolid (Zyvox), an oxazolidinone, and daptomycin (marketed as Cubicin), a lipopeptide.
SUPERBUG
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A variety of antimicrobial peptides are present in mammals.
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Although C-type natriuretic peptide lacks natriuretic action, it has marked vasodilatory and growth-inhibiting properties.
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The lower efficiency of surfactants with large headgroups can be understood as a steric effect, where a bulky headgroup sterically hinders the hydrophobic residues on the peptide from interacting with the micelle core.
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Cnidarians contain chemical synapses and release neurotransmitters, including biogenic amines and peptides.
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My own training is in the field of neuroendocrinology and I really became very fascinated many years ago with the molecules of emotion, molecules that we call neuropeptides.
Deepak Chopra: Interview with Alva Noe, Ph.D.
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Depending upon the site of transcription, the calcitonin gene yields an RNA that synthesizes calcitonin or calcitonin-gene related peptide.
