How To Use Peptidase In A Sentence
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In 1929 he isolated pepsin in pure crystalline form by techniques which were later used by himself and other workers to crystallize trypsin, chymotrypsin, carboxypeptidase, and pepsinogen.
John H. Northrop - Biography
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Their action ends when endopeptidases in the kidney or blood vessels inactivate them.
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The number of proteases, peptidases, and other exoenzymes produced by S. miilans clearly suggests that it derives resources from host tissues.
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M1 aminopeptidase activity is such a fundamental process that it's been conserved evolutionarily.
Softpedia News - Global
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Both pills work by inhibiting an enzyme called dipeptidyl peptidase 4 DPP-IV, which breaks down hormones that help control blood sugar.
Merck, Novartis Square Off In Diabetes DuelDiabetes Duel
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Aminopeptidases and oligopeptidases in the cytosol may cleave oligopeptides into free amino acids.
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Some of the preexisting protein translocation apparatus of the endosymbiont appears to have been commandeered, including molecular chaperones, the signal peptidase, and some components of the protein-targeting machinery.
3 recent reports use evolution to study mechanisms of antibody diversification - The Panda's Thumb
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Trypsin also activates trypsinogen as well as all the other proenzymes in the pancreatic secretion, producing the active proteases and peptidases that hydrolyze dietary polypeptides.
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The new investigation was conducted using the aminopeptidase M1 protein (APM1), usually found in plants, and a similar, human protein, called insulin responsive aminopeptidase, or IRAP, PhysOrg reports.
Softpedia News - Global
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Objective To establish kinetic assay method for alanine aminopeptidase(AAP)in serum, be applied to clinical diagnosis primarily.
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Recent comments by Dr. Daniel Drucker, a professor at the University of Toronto and leader in diabetes and endocrinology, suggested dipeptidyl peptidase agents such as those being developed by Merck and Novartis have potential as effective second-line treatments for type 2 diabetes, according to Morgan Stanley.
Merck's Januvia Has 'Huge' Commercial Potential For Diabetes
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Objective: to investigate the variation and significance of urinary alanine aminopeptidase ( AAP ) in nephrotic syndrome.
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The peptidase activities in the gingival fluid were maintained at lower levels during the experimental period in the test sites, while it reached 70% of that at baseline in the placebo sites.
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University, who worked at that time on translocation of proteins across the endoplasmic reticulum (ER) membrane, a process that involves cleavage of the leader peptide by signal peptidase, to Jeffrey Roberts in Cornell University who worked on E. coli RecA protein-directed cleavage of phage l repressor and its requirement for polynucleotide, and to Harvey Lodish at the M.I.T. who worked, among other subjects, on processing of viral polyproteins.
Aaron Ciechanover - Autobiography
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Scientists in Hong Kong had been studying samples of liver tumor cells and found that some of the cells contained high levels of a variant of the protein Carboxypeptidase E or CPE.
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University, who worked at that time on translocation of proteins across the endoplasmic reticulum (ER) membrane, a process that involves cleavage of the leader peptide by signal peptidase, to Jeffrey Roberts in Cornell University who worked on E. coli RecA protein-directed cleavage of phage l repressor and its requirement for polynucleotide, and to Harvey Lodish at the M.I.T. who worked, among other subjects, on processing of viral polyproteins.
Aaron Ciechanover - Autobiography
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The monomorphic loci were: isocitrate-dehydrogenase, diaphorase (E.C.1.6.99.-, loci Dia1 and Dia2), leucine aminopeptidase and peroxidase anodic.
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Slide 11: ENZYMES THAT REFLECT CHOLESTASIS • Alkaline phosphatase and 5 'nuleotidase: found near the bile canalicular membrane of hepatocytes • Gamma Glutamyl Transpeptidase: Endoplamic reticulum and in bile duct epithelial cells lacks specificity
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The proteases are secreted in forms of zymogen (ie, inactive precursor to enzyme), such as trypsinogen, chymotrypsinogen, and procarboxypeptidase.
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Such specificity effects originating from side-chains distal from the scissile N-terminal peptide bond are, to our knowledge and up to date, unique to this aminopeptidase and have only been partially observed before as differential substrate specificity depending on the C-terminus of an unrelated series of peptides
PLoS ONE Alerts: New Articles
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CD26/dipeptidyl peptidase IV: A regulator of immune function and a potential molecular target for therapy.
The UltraMind Solution
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In 1929 he isolated pepsin in pure crystalline form by techniques which were later used by himself and other workers to crystallize trypsin, chymotrypsin, carboxypeptidase, and pepsinogen.
John H. Northrop - Biography
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The ability to obtain peptides of this length, from proteins of greater length, is facilitated by the use of enzymes, endopeptidases, that cleave at specific sites within the primary sequence of proteins.
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Some bacteria naturally have more of these protease and peptidase enzymes than other bacteria, so careful characterization is necessary to select the strains with the highest level of the desired enzymes.
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It was not until the mid-1990s that researchers saw another way: An enzyme called dipeptidyl peptidase four DPP4 broke down GLP, and by inhibiting it, researchers could boost GLP levels in the body.
Merck Starts Diabetes Race
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This category contains phospholipids, proteolytic enzymes, proteinases, proteases, and peptidases.
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Endopeptidases play key roles in storage protein degradation, producing oligopeptides.
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Those results, as well as data on a class of drugs known as dipeptidyl peptidase IV inhibitors DPIV, could provide a catalyst for OSI shares, the Wachovia analyst said.
OSI's Macugen Still Burdened By Lucentis Threat
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New evidence showing that stored endopeptidases start storage protein mobilization in germinating seeds of these plants
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All of the serine proteases and the zinc peptidases of pancreatic secretions are produced in the form of their respective proenzymes.
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Since MMPs are zinc-dependent endopeptidases, we speculated that the reduction of BP7033Br ALK effect could be due to a reduction of available phosphonic acid groups able to chelate zinc and consequently inhibit MMPs.
PLoS ONE Alerts: New Articles
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During experiments, Wendy Peer, a research assistant professor of horticulture, found that inserting a similar protein found in humans, called insulin responsive aminopeptidase, or IRAP, also rescued the plants.
PhysOrg.com - latest science and technology news stories
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A peptidase enzyme capable of acting on any peptide linkage in a peptide chain.
Alcohol and The Addictive Brain
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This will facilitate the further study on the funtion of carboxypeptidase related to fitness cost at protein and immune level.
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The most frequently used biological molecules included in the digestion models were digestive enzymes (pancreatin, pepsin, trypsin, chymotrypsin, peptidase, α-amylase, and lipase), bile salts, and mucin.
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Pancreatic trypsin is a member of the large and diverse serine peptidase family.
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Once inside the stroma, the transit sequence is cleaved off by the stromal processing peptidase.
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Glutamyl peptidase activity has been detected in leaves, roots, and bulbs of growing onions, but not in dormant bulbs of variety Southport White Globe.
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Osborne, who expects FDA approval of Novartis' Galvus in the first quarter, is one of a handful of analysts who believe Byetta will see significant competition from a new class of diabetes treatments known as dipeptidyl peptidase inhibitors.
Amylin Gets Euro OK For Byetta, Shares Fall
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This enzyme may also act as a glutamyl peptidase, requiring only water as an acceptor.
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The aminopeptidase M1 protein, or APM1, is critical for root development in plants.
PhysOrg.com - latest science and technology news stories
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These proteases are both endopeptidase and exopeptidase, and their combined action in the intestine leads to the production of amino acids, dipeptides, and tripeptides, all of which are taken up by enterocytes of the mucosal wall.
