How To Use Nitric oxide In A Sentence
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It works by affecting a molecule called nitric oxide, which expands blood vessels.
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Nitric oxide (NO) Containing in hu manis expiratory gas is the important messenger and effector in the organism.
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Nitrates act as donors of nitric oxide, a molecule with a recognized potential for genotoxicity.
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Effect of inhaled nitric oxide in premature infants on tracheal aspirate and plasma nitric oxide metabolites.
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They found that smoking during pregnancy lowers production of an enzyme called endothelial nitric oxide synthase (eNOS), which regulates blood vessel dilation.
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Nitric oxide is a free radical that promotes infection resistance and blood vessel dilation.
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Nitric oxide, nitrates, and sulfa-containing drugs are the most frequent precipitants of clinically important methemoglobinemia.
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Nitric oxide is involved in vasodilatation (dilation of the blood vessels).
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185, 960-966 (1992) [9] White, K.A.; Marletta, M.A.: Nitric oxide synthase is a cytochrome P-450 type hemoprotein.
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Subtracting from the total amount of permanganate thus used the quantity required to equalize the 100 c.c. of solution No. 1 and the 100 c.c. of the manganous sulphate, we shall have the quantity of permanganate reduced by the nitric oxide.
Scientific American Supplement, No. 561, October 2, 1886
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Feelisch, M. and Schmidt, H. H. (2000) Electronparamagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase.
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In conducting these experiments, we discovered that the non-nitric oxide containing substance, protoporphyrin
Louis J. Ignarro - Autobiography
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Nitric oxide, nitrates, and sulfa-containing drugs are the most frequent precipitants of clinically important methemoglobinemia.
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I recall reading an interesting paper by Ferid Murad's group in 1977, in which nitric oxide and various nitro compounds were shown to activate the cytosolic form of guanylate cyclase and to elevate cyclic GMP levels in various tissues.
Louis J. Ignarro - Autobiography
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Bealer JF, Natuzzi ES, Buscher C, Ursell PC, Flake AW, Adzick NS, Harrison MR: Nitric oxide synthase is deficient in the aganglionic colon of patients with Hirschsprung's disease.
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This application of topical nitric oxide may stimulate wound fibroblasts to increase collagen synthesis and remodeling.
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The dilatory effect of chocolate under resting conditions can be attributed to improved nitric oxide bioavailability, prostacyclin increase, direct effect of chocolate in smooth muscle cells, or activation of central mechanisms," they write.
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Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise.
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In one trial, inhaled nitric oxide reduced the need for extracorporeal membrane oxygenation in neonates without increasing neurodevelopmental, behavioral or medical abnormalities at two years of age.
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Because it's difficult to grow blood vessels in the laboratory, investigators have struggled to identify the molecules that convert nitroglycerin into nitric oxide.
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The problem didn't affect the flow of nitric oxide from the device, the company said, but it could cause the device to show fluctuating concentrations of the gas.
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Nitrates are best detected and determined by their yielding nitric oxide when treated with sulphuric acid and a suitable reducing agent, such as ferrous sulphate, mercury, or copper.
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Researchers from the University of Kentucky Medical School and Taishan Medical College report that high salt levels in the blood, as would be observed in people with high salt intake, could significantly suppress the activity of an enzyme called nitric oxide synthase (NOS).
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Two kinds of motor nerves, excitatory nerves that release acetylcholine and inhibitory nerves that release nitric oxide, account for all events that occur in smooth muscle of the esophagus in a swallow.
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Production was not abrogated by inhibitors of cyclooxygenases, xanthine oxidase, nitric oxide synthases, and mitochondrial enzymes.
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IN 1997 the European Patent Office (EPO) gave a patent to Massachusetts General Hospital for its use of nitric oxide to treat bronchoconstriction, a method often used for “blue baby” syndrome.
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Nitric oxide stimulates collagen synthesis and subsequent healing at wound sites.
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In these reactions the ozone reacts with nitric oxide to produce nitrogen dioxide.
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Li H, Meininger CJ, Hawker JR Jr, Haynes TE, Kepka-Lenhart D, et al. (2001) Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells.
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He isolated around twenty different airs, including hydrogen chloride, nitric oxide, and ammonia.
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IN 1997 the European Patent Office (EPO) gave a patent to Massachusetts General Hospital for its use of nitric oxide to treat bronchoconstriction, a method often used for “blue baby” syndrome.
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J.F.; Roberge, A.G.: Nitric oxide synthase in cat brain: cofactors - en - zyme-substrate interaction.
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TNF and nitric oxide are known death liver damage inducers, producing esteatosis between parenquimal cells which can result in death cell.
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at concentrations attainable after moderate wine intake" could stimulate the production of nitric oxide, a compound known as a vasodilator, which can lead to blood vessel relaxation, reductions in blood pressure, and improvements in heart health.
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By depositing proteins as monolayers onto gold colloids, the aim will be to develop biosensors for nitrate and nitric oxide with detection capabilities approaching those of natural bacterial cells.
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However, watermelon is loaded with a nutrient called citrulline, which helps produce nitric oxide, a powerful blood vessel dilator that's critical to healthy blood flow.
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New research finds that nitric oxide accumulation in the brain's basal forebrain is both necessary and sufficient to produce sleep, providing a completely new basis for developing drugs that help people stay awake -- or, conversely, sleep.
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It is formed from the reaction of nitric oxide with superoxide, and produces carbonyls on proteins.
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Nitric oxide can react with superoxide yielding peroxynitrite, an oxidizing agent that induces lipid peroxidation, sulfhydryl oxidation of proteins, and nitration of aromatic amino acids.
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Sure, there are other nitric oxide generators out there, all claiming some sort of delivery system.
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Because it's difficult to grow blood vessels in the laboratory, investigators have struggled to identify the molecules that convert nitroglycerin into nitric oxide.
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The inhibitor of nitric oxide synthase failed to inhibit this response, and it also did not potentiate the reflex cholinergic contractions of the trachea produced by bradykinin.
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Nitric oxide and nitrogen dioxide were chemically assayed as nitrite from sorbent tubes by using spectrophotometry.
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In addition, a nitric oxide-dependent mechanism is responsible for mediating neurogenic vasodilatation and for regulating functions of the respiratory, genitourinary, and gastrointestinal tracts.
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John Garthwaite had just reported that nitric oxide was a neuro transmitter in the brain, and we wondered whether or not nitric oxide could be the neurotransmitter in the so called nonadrenergic noncholinergic neurons that were known to innervate the corpus cavernosum smooth muscle.
Louis J. Ignarro - Autobiography
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Objective:The study was performed to evaluate the effect of ischemic preconditioning on the coronary reactive hyperemic response and further exploit the role of nitric oxide (NO)in the process.
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In both cases the nitric oxide is produced by a reaction from a chemical called L-arginine. The chemical reaction is catalysed by an enzyme called nitric oxide synthase.
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There is evidence that insulin resistance decreases the synthesis of nitric oxide.
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It is known that Salmonella and E. coli can produce the potent cytotoxin nitric oxide as a side product of nitrate metabolism.
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Biosynthesis of NO involves oxidation of the guanidine group of arginine with stoichiometric formation of citrulline by the enzyme nitric oxide synthase.
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Objective To study of the effect of nitric oxide ( NO ) in brain on pain threshold of rats.
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Endothelial cells manufacture a magical protective molecule of gas called nitric oxide, which protects our blood vessels.
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Gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide.
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Fructose-fed rats showed significantly impaired glucose tolerance, impaired insulin sensitivity, hypertriglyceridemia, hypercholesterolemia, hyperhomocysteinemia (HHcy), lower total antioxidant capacity (TAC), lower paraoxonase (PON) activity, and higher nitric oxide metabolites (NOx) concentration, when compared to rats fed on control diet.
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The responsible nerves appear to include both excitatory cholinergic fibers and inhibitory fibers that probably release nitric oxide.
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Title: Effect of the influenza A (H1N1) live attenuated intranasal vaccine on nitric oxide (FEno) and other volatiles in exhaled breath
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The pill is unfortunately too expensive to serve as a food preserver, but researchers are already working on a cheaper nitric oxide vehicle.
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Thus, for example, it seems impossible for nerve terminals to store a significant amount of an unstable and highly diffusible gas like nitric oxide: it must be synthesized on demand and diffuse instantly into the synaptic space.
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The palladium catalysts outperformed the platinum ones in nitric oxide and propene conversion; however, they fell short in the processing of propane unless the temperature was above 320 ºC (600 ºF).
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Nitric oxide has a beneficial effect on circulatory status and increases blood supply to the wound.
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Nitric oxide release was quantified using the Griess chemical method as previously described The toxicity of noscapine or its analogs was determined by assessing cellular viability and proliferation using trypan blue exclusion method
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Results Nitric oxide was directly toxic to PC12 cells in a dose-dependent manner, and brain tissue homogenate extracts taken from hypoxia preconditioned mice could prevent PC12 cells from NO toxicity.
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Through cell culture and mouse experiments, the researchers found that a protein called thrombospondin-1 (TSP1) and its receptor, CD47, inhibit activation of the endothelial-based enzyme called endothelial nitric oxide synthase (eNOS), which in turn limits the production of
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Inhaling deeply brings a chemical called nitric oxide from the back of your nose and your sinuses into your lungs.
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One molecule of permanganate equals one molecule of nitric oxide when manganous sulphate is used, since no part of the permanganate employed in this method is reduced below the superoxide condition.
Scientific American Supplement, No. 561, October 2, 1886
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Recent studies have investigated the source and target neurons for the diffusible neuronal messenger molecule nitric oxide in the nervous system of the locust.
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The authors speculate that HVPC reverses wound area expansion and increases microcirculation by release of nitric oxide in the microenvironment.
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Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise.
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In both cases the nitric oxide is produced by a reaction from a chemical called L-arginine. The chemical reaction is catalysed by an enzyme called nitric oxide synthase.
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Dr. Miller says a compound called nitric oxide is known to play a role in the dilation of the endothelium.
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Objective:To locate nitric oxide synthase (NOS) in the chicken vestibular system.
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We purchased a small cylinder of nitric oxide gas, made a dilution in nitrogen (nitric oxide is very unstable in the presence of oxygen), and injected a fine stream of gas bubbles into an organ bath in which was mounted a strip of bovine coronary artery precontracted by addition of phenylephrine.
Louis J. Ignarro - Autobiography
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Inhibition of nitric oxide synthase abolished the basal levels of exhaled nitric oxide, and also decreased the exhaled nitric oxide response to all compounds except nitroglycerine.
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Other promising therapies include butyrate compounds, clotrimazole, magnesium supplementation, poloxamer 188, antiadhesion agents, anticoagulant approaches, and nitric oxide....
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However, watermelon is loaded with a nutrient called citrulline that helps produce nitric oxide, a powerful blood vessel dilator that’s critical to healthy blood flow.
You: On a Diet
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Nitric oxide (sometimes called nitrogen monoxide) has the chemical formula NO.
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The effects of the nitric oxide synthase inhibitor on the response to histamine were mimicked by vagotomy or selective nerve blockade with tetrodotoxin.
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The condition, called endothelial dysfunction, involves a loss of nitric oxide in the endothelium, the layer of cells that line blood vessels.
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Slow transmission can take many minutes and is enormously more complex, involving at least 100 different chemicals falling into four classes: biogenic amines, peptides, amino acids and nitric oxide.
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Anole splenocytes were phagocytically active and produced copious amounts of nitric oxide following exposure to fluorescein labeled E. coli bioparticles.
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Nitric oxide, a principle physiological dilator, produces local vasodilatation and inhibits platelet adherence and aggregation.
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The thiol group of s-nitrosothiol essentially protects nitric oxide from being scavenged by the binding site on heme.
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The effects of the nitric oxide synthase inhibitor on the response to histamine were mimicked by vagotomy or selective nerve blockade with tetrodotoxin.
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Conclusions:TCM herbs with activating the spleen can regulate nitric oxide standard in infant anorectic rat's gastric antrum and colon.
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Using sodium nitroprusside as a nitric oxide(NO) donor, the effect of different concentration of SNP treatment on sensory and internal quality of lima bean pod was investigated.
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a specific isoform of cyclic GMP phosphodiesterase and allowing cyclic GMP to accumulate when guanylate cyclase is activated by nitric oxide released from the nerves innervating the erectile tissue.
Louis J. Ignarro - Autobiography
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Nitric oxide also inhibits proliferation of smooth muscles, reduces leukocyte adhesiveness, and regulates endothelial permeability, to lipoproteins and other constituents of plasma.
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Nitric oxide can react with superoxide anions to produce peroxynitrite anions, thus quenching the biological effects of NO.
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Recently, it has been suggested that nitric oxide produced during an inflammatory response could become an endogenous cytotoxin, with mutagenic and/or carcinogenic properties.
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Administration of gadolinium chloride and aminoguanidine decreased the levels of nitric oxide and cyclic guanosine monophosphate, and inhibited the changes in alveolar fluid clearance.
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Wheat seeds(Triticum aestivum L. cv. DK 961) were pre-soaked with nitric oxide donor sodium nitroprusside(SNP) to study effect of exogenous NO on oxidative damage in wheat seedlings under salt stress.
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Similar to nitrous acid, nitric oxide gives rise to reactive nitrous anhydride that can induce nitrosative deamination of DNA bases.
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Using sodium nitroprusside as a nitric oxide(NO) donor, the effect of different concentration of SNP treatment on sensory and internal quality of lima bean pod was investigated.
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The advantage of this method lies in the fact that it is not necessary to dissolve the oxide which is precipitated upon the glass within the tubes, E, E, since, in the presence of an excess of permanganate, the reduction by nitric oxide extends only to the formation of MnO_ {2}; also in the fact that the solution of manganous sulphate is more stable than that of oxalic acid.
Scientific American Supplement, No. 561, October 2, 1886
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The cytokines, in turn, cause the formation of nitric oxide that combines with superoxide to form the potent oxidant peroxynitrite, thus continuing the cycle.
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By depositing proteins as monolayers onto gold colloids, the aim will be to develop biosensors for nitrate and nitric oxide with detection capabilities approaching those of natural bacterial cells.
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Supplements don't contain nitric oxide but some promote its production in the body - products containing arginine or the tropical fruit noni, for example.
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Nitrogen dioxide is a brown gas, transformed from nitric oxide contained in emissions.
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Objective To study the clinical significance of changes of plasma nitric oxide (NO) and tumor necrosis factor (TNF) levels in patients with congestive heart failure (CHF).
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Objective To study the effects of nitric oxide(NO) in basolateral amygdaloid nuclei(BLN)on sleep and behavioral activity in rats.
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Thus, organic nitrates such as glyceryl trinitrate may be viewed as prodrugs of endogenous nitric oxide.
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Inhibition of nitric oxide synthase abolished the basal levels of exhaled nitric oxide, and also decreased the exhaled nitric oxide response to all compounds except nitroglycerine.
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Biological chemistry and molecular mechanisms of action in nitric oxide
Clinical and basic research
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Documented functions of HBs include storage and transport of oxygen, nitric oxide detoxification, and facilitating oxygen diffusion in symbiotic tissues.
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The endothelium produces several regulatory mediators, including nitric oxide and prostacyclin, which are vasodilators, and endothelin, which is a vasoconstrictor.
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It induces the production of nitric oxide and inhibits the activation of monocyte chemoattractant protein.
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This endogenous nitric oxide can lead to de-repression of the genes encoding systems that are concerned with the detoxification of nitric oxide and the repair of proteins potentially damaged by the cytotoxin.
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Hollenberg SM, Cunnion RE, Zimmerberg J. Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to catecholamines in septic rats.
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Nitric oxide is generated by the thermal decomposition of nitrites and nitrates.
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Thus, organic nitrates such as glyceryl trinitrate may be viewed as prodrugs of endogenous nitric oxide.
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Teramoto et al raise the interesting point that an increase in nitric oxide is responsible for a poor or absent hypoxic pressor response as a cause of hypoxemia.
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Variants of two genes were associated with increased risk of kidney cancer: nitric oxide synthase 2A (NOS2A), which increases levels of nitric oxide, a chemical that promotes free radical damage to cells; and prostaglandin-endoperoxide 2 (PTGS2), which produces prostaglandins, compounds that cause inflammation.
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By modulating the effects of key pro-inflammatory molecules, including cyclooxygenase 2, leukotrienes, prostaglandins, nitric oxide, interferon-inducible protein, tumor necrosis factor TNF, and interleukin-12, the curcuminoids in turmeric suppress inflammation.
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