How To Use Monoclonal In A Sentence
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Dengue 1-4 Antigen + conjugated monoclonal antibodies = antigen-MAb complex Sandwich of anti-human IgG antibody / Serum Antibody / antigen-MAb complex AI >
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Dengue 1-4 Antigen + conjugated monoclonal antibodies = antigen-MAb complex Sandwich of anti-human IgM antibody / Serum Antibody / antigen-MAb complex
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One recent publication showed that EMT mediated loss of contact inhibition in hepatocarcinoma cells, and reexpression of E-cadherin restored cell-cell contacts Mouse monoclonal antibodies were used to detect E-cadherin (BD Transduction Labs.,
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Rabbits used to raise polyclonal Ab are nearly always exsanguinated at the final bleed, and anything used to make monoclonals is sacrificed as part of the procedure.
Can an animal rights activist accept medical treatment invented through animal testing?
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Most scientists working with the new inhibitors and monoclonal antibody treatments acknowledge they will be used in combination with chemotherapy for years yet.
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Flow cytometric immunophenotyping did not reveal an aberrant T cell or monoclonal B-cell population.
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As a control, sections were incubated with phosphate buffered saline instead of the primary monoclonal antibodies in the first step.
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It has developed proprietary monoclonal antibodies to properdin that are potent in vitro and in vivo inhibitors of the complement alternative pathway.
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Affimed's proprietary and highly productive TandAb® technology enables the company to generate unique tetravalent, bispecific, fully human antibody formats that promise increased therapeutic potential and superior profiles compared to monoclonal antibodies.
Reuters: Press Release
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DSM contract manufacturing services include: chemical development, registered intermediates, registered starting materials, active pharmaceutical ingredients API's, mammalian cell production of monoclonal antibodies and proteins, formulation development, clinical trial manufacturing and finished dose form manufacturing of solids, semi-solids, and scheduled drugs, aseptic liquid and lyophilized products.
DSM and Codexis Sign Enzyme Supply Agreement - Yahoo! Finance
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Herein, we report a case of monoclonal B-cell proliferation involving lymph nodes, bone marrow, and peripheral blood in a patient with Whipple disease.
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The monoclonal against HER2 receptor is ineffective in prostate cancer which may be explained by the presence and the potential effect of HER2 C-terminal fragment.
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Radial water flow was induced by application of a pressure gradient of - 0.06 MPa. Sections were incubated with monoclonal ABA antibodies and with the secondary Alexa 568 antibodies and stained with aniline blue and toluidine blue.
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Goronzy J, Weyand CM, Fathman CG (1986) Long-term humoral unresponsiveness in vivo, induced by treatment with monoclonal antibody against L3T4.
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A monoclonal antibody to influenza nucleoprotein was purchased from QED Biosciences (San Diego, CA).
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Methods:Monoclonal and poly - clonal dual antibody sandwich method was used to assay the levels of serum interleukin - 2 (IL - 2 ) and soluble interleukin - 2 receptor (SIL - 2R) .
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These technologies effective addressing monoclonal antibody questions and so on mouse source.
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A prospective study was then undertaken using serum from 100 consecutive patients with various monoclonal gammopathies and from 13 patients with polyclonal hypergammaglobulinemia and cryoglobulins.
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Whether polyclonal proliferations progress to monoclonal lymphomas has not been proven.
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Do patients fare better when they're told they suffer from POEMS, or the Crow-Fukase syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes?
Operation SMARM
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Stable class I molecules were recovered with the monoclonal antibody W6/32.
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Review of the flow cytometric immunophenotypic data failed to reveal a monoclonal B-cell or aberrant T-cell population.
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This first-in-class monoclonal antibody targets RANK ligand, which is involved in bone-degenerating osteoclasts.
PharmaTimes World News
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The presence of parathyroid tissue was confirmed by positive immunoreactivity with a monoclonal antibody to parathormone.
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Naked monoclonal antibodies are those without any drug or radioactive material attached to them.
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Scientists have also used monoclonal antibodies to'see " hidden tumors.
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Objective To prepare and identify monoclonal antibody ( McAb ) against the D - antigen of poliovirus type Sabin strain.
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One should note whether the antibody is polyclonal or monoclonal and also the species and isotype of the primary antibody.
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When the synthetic peptide was used as the antigen, a monoclonal antibody was obtained.
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Methods By using an uncoloured affinity-electrophoresis combined with monoclonal double antibody sandwich enzyme immunoassay.
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The data have been verified immunohistochemically using the monoclonal antibody Ki-67 to show a reduction in the labelling index.
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Also, when monoclonal antibodies were coupled to bacterial or plant toxins for e.g. Exotoxin A of pseudomonas aeruginosa or abrin from Abrus precatorious penetrates the cell membrane and inhibits protein synthesis.
Monoclonal Antibodies in Clinical Research
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Additionally, a polyclonal intracerebral inflammatory response may precede the proliferation of monoclonal malignant lymphoid cells.
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Only if that fails will they try biologics, newer treatments that include monoclonal antibodies such as infliximab (Remicade).
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Most of these analytes are measured by immunoassays using monoclonal or polyclonal antibodies.
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Briefly, 1×106 MNCs were stained with 1 µg fluorescein isothiocyanate (FITC) - or phycoerythrin (PE) - conjugated monoclonal antibodies for 20 min at
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The data have been verified immunohistochemically using the monoclonal antibody Ki-67 to show a reduction in the labelling index.
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FCI is a sensitive and specific method in diagnosis and classification of NHL as well as in detection of monoclonality.
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Objective To evaluate the implication of monoclonal antibody detection of faecal occult blood ( FOB ) in colorectal cancer.
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The hybridoma technique for the production of monoclonal antibodies represents one of the most important methodological advances in biomedicine during the 1970s.
Physiology or Medicine 1984 - Press Release
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Murine monoclonal antibodies conjugated with plasminogen activators may be valuable for targeting the therapeutic agent to thrombus.
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The plasma cell clone produces a monoclonal (M) protein that can lead to renal failure caused by light chains (Bence Jones protein) or hyperviscosity from excessive amounts of M protein in the blood.
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When they are available and a single component is of interest, two monoclonal antibodies of high avidity directed to different epitopes on an allergenic molecule are the most suitable.
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Visser GWM, Vosjan MJWD, Finn R, Boellaard R, et al. (2004) High-quality 124I-labelled monoclonal antibodies for use as PET scouting agents prior to 131I-radioimmunotherapy.
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The monoclonal antibodies used came from the yolk proteins vitellin and vitellogenin of the spined soldier bug, Podisus maculiventris, and the minute pirate bug, Orius insidiosus.
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These assays are performed by flow cytometry using several comprehensive panels of monoclonal antibodies including specific markers for lymphocytes, monocytes, and granulocytes.
Immunology Lab
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Affimed's proprietary and highly productive TandAb® technology enables the company to generate unique tetravalent, bispecific, fully human antibody formats that promise increased therapeutic potential and superior profiles compared to monoclonal antibodies.
Reuters: Press Release
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An irrelevant monoclonal antibody, J13, to human small intestinal brush border membranes served as a negative control.
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This effect was blocked by a monoclonal antibody to interleukin - 10, but not by antagonists to transforming growth factor-beta 1, prostaglandins, or beta-adrenergic agonists.
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Whether polyclonal proliferations progress to monoclonal lymphomas has not been proven.
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Monoclonal antibodies against pre-S proteins have recently become available for tissue staining.
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Some of the diagnostic materials for meningococci, and Chlamydia are monoclonals.
Monoclonal Antibodies in Clinical Research
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Moreover, it is the first to show effectiveness of a monoclonal antibody targeting a glycolipid.
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The worst part is that protein 1 is well-studied, there are parent and isogenic mutant strains lacking this gene, recombinant protein and monoclonal antibodies readily available.
Archive 2009-05-01
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Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention.
Ebookshare
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On the manufacturing side, Switzerland-based Lonza will make batches of five monoclonal antibody (MAb) candidates for Phase I and II trials and, assuming development progresses, provide additional capacity for later trials and subsequent commercialisation.
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Monoclonal antibody produced by continuous perfusion culture was recovered and purified by expended bed adsorption chromatography.
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Results indicated monoclonality in 80. 6% of DR4 tumors and 78. 6% of F1 tumors.
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The CB antibody was highly specific mouse monoclonal (clon 300) [16], [17].
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Lemon was in Memorial Hermann Southwest Hospital for nine days before a doctor concluded he had POEMS Syndrome, an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes syndrome.
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Evaluation of the bone marrow revealed a small monoclonal population of cytoplasmic kappa light chain-restricted plasma cells in an otherwise normocellular marrow.
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The reaction is detected using biotinylated phosphoserine, phosphothreonine, and phosphotyrosine monoclonal antibodies followed by streptavidin-phycoerythrin.
The Scientist
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Lonza will make batches of five monoclonal antibody (MAb) candidates for Phase I and II trials and, assuming development progresses, provide additional manufacturing capacity for later trials and commercialisation.
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Pollen analysis enables the honey producer to identify whether the honey is monoclonal or polyclonal.
