How To Use Kinase In A Sentence
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α, and immune complexes were subjected to in vitro kinase assays using exogenous ATP-γ32P and PI as substrates followed by fluorography.
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Enter AICAR, which targets a protein called adenosine monophosphate - activated protein kinase ( AMPK ).
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Conclusion: Both spinal and supraspinal neuronal Phosphoinositide 3-kinase(PI3K) pathway played important role in morphine dependent and naloxone-precipitated withdrawal response in mice.
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It appears that streptokinase and urokinase are equally effective.
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Typical CNS exam question: "The product of enterokinase reactions is: ......
Dr. Jonny Bowden: Jane Brody, Wrong on Nutrition
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Hemorrhage and resuscitation (H/R) leads to phosphorylation of mitogen-activated stress kinases, an event that is associated with organ damage.
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Objective To diagnose and treat leukemia, protein tyrosine kinase (PTK) activities were studied in human blood and myelogenic cell.
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PP2A inhibition prevents p107 dephosphorylation and FGF-induced cell cycle arrest The regulation of Rb protein family phosphorylation by cyclin / cdk kinases is fairly well understood, but much less is known about the phosphatases that dephosphorylate Rbs during the normal cell cycle or in response to exogenous signals.
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Getting Pregnant While Taking Celexa of 300 mg/kg/day corrupted to lollipops for one fibrinolysis did persoally chlorpromazine in hexokinase formation or any sappy adverse gugulipid effects.
Wii-volution
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Trypsin is non-active when it has not been in contact with enterokinase.
Charles Richet - Nobel Lecture
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(PHLPP1 and PHLPP2), phosphatases that selectively dephosphorylate the HM of Akt, resulting in decreased kinase activity
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The oligo primer was end labeled using T4 polynucleotide kinase.
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Over time, these over-excited receptors become desensitized to the effects of norepinephrine, largely due to the effects of a second molecule, beta-adrenergic receptor kinase.
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Protein tyrosine kinases play fundamental roles in signal transduction pathways.
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-- (BUSINESS WIRE) -- Apr 8, 2009 - KAI Pharmaceuticals, Inc., a privately held drug discovery and development company, today announced the Company has initiated a third Phase 2a study of KAI-1678, a first-in-class, isozyme-selective, small peptide inhibitor of the epsilon protein kinase C pathway (epsilon PKC).
Undefined
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The relevance to my analysis in The Edge of Evolution is that, like other mutations that help with malaria, these mutations, too, are ones which degrade the function of a normally very useful protein, called pyruvate kinase.
Scientists' Responses Solicited
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Those who test positive for the glucokinase mutation can usually stop treatment with no untoward consequences.
Times, Sunday Times
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Work with fruit flies, sea slugs, and mice has revealed the role of the cyclic adenosine monophosphate (cAMP) - protein kinase A (PKA) - cAMP responsive-element binding protein (CREB) signaling pathway in key forms of experience-driven synaptic plasticity.
Multiple Realizability
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Signal transduction by these systems usually involves autophosphorylation of a histidine kinase on a conserved histidine residue and subsequent transfer of the phosphoryl group to a conserved aspartate on a receiver domain.
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Objective To study the inference factors and their influence magnitude in the determination of glucose by hexokinase and oxidase method.
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To illustrate this point, consider a system containing two converting enzymes E 1 and E 2 (for instance, a protein kinase and a phosphatase) that interconvert substrates W and W *.
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Among their findings, mice heterozygous for a null mutation of the alpha-isoform of calcium / calmodulin-dependent protein kinase II show profoundly dysregulated behaviors, including a severe working memory deficit and an exaggerated infradian rhythm (cycle of increases and decreases in locomotor activity in their home cage; 2-3 weeks / cycle), which are comparable to the symptoms observed in patients with schizophrenia, bipolar disorder and other psychiatric disorders.
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We established transgenes, allowing conditional expression of the mutant kinase under control of the heat-shock promoter.
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These kinases have various substrates and have been shown to phosphorylate such diverse proteins as transcription factors, metabolic enzymes, ion pumps and cytoskeletal components.
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All the pieces needed for tyrosine kinase signaling came together in a single celled eukaryote.
Biomolecular Networks
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Early on, Meyerhof's group spent considerable effort to investigate the effects of hexokinase, which Meyerhof had discovered in 1927.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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Mortality among streptokinase-treated patients was 8.3% for those who also received intravenous heparin and 9.0% for those receiving subcutaneous heparin.
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The consequence of these mutations is a cascade phosphorylation of certain serine/threonine protein kinases.
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I then became interested in agents that could block the effects of cyclic AMP on phosphorylase kinase and phosphorylase activation.
Ferid Murad - Autobiography
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Kiyokawa N, Katagiri YU, Taguchi T, Suzuki T, et al. (2000) Globotriaosyl ceramide (CD77/Gb3) in the glycolipid-enriched membrane domain participates in B-cell receptor-mediated apoptosis by regulating lyn kinase activity in human
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In this study, we show that Pitx2 is phosphorylated by the protein kinase Akt2 and is necessary to ensure proper C2C12 myoblast proliferation and differentiation.
Naturejobs - All Jobs
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This enzyme, called protein kinase G (PKG), is turned on and activated in response to injury or inflammation.
Discovery: Chronic Pain ‘On/Off’ Switch | Impact Lab
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In the search for answers to these questions, suspicion fell most strongly on a reaction catalyzed by an enzyme called hexokinase (hek'soh-ky'nays).
The Human Brain
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This flavoprotein is a serine-threonine protein kinase able to phosphorylate its serine and threonine residues.
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And then the astounding discovery was made that a bacterial enzyme, streptokinase, could dissolve human clots.
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This activates so called protein kinases, which cause certain "key proteins" to become phosphorylated, that is phosphate molecules are added.
Physiology or Medicine for 2000 - Press Release
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Until the results of long term follow up are available the ability of our creatine kinase assay to detect Becker cases remains uncertain.
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It is therefore unsurprising that patients with pulmonary embolism treated with streptokinase and urokinase are three times more likely to show clot resolution than patients taking heparin alone.
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A DNA substrate containing a thymidine kinase gene fused to a neomycin-resistance gene was stably integrated into cells.
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These results suggest that hexokinase is a bifunctional enzyme with catalytic and sugar-sensing activities in plants.
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Other biochemical markers for oxidative damage and inflammation, such as DNA, creatine kinase also known as creatine phosphokinase, and myeloperoxidase activity, were also significantly reduced in the astaxanthin-treated exercise group.
Forever Young
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A classic example of a receptor tyrosine kinase receptor is the insulin receptor.
2008 June - Telic Thoughts
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For gene therapy based on the introduction of the herpes simplex virus thymidine kinase gene, the bystander effect depends on cell to cell contact and the presence of gap junctions.
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MethodsThe supporter paper fiber was activated with epoxy chloropropane etc. According to the influence of spacer and different ligand on absorption of kinase, process route was optimized.
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There are two osmoregulatory MAP kinase pathways in S. cerevisiae; both lead to activation of the MAP kinase Hog1, but only one pathway requires Ste11.
Scientific Blogging
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Some of the key features of nonradioactive kinase kits on the market are outlined below.
The Scientist
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Enter AICAR, which targets a protein called adenosine monophosphate - activated protein kinase ( AMPK ).
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Today the company said it is expanding its immunotherapy platform by acquiring exclusive rights to immune-modulating molecules known as FMS-like tyrosine kinase 3 ligand (Flt3L) and CD40 ligand (CD40L), from
Boston.com Most Popular
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In general, protein kinases are enzymes that phosphorylate proteins, which then become activated.
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As trypsinogen is secreted into the duodenum, it is changed into trypsin by enterokinase.
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Tyrosine kinases associated with cyclins have also been shown to be affected by vitamin K, which can lead to cell cycle arrest and cell death.
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A four-day infusion of urokinase has been an accepted treatment, and most of the patients who receive this treatment are found to have at least a 50 percent resolution of the thrombus.
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These included Viesturs Simanis, Sergio Moreno and Kathy Gould, who between them worked out that cdc2 encoded a protein kinase that was regulated during the cell cycle and was controlled by tyrosine phosphorylation.
Sir Paul Nurse - Autobiography
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Agoston H, Khan S, James CG, Gillespie JR, Serra R, et al. (2007) C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and - independent pathways.
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In another similar experiment, citicoline, alone or in combination with the thrombolytic agent urokinase, was injected into rats following occlusion of the middle cerebral artery.
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Furthermore, many patients given streptokinase produce neutralising antibodies after the first exposure, which reduces effectiveness on subsequent use.
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A problem that warrants further study derives from our observation in 1967 that instead of being in the cytosol most of the hexokinase of tumor and animal cells is associated with the outer membrane of the mitochondrial fraction26.
Irwin Rose - Autobiography
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Methods The supporter paper fiber was activated with epoxy chloropropane etc. Accordiag to the influence of spacer and different ligand on absorption of kinase, process route was optimized.
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We encourage the use of the term "pantothenate kinase – associated neurodegeneration" for the majority of patients with Hallervorden – Spatz syndrome who have proved or suspected mutations in PANK2.
Archive 2003-01-01
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Erlotinib is a small molecule tyrosine kinase inhibitor that efficiently blocks EGFR.
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High levels of intracellular calcium allow calmodulin to activate the myosin light chain kinase that facilitates muscle contraction.
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These transcription factors and kinases are primarily cytoplasmic until activated, when they translocate to the nucleus.
The Scientist
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Some of those little nasties found innocent of producing havoc in the immune system were: low ferritin concentrations and elevated uric acid and phosphokinase and cortisol levels.
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Lumbrokinase is the name of a group of highly stable fibrinolytic enzymes originally derived from the earthworm Lumbricus rubellus.
Wil's Ebay E-Store
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There are two more groups of oncogene products with phosphokinase activity; firstly tyrosine/phosphokinase which lack receptor function and is located at the inside of the cytoplasmic membrane, and secondly serine/threonine phosphokinase which is found in the cytoplasm.
Nobel Prize in Physiology or Medicine 1989 - Press Release
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This messenger in turn activates a so-called kinase, an enzyme that attaches phosphate groups to other proteins.
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For patients with acute ischemic stroke, we recommend against streptokinase ( Grade 1 A ).
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Many leukemic oncogenes form as a consequence of gene fusions or mutation that result in the activation or overexpression of a tyrosine kinase.
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AKH receptors, located on the surface of fat body cells, trigger increased synthesis of cAMP, which serves to activate phosphorylase b kinase, leading to phosphorylase activation, and the subsequent release of glucose from glycogen.
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In general, protein kinases are enzymes that phosphorylate proteins, which then become activated.
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Cellular products include myokinase, creatine phosphokinase, and myosin.
Undefined
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In addition, creatine phosphokinase (CK), CK-MB activity and C-reactive protein (CRP) were assessed.
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Activation of presynaptic cAMP-dependent protein kinase A (PKA) triggers presynaptic long-term plasticity in synapses such as cerebellar parallel fiber and hippocampal mossy fiber synapses.
Proceedings of the National Academy of Sciences current issue
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Phosphatases, acting as the "off switch," control the activation of protein kinases.
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The expression of an enzyme known as pyruvate kinase is reduced in immune cells in pregnant women compared to non-pregnant women, according to Howard R.
PhysOrg.com - latest science and technology news stories
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The ribR gene in Bacillus subtilis encodes monofunctional flavin kinase, which would convert riboflavin to FMN.
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The broad spectrum serine protease plasmin is formed following cleavage of the zymogen precursor plasminogen by host activators tissue plasminogen activator and urokinase.
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Glucose transport is rapid so that the first irreversible step, hexokinase, must determine the rate of net flux.
Irwin Rose - Autobiography
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Two of these, adenylate kinase and purine nucleoside phosphorylase, contain potential critical building blocks.
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This receptor kinase can recognize a structure on bacterial pathogens called flagellin that makes the bacteria motile.
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The most widely accepted and significant leukemogenic mechanism attributed to the fusion protein involves the constitutive stimulation of tyrosine kinase.
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The concentrations of urokinase type plasminogen activator in the duodenum resemble the quantities found in normal stomach tissue biopsy specimens.
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Center's (Eyverkinasa), which is a recombinant streptokinase used in case of a heart attack; (Evermin), which is an epidermic growth factor; and Interferon.
Castro, Colombian Businessmen Review Trade
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In a mouse study, Dickek and his team transplanted bone marrow containing macrophages that overproduce a protein-digesting enzyme known as urokinase into aged, atherosclerotic mice.
Innovations-report
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The stronger stimulus will give rise to increased levels of the messenger molecule cAMP and thereby protein kinase A.
Physiology or Medicine for 2000 - Press Release
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Blood tests measure the cardiac enzymes creatine phosphokinase or CPK, special subfractions of CPK, and troponin that are typically elevated in the blood several hours after a heart attack.
The 10 Best Questions™ for Recovering from a Heart Attack
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Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention.
Ebookshare
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Guts: All the pieces needed for tyrosine kinase signaling came together in a single celled eukaryote.
Biomolecular Networks
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The third type of hyperinsulinism, which is extremely rare, is glucokinase hyperinsulinism.
Diazoxide
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It has recently been reported that the release of mitochondrial hexokinase and some associated proteins may play a role in the onset of the apoptosis cascade27.
Irwin Rose - Autobiography
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Puckishly pleadingly is a free weight loss plan enterokinase on the sexy innocence of croatian or punctually on the garbed plowed needlepoint of the fool, as the devourer has to marquess a nodular faraday.
Rational Review
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Recent antitumor research has been focused on tyrosine kinase growth factor receptors.
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Motivated by our previous findings that Stx can mediate its own uptake and affect signaling, we set out to investigate if Stx, although binding to a glycolipid, was able to increase the formation of endocytic clathrin coat structures at the plasma membrane and if such increase in clathrin coats might be mediated by signaling through the Syk kinase.
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When I got the results of his lab work, I was surprised to see an elevated muscle enzyme level creatine phosphokinase or CPK.
If you’re taking a supplement, tell your doctor
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Concentrations of serum creatine kinase, transaminases, urea, and creatinine may be raised, and bicarbonate may be reduced.
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Of Meyerhof's many achievements, perhaps the most important is his proof that, in isolated but otherwise intact frog muscle, the lactic acid formed is reconverted to carbohydrate in the presence of oxygen, and his preparation of a KC1 extract of muscle which could carry out all the steps of glycolysis with added glycogen and hexose-diphosphate in the presence of hexokinase derived from yeast.
Otto Meyerhof - Biography
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Subjects - Those families whose son had a positive screening test. Main outcome measures - Creatine kinase activity.
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In general, cyclins are proteins that regulate the cell cycle by combining with cyclin dependent kinases to form an enzymatic complex.
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Furthermore, many patients given streptokinase produce neutralising antibodies after the first exposure, which reduces effectiveness on subsequent use.
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Tissue plasminogen activator and, to a lesser degree, urokinase are serine proteases which convert plasminogen to plasmin.
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The disorders can be treated with uridine and/or cytidine, which leads to increased UMP production via the action of nucleoside kinases.
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This phosphoprotein is regulated post-translationally by reversible phosphorylation catalysed by a protein kinase and a microcystin-sensitive serine/threonine protein phosphatase.
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Although muscle damage is usually associated with elevated levels of an enzyme called creatine phosphokinase, the CMAJ research shows that's not always the case.
Signs of the Times
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McLoughlin M, McKeon F (1993) Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase.
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They report that a single switch in a splice isoform of the glycolytic enzyme pyruvate kinase is necessary for the shift in cellular metabolism to aerobic glycolysis and that this promotes tumorigenesis.
Carbohydrates are addictive | The Blog of Michael R. Eades, M.D.
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PINOID kinase regulates root gravitropism through modulation of PIN2-dependent basipetal auxin transport in Arabidopsis thaliana.
SpaceRef Top Stories
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Active enzyme systems not consistently resolved for this species were: ACO, adenylate kinase, diaphorase, EST, G - 6 - PDH, GSR, IDH, and PGI.
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Until the results of long term follow up are available the ability of our creatine kinase assay to detect Becker cases remains uncertain.
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It reduced levels of glycolytic enzymes such as hexokinase, phosphoglucoisomerase and aldolase levels, which are increased in hepatoma-bearing rats, and increased levels of gluconeogenic enzymes such as glucose. 6-phosphatase and fructose-I
Find Me A Cure
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Urokinase bound to its receptor maintained fibrinolytic activity over 24 hours in the rabbits.
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However, the activity of hexokinase in muscle is so high that any free glucose is immediately phosphorylated and enters the glycolytic pathway.
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We also show that pathologic hypertonicity levels, as occurring in plasma of patients and animal models of osmoregulatory disorders, inhibited the induction of cyclins and aurora B kinase in response to T cell receptor stimulation in fresh NFAT5
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Thus any condition that affects the rate of glucose utilization of red cells must do so by either having an effect on G6P or on the activity of the hexokinase itself.
Irwin Rose - Autobiography
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Five studies used streptokinase, two used urokinase, and four used tissue plasminogen activator.
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In fact, getting selective kinase inhibitors was the hard part - looking back, had we but known, we all could have probably skipped that step and gone right to the blunderbusses.
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After meals, when postprandial blood glucose levels are high, liver glucokinase is significantly active, which causes the liver preferentially to trap and to store circulating glucose.
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The steady-state ITC method has been used to determine the enzyme kinetics parameters of several enzymes, including H. pylori urease, E. coli GroEL chaperonin, heparinase I, yeast hexokinase, HIV protease, pyruvate carboxylase, and dinucleoside polyphosphate hydrolase.
GEN News Highlights
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Objective To investigate the feasibility and efficacy of high dose urokinase thrombolysis for treating lower limb deep venous thrombosis (DVT) after inferior vena caval (IVC) filter placement.
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In these assays, proprietary fluorescent phosphopeptide tracers compete with nonfluorescent phosphopeptides generated during kinase reactions for binding to phosphospecific antibodies.
The Scientist
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Five studies used streptokinase, two used urokinase, and four used tissue plasminogen activator.
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The fact that cyclic AMP mediates its effects via stimulation of a protein kinase activating the enzyme phosphorylase explains how a hormone signal can lead to quick mobilization of sugar.
Physiology or Medicine 1992 - Press Release
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LPS tolerance may also be induced by mycoplasmal lipopeptides that impair the MyD88-depending signaling by inhibiting LPS-mediated activation of IL-1 receptor-associated kinase (IRAK1)
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In several instances an erroneously regulated protein kinase activity is responsible.
Physiology or Medicine 1992 - Press Release
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We also show that pathologic hypertonicity levels, as occurring in plasma of patients and animal models of osmoregulatory disorders, inhibited the induction of cyclins and aurora B kinase in response to T cell receptor stimulation in fresh NFAT5
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Protein kinases turn on other enzymes by a chemical reaction called phosphorylation that adds phosphate tags to proteins.
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UW researchers learned that, inside some advanced plaques, macrophages that overproduce a protein-digesting enzyme known as urokinase into aged, atherosclerotic mice.
THE MEDICAL NEWS
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As a result of these actions, a nationwide shortage of urokinase became apparent, and a replacement for urokinase needed to be identified.
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The interconversion of the bifunctional enzyme is catalyzed by cAMP-dependent protein kinase, which in turn is regulated by circulating peptide hormones.
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This was eventually solved with the finding of the cyclic AMP-dependent protein kinase by one of my postdoctoral fellows, Donal A. Walsh.
Edwin G. Krebs - Autobiography
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Protein kinases are enzymes that participate in signal transduction processes and, thus, in the control of cell growth.
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His (BUN) blood, urea, nitrogen levels were at 100 (healthy is about 20) and his creatine phosphokinase (CPK) or phospho-creatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. levels were 2.1
Wil's Ebay E-Store
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In this manner, the glycogen catabolizing phosphorylase is regulated by two enzymes working in opposing directions in a reversible process, one kinase and one phosphatase.
Physiology or Medicine 1992 - Press Release
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These messengers travel into the cell and activate a protein kinase, which starts to bind phosphate groups to other proteins, in this way altering their function.
The Nobel Prize in Physiology or Medicine 2000 - Presentation Speech
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Moolten FL (1986) Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.
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This conversion is catalyzed by the ATP requiring enzyme, pyridoxal kinase.
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If there is no Krebs cycle, no metabolism and no more ATP to phosphorylate peptides in kinase activity etc, then that organism is simply dead — and it is in equilibrium, or is on a monotonic course to equilibrium as it decays or is consumed by other organisms.
A Dark, Misleading Force
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For instance, platelets might deliver an enzyme called urokinase to selectively disintegrate blood clots.
THE MEDICAL NEWS
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Corticosteroid treatment suppressed other proangiogenic factors in hemangioma-derived stem cells, including urokinase plasminogen activator receptor, interleukin-6, monocyte chemoattractant protein 1, and matrix metalloproteinase 1.
Medlogs - Recent stories
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Statins were found to be safe, with minimal or no significant increase in liver function test abnormalities or elevation of creatine kinase levels.
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Researchers have used this approach to identify protease and kinase substrates, protein: protein interactions, and protein: nucleic acid interactions.
The Scientist
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Munster and colleagues address three important aspects of our article and set up questions concerning the accuracy of our data, especially in view of the nebulization of urokinase.
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Amano M, Nagata K, Inagaki N, Nakamura H, et al. (1998) Roles of Rho-associated kinase in cytokinesis; mutations in Rho-associated kinase phosphorylation sites impair cytokinetic segregation of glial filaments.
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I find no evidence of liver disease, and I perform a simple blood test called creatine phosphokinase CPK, or CK.
DR. SANJIV CHOPRA’S LIVER BOOK
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The STK11 gene has the ability to produce an enzyme called "serine/threonine kinase 11" that has several important functions:
Peutz-Jeghers Syndrome (PJS)
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The first is a magnetic nanoparticle designed to target a molecule known as urokinase plasminogen activator receptor.
PhysOrg.com - latest science and technology news stories
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Research being conducted in the space shuttle is seeking to grow urokinase crystals in space for subsequent X-ray analysis in Earth-based laboratories.
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Not always necessarily at the same time, but at least to be able to look at protein kinase activity, redox state, gene transcription, protein degradation, localization of DNAs and RNAs by slightly more indirect means, which if you use GFP and RFP to label a protein that in turn binds specifically to your favourite nucleic acid, and the list goes on and on.
Roger Y. Tsien - Interview
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Pfizer also noticed crizotinib had effects on another enzyme implicated in cancer cell growth, known as anaplastic lymphoma kinase, or ALK.
New Pfizer Drug Shrinks Some Lung-Cancer Tumors
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Ishizaki T, Watanabe N, Uehata M, Kranenburg O, et al. (1998) Molecular dissection of the Rho-associated protein kinase (p160ROCK) - regulated neurite remodeling in neuroblastoma N1E-115 cells.
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Purcell PC, Smith AM, Halford NG (1998) Antisense expression of a sucrose non-fermenting-1-related protein kinase sequence in potato results in decreased expression of sucrose synthase in tubers and loss of sucrose-inducibility of sucrose synthase transcripts in leaves.
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Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors.
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This flavoprotein is a serine-threonine protein kinase able to phosphorylate its serine and threonine residues.
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The systematic review included information on three different thrombolytic agents: streptokinase, urokinase, and recombinant tissue plasminogen activator, but direct comparison of different thrombolytic drugs was not possible.
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A protein kinase moves a phosphate group (P) from ATP (ADP (P)) to the protein.
Physiology or Medicine 1992 - Press Release
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We report that there is substantial although not complete control of glycolytic oscillations in hexose transport, so that phosphofructokinase cannot be the oscillophore.
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Furthermore, many patients given streptokinase produce neutralising antibodies after the first exposure, which reduces effectiveness on subsequent use.
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The authors of the study published in Science noted a number of interesting things - a preponderance of genes encoding protein kinases, evidence for substantial horizontal gene flow from bacteria and archaebacteria, and a streamlined core gene expression machinery transcription and RNA processing.
The Panda's Thumb: Research News Archives
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Thus, it acts in a complementary mechanism to GKRP, which also regulates glucokinase protein expression and compartmentation .
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Some RGV genes and their functions have been identified, including deoxyuridine triphosphatase (dUTPase), thymidine kinase (TK),
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Subsequently, our lab used the pulse/chase method to study hexokinase in the steady state by comparing the 14C-G6P formed in an acid quench with that formed in a high substrate chase with time of quenching,
Irwin Rose - Autobiography
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Protein kinase C was partially purified from rat liver by homogenization, ammonium sulfate fractionation and DEAE-cellulose chromatography.
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Kinase activity is then quantified in western blot assays using phosphospecific antibodies.
The Scientist
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Some kinases only phosphorylate "downstream" of other phosphosites.
Prediction of phospho-proteins from sequence
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Mice that were given a chemical that blocks the function of an enzyme called Fyn kinase burned more fatty acids and expended more energy, which made them leaner.
Medlogs - Recent stories
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Vander Heiden is now studying one of the key enzymes involved in cancer cells 'metabolic pathways, known as pyruvate kinase M2, with an eye toward developing drugs that could alter its activity and effectively starve cancer cells of the materials they need to grow and reproduce.
PhysOrg.com - latest science and technology news stories
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Tissue plasminogen activator and, to a lesser degree, urokinase are serine proteases which convert plasminogen to plasmin.
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This reaction is catalyzed by the enzyme hexokinase.
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To do that, they use an enzyme called pyruvate kinase M2 allows the sugar breakdown process to be used even though it is normally only activated in the absence of oxygen.
Winnipeg Sun
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↑ Wang YF, Hatton GI (2007) Interaction of extracellular signal-regulated protein kinase 1 / 2 with actin cytoskeleton in supraoptic oxytocin neurons and astrocytes: role in burst firing.
Citizendium, the Citizens' Compendium - Recent changes [en]
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At 39,472 bp, the annotated genome revealed a closer relationship to coliphage T3 than T7 with Kvp1 containing homologs to T3 early proteins S-adenosyl-L-methionine hydrolase (0.3) and protein kinase (0.7).
BioMed Central - Latest articles
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If you the sleeplessly cartwheel as it is, you viscacha, in my retinal, an numbfish to miscreant the observingly sheldrake foraminifera steinbeck. tensity ellipsoidal, disobediently kubrick, from cold aegilops ballroom to hoist, to streptokinase, to dextrality with jabberwocky fibrin and guardant cliquishness.
Rational Review
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According to the study authors, the gene variant may affect the activity of an enzyme in the brain, called pyridoxal kinase (PDXK).
Medlogs - Recent stories
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In contrast, when athletes stop training, the activities of their muscles' glycolytic enzymes, such as phosphorylase and phosphofructokinase, change little, if at all, for at least four weeks.
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ANTIDIABETES Improving the secretion of insulin by repairing damaged pancreatic beta-cells; promoting the absorption of glucose in the liver; inhibiting the release of glucose from the liver by increasing hexokinase activity; reducing glucose-6-phosphatase activity
Forever Young
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This messenger in turn activates a so-called kinase, an enzyme that attaches phosphate groups to other proteins.
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PTK787 is the most promising VEGF receptor- tyrosine kinase inhibitor in pipeline because of its potency in tumor inhibition and oral bioavailability.
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I find no evidence of liver disease, and I perform a simple blood test called creatine phosphokinase CPK, or CK.
DR. SANJIV CHOPRA’S LIVER BOOK
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The precipitants with protein A-Sepharose were divided into three equal parts, one for the kinase assay at 25°, one for the kinase assay at 37°, and one for the Western blotting.
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When H - 8, a protein kinase G inhibitor, was injected 90 minutes after PGE2, however, the hyperalgesic duration was reduced.
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Myopathy was defined by muscle weakness, elevated creatine kinase (CK) levels, myopathic EMG findings, muscle edema on MRI, and/or features of myopathy on muscle biopsy.
Science Blog
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The second operon encodes a phosphatase, an epimerase and the thiamine pyrophosphokinase (TPK).
Elites TV
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It boils down to this: When you give mice a chemical that blocks the function of the enzyme known as Fyn kinase, they almost immediately begin burning more fat.
Gaea Times (by Simple Thoughts) Breaking News and incisive views 24/7
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Phosphorylase kinase phosphorylates phosphorylase, which is activated
MedPoster 1992
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It is going to lead to increases in the appearance, of proteins, such as creatine kinase in the bloodstream.
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The concentrations of urokinase type plasminogen activator in the duodenum resemble the quantities found in normal stomach tissue biopsy specimens.
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Objective To investigate the association between the G/A variant at position-30 of the glucokinase gene promoter in Yunnan Chinese subjects and type 2 diabetes.
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The expression of an enzyme known as pyruvate kinase is reduced in immune cells in pregnant women compared to non-pregnant women, according to Dr. Howard R.
Gaea Times (by Simple Thoughts) Breaking News and incisive views 24/7
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PTK787 is the most promising VEGF receptor- tyrosine kinase inhibitor in pipeline because of its potency in tumor inhibition and oral bioavailability.
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Players showed high levels of an enzyme called creatine kinase, which is a sign of vigorous exercise.
KSDK.com NBC-St. Louis Education
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Urokinase also activates a substance in blood vessels called plasminogen and turns it into plasmin, another protein-destroying enzyme.
Innovations-report
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The Competitive Intelligence Report c-MET/HGF Inhibitors as of February 2010 provides a competitor analysis in the development pipeline of novel emerging inhibitors of c-MET receptor tyrosine kinase (RTK) and its ligand hepatocyte growth factor
The Earth Times Online Newspaper
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The effective dose of urokinase, as calculated with respect to the loss of activity caused by ultrasonic nebulization, has been given in both the print version of the manuscript and the online repository.
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By 1950, the list of products included deoxyribonuclease, erythrogenic toxins, fibrinolysin, haemolysin, hyaluronidase, leucocidin, lipoproteinase, proteinase, ribonuclease, streptodornase, and streptokinase.
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In general, if there are no contraindications, streptokinase is preferred by some because of its lower cost.
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Summary of Background Data. The stress-activated mitogen-activated protein kinase pathways including ASK1 transmitted apoptosis signals after acute spinal cord injury.
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It is therefore conceivable that if this Tyr were to be nitrated, it may switch the kinase from the active to the inactive state by increasing its hydrophilicity.
PLoS ONE Alerts: New Articles
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We did pulse/chase experiments in which the labeled glucose came from hexokinase in the crystalline state either alone or together with ADP31.
Irwin Rose - Autobiography
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This reaction is catalyzed by the enzyme hexokinase.
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At the center of the cell-cycle control system is a protein called cyclin-dependent-kinase
PhysOrg.com - latest science and technology news stories
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Kinases are specialized transferases that regulate metabolism by transferring phosphate from ATP to other molecules.
