How To Use Glycolysis In A Sentence
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Meyerhof was convinced that an active form of hexosemonophosphate was an intermediate in glycolysis and associated with the formation of pyruvate.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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Conclusion It is suggested that the increased synthesis of GLUT1 and GLUT3 induced by HI could accelerate the utilization of glucose in the brain and adapt to the requirement of anaerobic glycolysis.
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Consequently, these mutant cells rely exclusively on glycolysis for their energy requirements and require exogenous pyruvate and pyrimidines for growth.
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Of Meyerhof's many achievements, perhaps the most important is his proof that, in isolated but otherwise intact frog muscle, the lactic acid formed is reconverted to carbohydrate in the presence of oxygen, and his preparation of a KC1 extract of muscle which could carry out all the steps of glycolysis with added glycogen and hexose-diphosphate in the presence of hexokinase derived from yeast.
Otto Meyerhof - Biography
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Although ATP plays a critical role in glycolysis, it is only one actor among many in a very large production.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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This picture only gradually became clear as Meyerhof and others simultaneously worked out the cyclical process of glycolysis and the reversibility of certain reactions.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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They report that a single switch in a splice isoform of the glycolytic enzyme pyruvate kinase is necessary for the shift in cellular metabolism to aerobic glycolysis and that this promotes tumorigenesis.
Carbohydrates are addictive | The Blog of Michael R. Eades, M.D.
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Reactions leading to esterification were particularly difficult to identify, because these processes take place at different levels of glycolysis.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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Consequently, these mutant cells rely exclusively on glycolysis for their energy requirements and require exogenous pyruvate and pyrimidines for growth.
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Since the pools of glycolysis intermediates are very low in plant cells in the absence of oxygen, it seems unlikely that MeG synthesis started at the level of hexoses (or trioses) phosphate.
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The cells depend on glycolysis for their main energy requirements and also require supplementation with uridine and pyruvate for growth.
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Answering such questions was a challenge because most of the components involved in glycolysis were typified by a very transient existence, making them difficult to isolate, much less analyze, test and then place in proper sequence.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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Enzymes primarily involved in glycolysis and in the Krebs cycle showed only a small rise in activity (PFP, PFK and malate dehydrogenase).
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The muscle-specific isoform (type M, PGAM2) of phosphoglycerate mutase (PGAM) is a housekeeping enzyme which catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate in the glycolysis process to release energy
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The unravelling of its structure and bioenergetic role in glycolysis clearly stands out as a major scientific accomplishment.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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Many of these proteins are enzymes that participate in glycolysis and alcoholic fermentation or in other aspects of carbohydrate metabolism.
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Embden isolated adenosine monophosphate (AMP) in 1928, Meyerhof and others began a serious search for other phosphates involved in glycolysis and yeast fermentation.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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One involves the uptake of sugars that are broken down in the cytoplasm into a molecule called lactate by a process called glycolysis, which quickly yields a small amount of ATP, the enzyme that provides cellular energy.
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The oxidation of one molecule of glucose via glycolysis and cell respiration releases enough energy to form 38 ATP molecules.
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Consequently, these mutant cells rely exclusively on glycolysis for their energy requirements and require exogenous pyruvate and pyrimidines for growth.
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The networks related to cellular development and connective tissue disorder showed that enzymes such as phosphoglycerate 12 mutase (glycolysis), muscle proteins such as myosin heavy chain 4 (Actin cytoskeleton signaling), nebulin-related anchoring protein (Actin binding protein) were significantly down regulated by TWEAK (
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Working out the importance of the phosphorylated compounds in muscle, for example, greatly stimulated the understanding of energy transformations in glycolysis and changed thinking about how the pathway might be constructed.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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A key adaptation allowing a continued high level of glycolysis in crucian carp is the production and excretion of ethanol as the glycolytic end-product, thereby avoiding lactate self-poisoning.
Evolution versus "Intelligent Design" - The Panda's Thumb
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The unravelling of its structure and bioenergetic role in glycolysis clearly stands out as a major scientific accomplishment.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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Other studies multiple have demonstrated that the intermediate products in glycolysis drive the production of MG and show that when the total time subjects are in the glycolytic state is lessened, so is the production of MG.
The low-fat diet cascade | The Blog of Michael R. Eades, M.D.
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Among these anaerobic proteins are enzymes involved in glycolysis and related processes.
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Meyerhof's greatest achievement was his ability to clarify both the starring and supporting roles of the many molecules involved in glycolysis and then place them in proper sequence of the metabolic script.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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Meyerhof and Hill's pioneering thermodynamic studies had been the basis for the conclusion that the cycle of lactic acid formation and oxidation were the key events in glycolysis.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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The understanding of the individual reactions in glycolysis grew geometrically.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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There is clear evidence of metabolite channeling in the urea cycle, the citrate cycle, glycolysis, and other metabolic pathways.
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Lactate concentrations in whole blood are extremely unstable because of the rapid production and release of lactate by erythrocytes due to glycolysis.
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Parnas soon postulated a phosphate cycle, whereby the use of one ATP for phosphorylation is balanced by regeneration of ATP during subsequent steps in glycolysis.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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oxidative glycolysis
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In addition to spawning Meyerhof's first doubts about the centrality of lactic acid in glycolysis, the discovery encouraged him to begin measurements of the amount of energy released by the splitting of the bonds of creatine phosphate and other phosphate derivatives.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
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One of most important advances of the decade involved painstaking work that helped demonstrate that the formation of esters from carbohydrates is indeed an intermediate reaction in glycolysis.
Otto Meyerhof and the Physiology Institute: the Birth of Modern Biochemistry
