How To Use Extracellular In A Sentence

The "extrinsic" pathway involves transmembrane, extracellular receptor-dependent activation of caspase-8 (and possibly -10). The Scientist
The extracellular signaling of hormones, light, and odorants is facilitated by a large family of G-protein-coupled receptors.
In in vitro preparations of partially purified enzymes, the functional distinction between intracellular and extracellular calcium is lost.
MAb 4C5, while not affecting secretion of the inactive MMPs, inhibits their activation by disrupting their interaction extracellularly with both isoforms of HSP90. BioMed Central - Latest articles
Extracellular osmolal concentration is approximately twice the sodium concentration.

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Calcium currents were isolated by replacing extracellular sodium with TEA and adding tetrodotoxin and other K + channel blockers.
More than 90 per cent of tissue can be such extracellular material. Times, Sunday Times
These animals are thought to survive only if ice is confined to their body cavity and other extracellular spaces.
A thin layer of extracellular matrix (perimysium) separating fiber groups within the muscle appears in cross-section.
Portions of both a and b form the extracellular ligand binding domains. The Scientist
In in vitro preparations of partially purified enzymes, the functional distinction between intracellular and extracellular calcium is lost.
Some procedures supply immediate gratification, such as zapping away brown spots or erasing lines, and some can provide long-term antiaging results by growing more collagen and invigorating the extracellular matrix. Simple Skin Beauty
Treh-1 is a cytosolic enzyme involved in the hydrolysis of endogenous trehalose, while Treh-2 is an extracellular enzyme proposed to have a role in the assimilation of exogenous trehalose as a carbon source PLoS ONE Alerts: New Articles
The potential involvement of extracellular histones in atherogenesis may be envisaged through several routes. PLoS ONE Alerts: New Articles
The extracellular matrix is a complex mixture containing proteins such as fibronectin and collagen that provide structural support to cells and traction for cell movement. Science Blog - Science news straight from the source
Integrin is the molecule that connects the outside of the cells to the extracellular matrix.
In the present study, no association was found between the use of extracellular preservation fluid and early gas exchange.
Similarly, homeostatic mechanisms that regulate the extracellular environment may be affected by characteristics of the cell surface.
The Anion Hypothesis There are certain organic anions present in the axoplasm of a neuron but absent from the extracellular ﬂ uid. Recently Uploaded Slideshows
In some areas, particularly those close to the surface of the tumors, the eosinophilic extracellular material resembled fibrinoid necrosis and showed associated areas of organization consistent with typical granulation tissue.
Journal of Cell Biology reveals that an extracellular matrix protein called laminin shapes both sides of the junction to ensure they fit together. Health News from Medical News Today
After resuspension in 1 mM chloride extracellular medium, cells were isolated by gentle trituration.
Fluid inside your cells is called intracellular fluid and the fluid outside your cells is called extracellular fluid. The Most Complete Food Counter, 2nd Edition
On the extracellular side of the membrane, a small extracellular domain is composed of short loops between various transmembrane helices and contains the binding site for ouabain.
Fragments of metachromatic chondromyxoid extracellular material contained cells that were reminiscent of chondrocytes.
Fluid inside your cells is called intracellular fluid and the fluid outside your cells is called extracellular fluid. The Most Complete Food Counter, 2nd Edition
On the inner surface of the cell layer, a basal lamina (an organized layer of extracellular matrix) is laid down.
One possible, straightforward interpretation of these results would be that the current rising phase is related to electrogenic chloride binding from the extracellular side induced by GABA to the transporter.
When present, the annelid peritoneum either rests directly on the muscle cells or is separated from them by a layer of extracellular matrix.
At the junction of the flowing blood and extracellular space, the endothelium is a dynamic organ that modulates local hemostasis, cell trafficking, and microcirculatory blood flow.
Additionally, there will be an increased renal excretion of potassium causing a decrease of potassium in the extracellular fluid. 258.
During seizures, there was a sustained increase in extracellular glutamate to potentially neurotoxic concentrations in the epileptogenic hippocampus.
Integrins are an ancient group of animal adhesion receptors that attach cells to the extracellular matrix.
In at least two, widely divergent systems, electron-dense extracellular tubules have been observed surrounding developing spores during sporogony.
That powder is a substance made from pig bladders called extracellular matrix. March « 2008 « Gerry Canavan
Uroisolate PU7, was found to elicit the maximum virulence factors elaborating extracellular enzymes, protease, elastase, phospholipase C, haemolysin and pyochelin.
The cell wall and extracellular material are often only crudely preserved in this process, and the internal cytoplasm may degrade and be destroyed.
Strategies that allow plants to survive freezing temperatures have been placed into two major categories: those plants that exhibit deep supercooling characteristics and those that exhibit extracellular freezing.
They are stored within the basal membrane or extracellular matric and released in an active form to stimulate tissue repair and healing.
One-quarter of this extracellular fluid is contained within blood vessels as the plasma space.
This absence of effects is in line with the data from Fig.2, and confirmed that the intracellular and extracellular concentrations of Cl were truly equilibrated.
It is possible that depolarization forces internal polyamines through the pore, where they might accumulate in an unstirred extracellular space, blocking the channel during the measurement of inward conductance.
The capillary grows by degradation of the extracellular matrix and proliferation of cells at the tip of the sprout.
Chemokines bind heparin and other glycosaminoglycans of the extracellular matrix of cells, which helps establish and maintain a chemokine gradient. The Scientist
It can be readily seen that sodium is the principal extracellular cation and that chloride and bicarbonate are the principal extracellular anions.
It can be readily seen that sodium is the principal extracellular cation and that chloride and bicarbonate are the principal extracellular anions.
Moreover, for a number of cell types and extracellular matrix molecules, cell speed exhibits a biphasic behavior with respect to surface ligand density.
Objective To establish an expression system of human II CD74 extracellular fragment by insect baculovirus vector expression system in insect cells.
At the junction of the flowing blood and extracellular space, the endothelium is a dynamic organ that modulates local hemostasis, cell trafficking, and microcirculatory blood flow.
Translation takes place in embryonic mesoblasts and larval fat-body cells and is deposited extracellularly in basement membranes surrounding skeletal and visceral muscles.
Chemokines bind heparin and other glycosaminoglycans of the extracellular matrix of cells, which helps establish and maintain a chemokine gradient. The Scientist
Extracellular osmolal concentration is approximately twice the sodium concentration.
We are currently investigating if, similar to hNSCs, also T-IhNSCs can be induced to generate catecholaminergic cells by exposure to specific extracellular cues PLoS ONE Alerts: New Articles
In our body, the cells in each of these organs sit in a fibrous extracellular matrix. Times, Sunday Times
The mesoderm also provides the mesenchyme (by sinking of cells from its epithelium into the extracellular matrix) from which organ development becomes possible.
Liver fibrosis and cirrhosis, characterized by the excessive production and decreased degradation of abnormal extracellular matrix, are a major cause of morbidity and mortality in biliary atresia. Basic Science Liver Disease Research
These toxins can remain inside algal cells (intracellular toxins), or they may be released into the surrounding water (extracellular toxins) during active algal growth or when algal cells lyse. Inorganic nitrogen pollution in aquatic ecosystems~ causes and consequences
The extracellular medium was redissolved in deionized water and extracellular polymers were precipitated by adding ethanol to reach a final concentration of 80%.
The viral RNA challenge falls short because the genomes of such viruses do decay in extracellular environments. Another Protozoan and Front-Loading
The Sec24CD dependent COPII vesicles, thus, carry cuticle components as diverse as for example the chitin synthase producing the bulk of the procuticle, factors of the extracellular melanisation pathway, and the yet unknown lipid-handling enzymes of the envelope and epicuticle. PLoS ONE Alerts: New Articles
The short answer is: an extracellular matrix composed of collagen, proteoglycans, adhesive glycoproteins, and integrin.
Ligand-competitive binding of antibodies was measured by Notch1 extracellular domain (ECD) displacement in a dissociation-enhanced time resolved fluorometric assay (DELFIA). PLoS ONE Alerts: New Articles
the body normally has about 15 quarts of extracellular fluid
Certain cells, such as fibroblasts - cells responsible for producing extracellular matrix in wound healing and tissue remodelling - will migrate along the tracks.
However, filopodial protrusions would be more efficient for crawling through extracellular matrix and on surfaces of other cells.
As the electrolytes shift out of the cells, fluid shifts into the cells so that the tonicity matches that of the extracellular space.
Dentin is a complex mixture of extracellular matrix proteins, of which 90 percent is collagen. The Scientist
The mesoderm also provides the mesenchyme (by sinking of cells from its epithelium into the extracellular matrix) from which organ development becomes possible.
After peripheral nerve injuries, Schwann cells play an indispensable role in promoting regeneration by elaborating basement membrane containing extracellular matrix proteins, such as laminin PLoS ONE Alerts: New Articles
Direct-acting pressors have their action extracellularly at postsynaptic receptors. 4 The evaluation of liver function at initial presentation andfour tosix weeks following recovery is recommended, although the incidence of hepatotoxicity following acute overdose is rare. 5 Caution should be exercised in the use of sedative/hypnotics for CNS excitation because of synergistic depressant effects during overdose. Monamine Oxidase Inhibitors
Both are presumed to be consequences of cell death, and the subsequent leakage of cell contents into the extracellular space.
Histologic studies have revealed altered fiber structure, increased vascularity, and changes in the extracellular matrix in patients with chronically painful Achilles tendons.
Multimeric molecules may also be organized into supramolecular structures presenting discrete adhesion domains within the extracellular environment.
In addition to the spindle cells, abundant strongly eosinophilic, stellate, extracellular matrix deposits composed of crystalline fibers were seen.
Instead, water distribution will be determined by the relative allocation of solute to the extracellular and intracellular spaces.
The "extrinsic" pathway involves transmembrane, extracellular receptor-dependent activation of caspase-8 (and possibly -10). The Scientist
The capillary grows by degradation of the extracellular matrix and proliferation of cells at the tip of the sprout.
In healthy persons, sodium loading increases extracellular fluid volume and EABV, resulting in prompt natriuresis and restoration of normal volumes.
The environment in this case is the extracellular matrix, or ECM, as indicated by one of its components, fibronectin. The Panda's Thumb: Steve Matheson Archives
There are reports of exposure to fungal elicitors leading to extracellular alkalization in plant cell cultures.
These so-called amyloid deposits accumulate extracellularly in various organs.
Full-thickness articular cartilage core specimens were cut and stained with hematoxylin and eosin and safranin-O to analyze extracellular matrix morphology, as described.
Barnase is an extracellular ribonuclease produced by Bacillus amyloliquefaciens.
extracellular fluid
Instead, water distribution will be determined by the relative allocation of solute to the extracellular and intracellular spaces.
The natural biological organism derived materials included mainly collagen, fibrin gelatum, hyaluronic acid, chitin and natural extracellular matrix after acellular disposal, etc.
↑ Wang YF, Hatton GI (2007) Interaction of extracellular signal-regulated protein kinase 1 / 2 with actin cytoskeleton in supraoptic oxytocin neurons and astrocytes: role in burst firing. Citizendium, the Citizens' Compendium - Recent changes [en]
Cells are prestressed networks of tension-bearing microfilaments that are coupled to compression-resistant microtubules and extracellular matrix molecules.
Indeed, all the genes encoding enzymes required for de novo AMP biosynthesis are repressed at the transcriptional level by the presence of extracellular purines (adenine or hypoxanthine).
However, this difference disappears upon addition of heavy metal chelators in the extracellular bath.
To formally explore this possibility, we construct a compartmental model of a substratum-adherent cell, and focus on how the extracellular space parameters affect fluxes of water and of bilayer after a shrinking perturbation.
Cancer brings about new blood vessel formation (angiogenesis), exposing collagen through turnover of the extracellular matrix. The Scientist
The decreased secretion of aldosterone will affect body electrolyte balance and extracellular fluid volume.
This latter explanation fits with ionic current data that have shown that C-type inactivation is accelerated when the extracellular cation concentration is changed or univalent metal cations are removed altogether.
Wu YP, Siao CJ, Lu W, Sung TC, Frohman MA, et al. (2000) The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. PLoS ONE Alerts: New Articles
In recent years, Anfinsen has devoted himself primarily to comprehensive investigations of an extracellular nuclease of Christian Anfinsen - Biography
Additionally, the blood-brain barrier in ICH is disrupted and allows molecules, such as glucose, to extravasate from the intravascular to the extracellular space. Recently Uploaded Slideshows
Extracellular mucin positivity is not significant.
And how about hardened arteries and weakened ligaments caused by so-called cross-linking extracellular proteins? Times, Sunday Times
The protein, called extracellular matrix protein ECM may act like a natural sunscreen to prevent sun damage and prevent the skin from aging. Gene Discovery May Stop Skin Aging | Impact Lab
Ecsod can be detected in the arterial intima, media, bronchiolar epithelium, alveolar epithelium, and extracellular matrix of human neonatal lung.
This extracellular material is located between the connective tissues and is called the extracellular matrix. CreationWiki - Recent changes [en]
Invitro, high extracellular calcium concentrations inhibit the proliferation of human colonic epithelial cells and several colonic cancer cell lines.
Cysteine in the extracellular space is mostly oxidized to cystine.
Cathepsin D is another enzyme that degrades the extracellular matrix and the basement membrane. It plays a kay role in tumor invasion and metastasis.
Large continuous masses of eosinophils were situated within the extracellular matrix, beneath the bronchiolar smooth muscle layer.
The xanthan gum is the extracellular polysaccharide secreted by xanthomonas campestris from wild rape. It can be produced by fermentation with starch or glucose as the carbon source.
There are reports of exposure to fungal elicitors leading to extracellular alkalization in plant cell cultures.
Lysyl oxidase catalyses the cross-linking of fibrillar molecule of type I collagen into mature insoluble extracellular matrix.
The principal of pathological changes of DN included glomerulus hypertrophy, glomerulus extracellular matrix accumulating, basement membrane thickening and glomerulosclerosis.
Direct-acting pressors have their action extracellularly at postsynaptic receptors. 4 The evaluation of liver function at initial presentation andfour tosix weeks following recovery is recommended, although the incidence of hepatotoxicity following acute overdose is rare. 5 Caution should be exercised in the use of sedative/hypnotics for CNS excitation because of synergistic depressant effects during overdose. Monamine Oxidase Inhibitors
The integrity of the endothelial cell layer is also controlled by the tethering of the cells to the extracellular matrix through integrins.
These enzymes are essential for the chemical processes of life, both inside cells and in the extracellular fluids.
When researchers administered a protein enzyme called extracellular signal-related kinase or ERK, it appeared to suppress intestinal turmorigenesis in the mice, causing cancer proteins to degrade more rapidly and increasing the survival time of the mice. Daily News & Analysis
Full-thickness articular cartilage core specimens were cut and stained with hematoxylin and eosin and safranin-O to analyze extracellular matrix morphology, as described.
To account for the influence of cytoplasmic and extracellular water, a computational membrane with its embedded channel is sandwiched between two large water boxes, generally the bulk of the computational system.
This extracellular material located between the connective tissues and called extracellular matrix. CreationWiki - Recent changes [en]

How To Use Extracellular In A Sentence

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