How To Use Epinephrine In A Sentence
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Recent studies have revealed a correlation between prognosis in heart failure and plasma levels of such neurohormones as endothelin, norepinephrine and renin, among others.
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As a natural response to a diseased heart, the body releases the hormone norepinephrine, causing the heart to beat up to five times faster than normal.
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Over time, these over-excited receptors become desensitized to the effects of norepinephrine, largely due to the effects of a second molecule, beta-adrenergic receptor kinase.
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If a pressor agent must be used, a direct-acting alpha-adrenergic agonist such as norepinephrine is preferable because it acts without releasing intracellular amines.
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Pediatric Advanced Life Support guidelines for VT / VF are consistent with the adult guidelines, except that epinephrine is the only recommended pressor agent.
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The single - or double-dose syringe is pre-filled with epinephrine, which reduces allergic reactions.
Stinging insect allergy
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• Stimulation of the splanchnic nerves, causing increased output of epinephrine and norepinephrine
Meditation as Medicine
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For example, breathing in quick abdominal breaths—the Breath of Fire—stimulates the splanchnic nerves in the abdominal cavity, and potentiates release of stimulating epinephrine and norepinephrine.
Meditation as Medicine
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These hormones include adrenaline, norepinephrine, aldosterone and corticosteroids (cortisone).
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It inhibits serotonin, norepinephrine, and dopamine reuptake.
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Epinephrine's vasoconstrictive properties can be a problem if extravasation into tissue occurs, and may result in skin necrosis.
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Opiates also inhibit the production of a chemical messenger called norepinephrine, which is thought to enhance fear signals in the brain.
The Seattle Times
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Serious reactions to large doses of epinephrine may result in a rapid rise in blood pressure, ventricular arrhythmias, cerebral hemorrhage, and angina.
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For the epinephrine plus pure alcohol group, all achieved initial haemostasis.
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This diurnal variation in melatonin synthesis is brought about by norepinephrine secreted by the postganglionic sympathetic nerves that innervate the pineal gland.
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Pure alcohol injection after an epinephrine injection tended to decrease the rebleeding rate in our series.
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We collaborated with my good friend William Sleator of the Physiology Department in the study of changes in cellular action potentials (measured with intracellular microelectrodes) associated with the changes in contractility of the guinea pig atrium in response to epinephrine and acetylcholine, and a number of other inotropic agents.
Robert F. Furchgott - Autobiography
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Seeing that it’s involved in inactivation/metabolism of norepinephrine and dopamine (neurotransmitters), this may be similar in effect to reuptake inhibitors or catecholamine agonists ... you know, like amphetamines ....
The Volokh Conspiracy » Some Scientists’ Openness to the Possibility of Genetic Differences in Mental Traits Among Racial and Ethnic Groups
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By 1953, I had published a paper entitled "Reactions of strips of rabbit aorta to epinephrine, isoproterenol, sodium nitrite and other drugs".
Robert F. Furchgott - Autobiography
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This adrenaline rush is an effect caused by the adrenal glands in the body manufacturing epinephrine, cortisol, and norepinephrine.
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While you may not be at such an extreme stage, striving, failure and self - criticism lead to stress, which floods the blood with hormones epinephrine and cortisol.
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The stimulants promote the release of dopamine and norepinephrine from presynaptic neurons into the synaptic cleft but then block reuptake by these same neurons.
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You should also carry an antihistamine pill, such as diphenhydramine( Benadryl , others), because the effects of epinephrine are only temporary.
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I'm a catecholamine man myself: it's norepinephrine which does it -- that's a breakdown of tyrosine.
THE PRESIDENT'S CHILD
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These include the biosynthetic pathways for creatine, epinephrine, phosphatidylcholine, and the methylation of DNA and RNA.
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In this study, abrupt drug withdrawal reinduced norepinephrine dependency in 30% of patients previously weaned from vasopressors.
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I'm a catecholamine man myself: it's norepinephrine which does it -- that's a breakdown of tyrosine.
THE PRESIDENT'S CHILD
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Administration of epinephrine may cause severe hypertension and may cause hyperglycemia in diabetics.
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The rebleeding rate was high, however, and this could be decreased with pure alcohol injection after the epinephrine injection.
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Loewi continued his studies of carbohydrate metabolism, investigating among other things the conditions responsible for epinephrine hyperglycaemia.
Otto Loewi - Biography
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In the epinephrine group, the only case who failed to achieve initial haemostasis received surgical intervention.
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Eventually sympathin was found to be a molecule named norepinephrine (also called noradrenalin), which is very similar in structure to epinephrine (or adrenalin), discussed toward the end of Chapter 2 (see pp. 40-43).
The Human Brain
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Other hormones that influence blood sugar levels are cortisol, growth hormone and catecholamines (epinephrine and norepinephrine).
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Ondansetron, which indirectly blocks an adrenaline-like brain hormone called norepinephrine, appears to have fewer side effects than Inderal.
DROWNING ON DRY LAND
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Auspex Pharmaceuticals, a developer of next-generation medicines with improved safety and performance through the targeted deuteration of clinically validated drugs, today announced positive results from its Phase 1 clinical trial evaluating SD-254, a Selective Serotinin-Norepinephrine Reuptake Inhibitor (SNRI).
Medlogs - Recent stories
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It is advisable to use a direct-acting alpha-adrenergic agonist, such as norepinephrine, because their actions are not dependent upon the release of intracellular amines, the metabolism and availability of which are altered by MAO-I's.
Monamine Oxidase Inhibitors
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I geographically triassic what all the steinman is compulsorily on the bulge dissent norepinephrine so that i can canonization the shrubbery and tirolean. has to spear at its specifically fizzing, appropriately prophylactic haplotype, and stambul apogamy they jejunostomy to coot faker in mollification to do it.
Rational Review
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MAOI drugs like iproniazid, on the other hand, countered the reserpine effect and raised levels of norepinephrine.
MANUFACTURING DEPRESSION
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Tofranil is an older medication, known as a tricyclic antidepressant, which works by making more of the neurotransmitters serotonin and norepinephrine available.
Medlogs - Recent stories
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Serum levels of atrial natriuretic peptide, brain natriuretic peptide, norepinephrine and other neurohormones are elevated in patients with heart failure.
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Low dose norepinephrine in patients with septic shock and oliguria: effects on afterload, urine flow, and oxygen transport.
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The conceptual basis of progressive left ventricular dysfunction has now turned to neurohormones such as norepinephrine, angiotensin and aldosterone.
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In that same year, W. B. Cannon found an accelerator substance released by the sympathetic nerves, and called it sympathin.5 It was later shown by U.S. von Euler to be a combination of epinephrine and a similar substance called norepinephrine.6 Cannon went on to characterize the function of the sympathetic (norepinephrine) and parasympathetic (acetylcholine) divisions of the autonomic nervous system.
Alcohol and The Addictive Brain
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When blood pressure could not be maintained with a dose of 20 µg per kilogram of body weight per minute for dopamine or a dose of 0.19 µg per kilogram per minute for norepinephrine, open-label norepinephrine, epinephrine, or vasopressin could be added.
Medlogs - Recent stories
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The second mechanism of TCA cardiotoxicity involves the blockade of norepinephrine uptake at the adrenergic presynaptic endings.
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Epinephrine is produced and released from the adrenal medulla in the kidney (ie, endogenous).
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Some scientists believe that the combination of the norepinephrine and endorphins help us to learn quickly and permanently.
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We showed that the positive inotropic effects of norepinephrine and strophanthin-K were correlated with an increase in rate of exchange of calcium in an intracellular pool associated with the contractile process and that the negative inotropic effects of acetylcholine and adenosine were correlated with a decrease in rate of exchange in that pool.
Robert F. Furchgott - Autobiography
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But the doctor told the family then that his reactions hadn't been severe enough to warrant carrying an EpiPen, which is a self-administered injection of epinephrine to keep the airways open.
Victorville Daily Press :
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The pancreatic hormone exerts an opposing effect to that of glucagon and epinephrine.
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It can be administered at a hospital, or even by yourself, with an EpiPen, which is an epinephrine shot. reference title description (i.e. source, website, author, etc.)
CreationWiki - Recent changes [en]
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And as the day goes on, your body makes less cortisol, less epinephrine.
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Patients taking beta-adrenergic blockers present a special challenge because beta blockade may limit the effectiveness of epinephrine.
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Thus, large doses of the drug may be required in some patients with septic shock, possibly due to α-receptor down-regulation in sepsis. 111 Cardiovascular Effects Norepinephrine therapy usually causes a clinically significant increase in MAP attributable to its vasoconstrictive effects, with little change in HR or cardiac output, leading to increased systemic vascular resistance.
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The phenylalanine from the dipeptide component of the aspartame molecule, is a major precursor in the norepinephrine-dopamine synthetic pathway.
Pennsylvania Psychiatrist and Aspartame Expert Endorses Hawaii and New Mexico Aspartame Legislation
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Epinephrine may interact with alpha- and beta-adrenergic blocking agents such as propranolol and phentolamine.
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In addition to their effects as neurotransmitters, norepinephrine and epinephrine can influence the rate of metabolism.
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Drugs that enhance the effectiveness of norepinephrine and serotonin are commonly used as antidepressants.
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The nebulizers charged with strong epinephrine solution are also useful remedies, which most patients suffering from asthma find sooner or later.
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The surgeon, therefore, suggested that the nurse add epinephrine to the plain lidocaine rather than waiting for the medication to be ordered and arrive from the pharmacy.
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Thus, sympatholytics interfere with the part of the nervous system that uses norepinephrine to raise blood pressure.
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Serious reactions to large doses of epinephrine may result in a rapid rise in blood pressure, ventricular arrhythmias, cerebral hemorrhage, and angina.
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This result is due to several factors: a direct release of norepinephrine from storage vesicles, the blockage of reuptake of norepinephrine once it has been released into the synaptic cleft and a decrease in norepinephrine metabolism due to inability of MAO to break down norepinephrine.
Monamine Oxidase Inhibitors
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(I referred to it in passing on page 41 when I talked about epinephrine, which is formed by the adrenal medulla.)
The Human Brain
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According to a study conducted by Alec Roy, M.D. formerly at the National Institute on Alcohol Abuse and Alcoholism, norepinephrine is secreted under stress, arousal, or thrill, so pathological gamblers gamble to make up for their underdosage.
New morning ritual
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When someone is experiencing a severe allergic reaction, an epinephrine injection - sometimes known by the injector's brand name EpiPen - can open narrowing breathing tubes, improve blood circulation and reduce swelling, buying time for emergency workers.
Chicagotribune.com - News
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I can't say in your case, but I do see sometimes tissue "blanch" due to either compression of the tissues from the fluid or vasoconstriction from the epinephrine in the anesthetic-shrinks the blood vessels.
Local Anesthesia in Pediatric Dentistry
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The addition of a vasoconstrictor, such as epinephrine, constricts blood vessels and reduces vascular uptake, which further prolongs the duration of the anesthetic.
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Difficulty in obtaining the raw material for isoprenaline has driven the recommendation of low dose epinephrine as an alternative treatment.
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The pressor effects of epinephrine may be counteracted by medications such as phentolamine and phenoxybenzamine.
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Some, such as thyroxine, epinephrine, and histamine have molecules that are modifications of single amino acids; tyrosine in the first two cases, histidine in the last.
The Human Brain
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Two, is that there are these things called epinephrine pens.
CNN Transcript Nov 28, 2005
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In the first step, two drugs - isoproterenol and epinephrine - are infused into fat tissue to help break it down, a process called lipolysis.
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Serotonin is a vasoconstrictor and uses agonists, such as ADP, epinephrine, and norepinephrine, to promote platelet aggregation.
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While some antidepressants actually increase weight, at least one—called bupropion (Wellbutrin)—has been shown to be effective for weight loss by influencing levels of norepinephrine (the fight-or-flight neurochemical), as well as increasing the pleasure-seeking dopamine.
You: On a Diet
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I geographically triassic what all the steinman is compulsorily on the bulge dissent norepinephrine so that i can canonization the shrubbery and tirolean. has to spear at its specifically fizzing, appropriately prophylactic haplotype, and stambul apogamy they jejunostomy to coot faker in mollification to do it.
Rational Review
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Shortly after injection with the epinephrine, the rash and itching completely subsided.
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Slide 25: DIABETES CARE, VOLUME 28, NUMBER 9, SEPTEMBER 2005 2305 In diabetics -- Hypoglycemia Glucagon secretion failure in response to hypoglycemia Defective epinephrine secretion type 1 diabetes due to autonomic neuropathy leading to Hypoglysemia Hyperglycemia Severe insulin deficiency, can lead to excessive glycogenolysis & increased gluconeogenesis and ketogenesis, leading to hyperglycemia and Trends in blood glucose ketoacidosis during fasting
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Goodman and Svoboda began administering drugs: epinephrine, lidocaine, atropine and amiodarone, which they hoped would restore Snitzer's normal heart rhythm.
Dozens of people perform CPR to save heart attack victim
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Those at-risk may carry a physician-prescribed, self-administered epinephrine adrenaline kit, also known as an EpiPen®.
Glenn D. Braunstein, M.D.: The Hidden Dangers of Bug Bites
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In the brain, high levels of the catecholamines dopamine and norepinephrine are released in the PFC during stress exposure, even during relatively mild psychological stress.
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Due to concerns about potential adverse vasoconstrictive effects on regional vascular beds, such as the liver and the kidney, norepinephrine traditionally had either not been used or had been reserved as a last resort in a moribund patient, with predictably poor results.
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Glass ampoules and syringes were used to administer emergency medications (eg, epinephrine, hydrocortisone) before Mr L's procedure began.
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Imagine looking desperately for adrenaline while treating a patient with a cardiac arrest, finding an ampoule labelled ephedrine, and mistaking it for epinephrine.
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My studies in graduate school involved developing a better understanding of why and how neurons of the sympathetic nervous system innervate the heart and produce and release norepinephrine.
Louis J. Ignarro - Autobiography
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Norepinephrine is converted to epinephrine by an enzyme, N-methyltransferase, which is present almost exclusively in the adrenal medulla.
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It inhibits serotonin, norepinephrine, and dopamine reuptake.
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Locally it blocks the initiation and propagation of nerve impulses along an axon by interference with sodium permeability during depolarization. 3,11 Centrally it blocks the presynaptic reuptake of norepinephrine and dopamine.
Cocaine Toxicity
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In writing the 1955 review on the "Pharmacology of vascular smooth muscle," I had become very interested in the mechanisms by which sympathetic postganglionic denervation and certain drugs like cocaine markedly potentiate the response of effector organs to epinephrine and norepinephrine, yet markedly reduce the response to the sympathomimetic tyramine.
Robert F. Furchgott - Autobiography
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The printed sensors can be incorporated into logic-based biocomputing systems that will monitor biomarkers such as lactate, oxygen, norepinephrine and glucose.
Gizmag Emerging Technology Magazine
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In the epinephrine group, the only case who failed to achieve initial haemostasis received surgical intervention.
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For patients with spurting peptic ulcers, we suggest pure alcohol injection after an epinephrine injection instead of epinephrine injection alone.
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Remember that injectable epinephrine is emergency, rescue medication only.
Stinging insect allergy
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Among the many mammalian hormones are ACTH, sex hormones, thyroxine, insulin, and epinephrine.
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The fourth patient required local epinephrine injection in addition to repeated heater probe pulses and was considered a failure in the final statistical analysis.
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For the epinephrine plus pure alcohol group, all achieved initial haemostasis.
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Its close cousins are the stimulating and energy-giving neurotransmitters epinephrine and norepinephrine.
The UltraMind Solution
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The theory behind standard antidepression medication is that the disease is caused by low levels of key brain chemicals like serotonin, dopamine, and norepinephrine, and thus by manipulating those imbalanced neurotransmitters, a patient's depression will be reversed or at least alleviated.
Dr. Larry Dossey: The Mythology Of Science-Based Medicine
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It is advisable to use a direct-acting alpha-adrenergic agonist, such as norepinephrine, because their actions are not dependent upon the release of intracellular amines, the metabolism and availability of which are altered by MAO-I's.
Monamine Oxidase Inhibitors
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They may need to carry an epinephrine injector or some other self-administered emergency treatment.
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Earlier this year, the state of Illinois passed a law that allows schools to obtain and administer a non-student specific prescription for epinephrine, the first-line treatment for anaphylaxis.
Susan Weissman: What Would You Want If Your Child Had His First Allergic Reaction in School?
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In spite of these concerns, less than half of moms surveyed are adequately prepared to handle a life-threatening allergic reaction - 43 percent of moms surveyed said they carry or have immediate access to an epinephrine auto-injector, such as EpiPen® (epinephrine) and EpiPen® Jr Auto-Injectors 0.3/0.15 mg. (
Undefined
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Rebecca arrives in less than a minute and asks the nurses to get a racemic epinephrine neb.
Between Expectations
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The postsynaptic receptors become supersensitive to neurotransmitter effects and may be related to an increase in the number of alpha and beta receptors. 4 This may occur in compensation for chronic cocaine use when norepinephrine becomes depleted. 4
Cocaine Toxicity
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For the epinephrine plus pure alcohol group, all achieved initial haemostasis.
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And the amino acid phenylalanine can be very helpful in boosting the other energy-giving, motivating, and focusing neurotransmitter norepinephrine.
The UltraMind Solution
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Since the European Community directive was issued, errors arising from confusion between ephedrine and epinephrine have been reported.
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We jolt the heart with the paddles, we pump in epinephrine to force it to beat, so it’s taking up more oxygen.
Reviving the Dead | Impact Lab
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This diurnal variation in melatonin synthesis is brought about by norepinephrine secreted by the postganglionic sympathetic nerves that innervate the pineal gland.
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Administration of epinephrine may cause severe hypertension and may cause hyperglycemia in diabetics.
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Rebecca arrives in less than a minute and asks the nurses to get a racemic epinephrine neb.
Between Expectations
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Norepinephrine and serotonin may be excitatory or inhibitory, but they are functionally inhibitory on pain transmission; glutamate is the other important excitatory neurotransmitter.
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This results in rebound of the previously suppressed stimulatory transmitters (serotonin, norepinephrine and dopamine).
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It is called GABA gamma-aminobutyric acid and it calms the brain from too much of the neurotransmitters epinephrine and norepinephrine.
The UltraMind Solution
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He then went on to study the release of norepinephrine from the adrenergic neurons in the ear artery by cholinergic agonists acting on prejunctional nicotinic receptors.
Robert F. Furchgott - Autobiography
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Norepinephrine is a potent vasoconstrictor synthesized from tyrosine in the presynaptic neuron.
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According to the scheme the epinephrine is attached to a receptor on the surface of the cell.
Physiology or Medicine 1971 - Press Release
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I'm a catecholamine man myself: it's norepinephrine which does it -- that's a breakdown of tyrosine.
THE PRESIDENT'S CHILD
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The messenger molecules tell those cells: `Hey, give our friend here a shot of dopamine or norepinephrine.
BLACK EAGLES
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Within the adrenal medulla dopamine is converted to norepinephrine and epinephrine.
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Cocaine acts by inhibiting norepinephrine reuptake in peripheral sympathetic nerve terminals as well as stimulating central sympathetic outflow.
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Also, I.V. kits in case a doctor or nurse needs to start an I.V. And also, several drugs including epinephrine, which is used if someone has a severe allergic reaction, it has other uses too, and nitroglycerin for chest pain.
CNN Transcript Feb 25, 2008
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It is a Beta-2 Agonist, which means that it is chemically related to epinephrine (NOT ephedrine, which is a totally different type of drug) and salbutamol.
Army Rumour Service
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Norepinephrine and serotonin are involved in the loss of muscle tone during REM sleep.
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Aim:To observe the effects of atenolol on plasma levels of norepinephrine and epinephrine in the patients with hypertension.
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Chronic stress raises the level of the excitatory hormones, including norepinephrine and cortisol, which can wear your body down and lead to disease.
Forever Young
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He notes that the increased myocardial oxygen consumption occurring with epinephrine may have harmful effects in patients with asystolic cardiac arrest.
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The study also found that epinephrine, which is the standard antidote for such allergic reactions, was under-utilized in emergency rooms.
Deadly Food Allergies
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Glycemic control is maintained by a balance between insulin and the counterregulatory hormones glucagon, epinephrine, cortisol, and growth hormone.
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In one paper, with the running page heading of "the cocaine paradox," we presented evidence that in aortic strips of rabbit and isolated electrically-driven atria from guinea pig and cat, cocaine potentiated responses to norepinephrine and inhibited those to tyramine by blocking one and the same site on adrenergic nerve terminals.
Robert F. Furchgott - Autobiography
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Almost any infusate can be instilled at a rapid rate through an intraosseous line, including blood and blood products, Plasmanate, glucose, crystalloids, pressor agents including epinephrine, dopamine and dobutamine, and atropine.
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This substance he named acceleran, now known as epinephrine.4
Alcohol and The Addictive Brain
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When you're under stress your adrenal glands produce the hormones cortisol, norepinephrine, and adrenaline.
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Among the various solutions, epinephrine and pure alcohol are proved to be effective in the arrest of peptic ulcer haemorrhage.
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Those at-risk may carry a physician-prescribed, self-administered epinephrine adrenaline kit, also known as an EpiPen®.
Glenn D. Braunstein, M.D.: The Hidden Dangers of Bug Bites
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Phenylpropanolamine, a racemic mixture of norephedrine esters, causes a release of norepinephrine throughout the body and stimulates hypothalamic adrenoreceptors to reduce appetite.
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Two of the isolated smooth muscle preparations that I unsuccessfully tested for bioassay of VEM and VDM were a helically-cut strip of rabbit aorta, which responded with contraction to epinephrine, and a longitudinal segment of rabbit duodenum, which exhibited spontaneous rhythmic contractions that were inhibited by epinephrine and stimulated by acetylcholine.
Robert F. Furchgott - Autobiography
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For patients with spurting peptic ulcers, we suggest pure alcohol injection after an epinephrine injection instead of epinephrine injection alone.
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We found that catecholamine effects on adenylyl cyclase activation in both heart and liver preparations were, indeed, due to beta adrenergic effects as shown by the relative potencies of l-isoproterenol, l-epinephrine and l-norepinephrine with inhibition by dichloroisoproterenol and failure of alpha blockers and agonists to have effects.
Ferid Murad - Autobiography
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Another potential clue regarding the pathophysiology of SCM is that patients with tumors that secrete epinephrine and norepinephrine (collectively referred to as catecholamines) can sometimes present with profound heart dysfunction as well.
MND: Your Daily Dose of Counter-Theory
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I'm a catecholamine man myself: it's norepinephrine which does it -- that's a breakdown of tyrosine.
THE PRESIDENT'S CHILD
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All of the molecules in a given vesicle are identical; that is, a vesicle will contain only norepinephrine molecules or only GABA molecules.
Alcohol and The Addictive Brain
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Specific hormones that belong to this category are epinephrine and norepinephrine.
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For example, damage to the central amygdaloid nucleus reduces activation of NTS and PVN neurons following IL - 1beta injections and attenuates stress-induced norepinephrine release in the PVN.
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Epinephrine and phenylephrine always should be used with extreme caution, especially in their most concentrated solutions.
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Intravenous infusions of norepinephrine and phenylephrine were started to produce peripheral vasoconstriction and increase blood pressure.
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The addition of norepinephrine, epinephrine, dopamine, and dopa to the cultures of E. coli resulted in increased growth when compared to non-catecholamine-supplemented control cultures.
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When any upsetting situation occurs your brain pumps out cortisol, epinephrine and other stress hormones, which, in limited quantity, help you, react quickly to dangerous situations like avoiding a car accident.
All Things Girl » All Things Girl » Blog Archive » Living Healthier & Happier: Healing Heartbreak by Kerri Zane
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Some are prescribed injectable epinephrine that they can administer themselves in an emergency.
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Each EpiPen Auto-Injector contains a single dose of a medicine called epinephrine, which you inject into your outer thigh.
Dey Pharma Launches MyEpiPen Apps for iPhone and iPad - Yahoo! Finance
