How To Use Dedifferentiate In A Sentence
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The ability to dedifferentiate stem cells (the article uses the term retrodifferentiation) would be incredibly valuable just for leukemia treatment.
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At the most extreme dedifferentiated state embryonic stem cells are so dedifferentiated that they have the ability to become all more specialized cell types.
The Speculist: Good News on Stem Cells
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In other words, a skin cell can dedifferentiate into a stem cell, then regenerate into a muscle cell or another completely different type of cell.
Cells That Go Back in Time
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Objective To study the cell biological characteristics of dedifferentiated condyle chondrocytes.
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But in the new research, scientists added genes to mature cells that turned back their cellular clocks, or dedifferentiated them, restoring them to an immature, unprogrammed state.
Skin-Cell to Stem-Cell Hack Is Like 'Turning Lead Into Gold'
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For example, they found that the proliferating cells dedifferentiated, meaning they temporarily lost the characteristics of mature heart muscle cells and reverted to a more fetal type of proliferating cell.
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IF we figure out how to turn adult stem cells – what GW is supporting here – into embryonic stem cells, that is cells that are dedifferentiated to the point that they can recreate any human organ then the Prez is supporting the creation of ARTIFICIAL blstocysts that can be allowed to develop into EMBRYOES.
Think Progress » Bush on Stem Cell Veto: ‘These Boys and Girls Are Not Spare Parts’
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the hebephrenic--the most severely dedifferentiated of all schizophrenic patients
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We found no regulation in proliferation data from dedifferentiated or embryonic cells, and we observed a dual control in proliferation data from normal mouse bone marrow cells, and from normal human fibroblasts (however, the latter was a short series).
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Liposarcoma represents a unique model insofar as some well-differentiated liposarcomas progress to non-lipogenic, so-called 'dedifferentiated,' forms.
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To study the genetic changes in dedifferentiated liposarcomas, paired well-differentiated and dedifferentiated components of 29 tumors were analyzed separately by array-based comparative genomic hybridization.
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Lefebvre V, Peeters-Joris C, Vaes G. Modulation by interleukin 1 and tumor necrosis factor alpha of production of collagenase, tissue inhibitor of metalloproteinases and collagen types in differentiated and dedifferentiated articular chondrocytes.
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By manipulating niche signals, they could make the stem cells differentiate, then dedifferentiate again.
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Instead an adult stem cell would be forced to ‘dedifferentiate’, or revert to its more embryonic pluripotent state.
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Sprouting venous endothelial cells dedifferentiate as they migrate over and invade the myocardium.
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The search for compounds to differentiate and dedifferentiate (specialize and despecialize) stem cells is accelerating due to advances in biotechnology for growing and screening cells.
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Sure enough, Pajcini and Pomerantz found that blocking the expression of both Rb and ARF allowed individual myocytes isolated from mouse muscle to dedifferentiate and begin dividing.
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A third approach is to use one's own specialized cells and dedifferentiate them.
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The virus carries dedifferentiate and then gain the ability to differentiate into any type of cell in the body and to indefinitely propagate itself.
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The observed maturation phenomena are generally not observed in dedifferentiated HCC.
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In contrast, dedifferentiated liver cells and undifferentiated embryonic cells displayed no coordination at all, consistent with their undetermined fate
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A Japanese team at Kyoto University has discovered how to reprogram skin cells so that they “dedifferentiate” into the equivalent of an embryonic stem cell.
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