How To Use Cytotoxicity In A Sentence
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Cytotoxicity of conjugates may be influenced by many factors, including drug loading, side-chain hydrophobicity and net charge, which may ultimately affect singlet oxygen generation.
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All the three proteoglycans stimulated mice thymocyte and splenocyte proliferation and elevated cell cytotoxicity.
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The initial photooxidative injury triggers a number of responses, including direct cytotoxicity within the tumor microenvironment.
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In vitro, these peptides inhibited cytotoxicity and differentiation of cytotoxic T cells.
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Determine the dispersant concentration that induced cytotoxicity in multiple cell lines and derive an aggregate measure of cytotoxicity that could be use to rank order the chemicals and to compare with in vivo toxicity data obtained in aquatic test species.
Georgianne Nienaber: Does EPA Test for Endocrine Disruptors in Corexit Tell Us Anything?
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The composite did not exhibit cytotoxicity in the filter diffusion tests.
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Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic and semiallogeneic system.
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Objective To investigate the cytotoxicity of alcohol on hepatic and neuronic cells of rat and.
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Likewise, the suppression of the cellular immune response can be determined using well known in vitro analyses, e.g., proliferation and cytotoxicity assays or characterization of activation phenotypes of peripheral blood lymphocytes by, e.g., flow cytometric analysis.
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Because bioreductive drugs are activated to form highly effective cytotoxins under hypoxic conditions, they can be used to inactivate hypoxic tumor cells that are refractory to the direct cytotoxicity of hypericin-PDT.
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Witte et al. determined that subtoxic concentrations of membrane-damaging compounds enhanced the cytotoxicity of hydrophilic xenobiotics.
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ANTITUMOR Immune enhancement; activating macrophages, T cells, and NK cells; increasing TNF-α production; inducing cancer cell apoptosis and cytotoxicity
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IgG2a isotype antibody is known to be more effective than other isotypes in clearing virus infection via multiple mechanisms including complement activation, stimulation of antibody-dependent cellular cytotoxicity and clearance of opsonized virus by macrophages
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Another key finding was that intervention patients showed higher levels of three key markers of immune system function after 12 months: natural killer cell cytotoxicity and Con A and PHA blastogenesis.
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Qualitatively, no difference was observed in the cytotoxicity of unheated, heated and ultra filtered culture supernatants of isolates.
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Optics and optical instruments - Contact lenses - Determination of cytotoxicity of contact lens material - Part 1: agar testinhibition test.
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We currently have an opportunity for a cellular immunologist preferably with 4 to 6 years industrial/biotech experience and who is able to perform immunological assays (flow cytometry such as intracellular cytokine staining, assays,, ELISPOT, cytotoxicity assays, Th1/Th2 cytokine response assays, cell culture etc).
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For example, often a chemical is tested with both human and animal cells to study its ability to produce cytotoxicity, mutations, and DNA damage.
Risk assessment of chemical substances
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The 10-year study began with an EPA grant to develop mammalian cell lines that would be used specifically to analyze the ability of these compounds to kill cells, or cytotoxicity, and the ability of these emerging disinfection by-products to cause genomic DNA damage.
Disinfectants Used To Purify Water Create Toxic By-Products | Impact Lab
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Natural cytotoxicity, assumed to be an important defense mechanism in viral, neoplastic, and parasitic diseases, was also reduced.
Effects of changes in ultraviolet radiation in the Arctic
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A fractionated extract of Astragalus membranaceus potentiates lymphokine-activated killer cell cytotoxicity generated by low-dose recombinant interleukin-2.
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Because bioreductive drugs are activated to form highly effective cytotoxins under hypoxic conditions, they can be used to inactivate hypoxic tumor cells that are refractory to the direct cytotoxicity of hypericin-PDT.
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In this study, the cytotoxicity of various sub-fractions of dichloromethane extract isolated from the leaves of S. crispus was determined and the anticancer activity of one of the bioactive sub-fractions, SC/D-F9, was further analysed in breast and prostate cancer cell lines.
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IgG2a isotype antibody is known to be more effective than other isotypes in clearing virus infection via multiple mechanisms including complement activation, stimulation of antibody-dependent cellular cytotoxicity and clearance of opsonized virus by macrophages
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These findings are similar to those in obese rats, which have reduced NK cell cytotoxicity which is restored upon weight loss
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This notion is also supported by the observation that substitution of salubrinal with subtoxic concentrations of the phosphatase inhibitor cantharidin induced a comparable increase in PSI-mediated cytotoxicity, whereas the PP2B / calcineurin inhibitor cypermethrin proved to be ineffective.
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We attributed the reduced cytotoxicity at higher repetition rates to the contribution of the oxygen-independent mechanism.
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T cells identify antigens, and the antigen-sensitised T cells produce cytokines and other soluble factors which mediate the hypersensitivity reaction, or else they develop cytotoxicity.
The Different Types of Dairy Allergy
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Cytotoxicity of GCV on cell cultures was determined using Cell Proliferation Kit I (MTT) (Roche, Mississauga, ON) according to the manufacturer's instructions. pAlb-vTK was digested with BstXI and HindIII to yield a 5134 bp minigene containing the murine Alb p/e with the downstream vTK coding region which was microinjected into fertilized oocytes prior to their transfer into the oviducts of pseudopregnant FVB/N mice using standard procedures
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Objective To investigate the potential influence of zinc deficiency and excessiveness on the differentiation and cytotoxicity to mice embryo limb bud cells.
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None of the sterols tested at this level induced cytotoxicity as measured by lactic dehydrogenase release.
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The Authors suggested that the absorption of anandamide by PMX might abolish the diverse negative effects of anandamide such as hypotension, immunosuppression, and cytotoxicity.
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It has been suggested that sequestration of bile acids by intracellular bile acid binding proteins may also protect cells from bile acid cytotoxicity.
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Thus it appears that PHP-mediated cytotoxicity proceeds through both membrane and mitochondrial photosensitization.
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As for safety, most drugs caused the usual signs of cytotoxicity, including neutropenia, thrombocytopenia, fever, infections, and gastrointestinal toxicity.
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Using the membrane permeabilising saponin digitonin, we measured digitonin applications of different concentrations in cytotoxicity assays over 18 h alone to normalise the data of the combination treatment of EGCG and digitonin against the toxic effect the adjuvant already determines alone.
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