How To Use Cytotoxic In A Sentence
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URL van Baalen CA, Guillon C, van Baalen M, Verschuren EJ, Boers PHM, et al. (2002) Impact of antigen expression kinetics on the effectiveness of HIV-specific cytotoxic T lymphocytes.
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Slide 13: MHC molecules and T cell function Class I MHC molecules Most nucleated cells of the body Infected / cancerous cells display parts of foreign antigens on surfaces Recognized by cytotoxic T cells Class II MHC molecules Dendritic cells, macrophages, B cells (APCs) display phagocytized antigen fragments on surfaces Recognized by helper T cells T cells that have receptors for self - molecules are destroyed self - tolerance
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T cells identify antigens, and the antigen-sensitised T cells produce cytokines and other soluble factors which mediate the hypersensitivity reaction, or else they develop cytotoxicity.
The Different Types of Dairy Allergy
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In addition to expediting the compounding process and enhancing patient safety, RIVA has notably improved work and safety conditions for hospital staff, reducing their exposure to a multitude of drug compounds - namely cytotoxic drugs.
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CD8+ cells — also called cytotoxic T-lymphocytes (CTLs) — matter because, among other actions, they kill cells that become infected with HIV.
AIDS: The Elusive Vaccine
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Cytotoxic antibiotics, such as doxorubicin, stick to DNA causing it to become tangled and preventing the cell from dividing.
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Natural cytotoxicity, assumed to be an important defense mechanism in viral, neoplastic, and parasitic diseases, was also reduced.
Effects of changes in ultraviolet radiation in the Arctic
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A fractionated extract of Astragalus membranaceus potentiates lymphokine-activated killer cell cytotoxicity generated by low-dose recombinant interleukin-2.
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The nasal tampon, drawing experience from the advantages of synthetic sponge is chemically pure (vinylic polymer), biocompatible, anallergic and non cytotoxic
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The values were averaged over triplicates (each containing 200 to 300 parasites) and normalised to the cytotoxicty assay of 40 µg/ml to 70 µg/ml digitonin without EGCG application measured over
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Because bioreductive drugs are activated to form highly effective cytotoxins under hypoxic conditions, they can be used to inactivate hypoxic tumor cells that are refractory to the direct cytotoxicity of hypericin-PDT.
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Aim To investigate the cytotoxic activity of HDAC inhibitor Trichostatin A (TSA)combined with anticancer drugs targeting DNA on T24 bladder cancer cell line.
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This reaction results in the production of oxygen radicals, which are cytotoxic to the tumor cells.
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A competitive pathway also converts 6-MP to its cytotoxic 6-thioguanine nucleotides (6-TGNs) that are associated with bone marrow suppression (leukopenia, neutropenia, thrombocytopenia).
Clinical studies: IBD treatment safety
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The septicaemic isolates were observed to produce cytotoxic changes in high dilutions of culture filtrate.
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At the same time it increases the cytotoxic action of macrophages in destroying tumor cells by stimulating the production of lymphokine interleukin.
THE NATURAL REMEDY BIBLE
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Your doctors in Washington tried the usual cytotoxic, anti-cancer, drugs.
THE AMBASSADOR'S WOMEN
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Aim To investigate the cytotoxic activity of HDAC inhibitor Trichostatin A (TSA)combined with anticancer drugs targeting DNA on T24 bladder cancer cell line.
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She was subjected to an intensive combination of cytotoxic drugs and cranial radiotherapy.
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The ability to distinguish between the two cell types is not complete, and cytotoxic drugs cannot avoid causing some damage to normal cells.
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Supervised clinical training is provided in cytotoxic drug treatment and radiation therapy.
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Vitamin C is directly cytotoxic to certain cancer cell lines in vitro.
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Your doctors in Washington tried the usual cytotoxic, anti-cancer, drugs.
THE AMBASSADOR'S WOMEN
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Unsaturated aldehydes are often cytotoxic, and many of them are precursors of fluorescent products.
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In this study, the cytotoxicity of various sub-fractions of dichloromethane extract isolated from the leaves of S. crispus was determined and the anticancer activity of one of the bioactive sub-fractions, SC/D-F9, was further analysed in breast and prostate cancer cell lines.
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Earlier studies indicated that the fibrils themselves were the cytotoxic form of amyloid peptides.
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Schwartz A, Middleton E Jr In previous studies (Schwartz et al., 1982) we showed that the naturally occurring plant flavonoid quercetin can inhibit both the in vitro generation and effector function of alloantigen specific cytotoxic T lymphocytes (CTL).
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IgG2a isotype antibody is known to be more effective than other isotypes in clearing virus infection via multiple mechanisms including complement activation, stimulation of antibody-dependent cellular cytotoxicity and clearance of opsonized virus by macrophages
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The catalytic antibody technology can localize the delivery of a cytotoxic drug to a specific cell or cancer type.
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PCIB) reported today that it has completed the successful treatment of the second dose group in the phase I/II study of its proprietary photosensitiser Amphinex (R) used in combination with the cytotoxic agent bleomycin in cancer patients.
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With cellular immune response, specific cytotoxic T cells are formed.
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Yervoy works by blocking a protein on the surface of T cells, the soldiers of the immune system, called cytotoxic T-lymphocyte antigen 4, or CTLA-4.
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These findings are similar to those in obese rats, which have reduced NK cell cytotoxicity which is restored upon weight loss
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This notion is also supported by the observation that substitution of salubrinal with subtoxic concentrations of the phosphatase inhibitor cantharidin induced a comparable increase in PSI-mediated cytotoxicity, whereas the PP2B / calcineurin inhibitor cypermethrin proved to be ineffective.
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The free radicals and reactive species produced by these reactions are highly cytotoxic.
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We attributed the reduced cytotoxicity at higher repetition rates to the contribution of the oxygen-independent mechanism.
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The authors give an account of the basic concept and classification of cytotoxic drugs.
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The 10-year study began with an EPA grant to develop mammalian cell lines that would be used specifically to analyze the ability of these compounds to kill cells, or cytotoxicity, and the ability of these emerging disinfection by-products to cause genomic DNA damage.
Disinfectants Used To Purify Water Create Toxic By-Products | Impact Lab
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Physician office laboratories that handle cytotoxic drugs are required to have special procedures for handling these agents.
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Central venous catheters are used for haemodynamic monitoring, giving vasopressors and cytotoxic drugs, sampling blood, and giving fluids and parenteral nutrition.
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Supervised clinical training is provided in cytotoxic drug treatment and radiation therapy.
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The strong cytotoxic activity of our UCB-derived NK cells against various tumor cell lines as well as the cytolysis of primary AML cells were displayed by specific lysis, CD107a-mediated degranulation and the production of IFNγ.
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The immune system, sensing trouble, then sends forth white blood cells called cytotoxic lymphocytes, or CTLs, to destroy the affected cells.
Can He Find A Cure?
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Cytotoxicity of GCV on cell cultures was determined using Cell Proliferation Kit I (MTT) (Roche, Mississauga, ON) according to the manufacturer's instructions. pAlb-vTK was digested with BstXI and HindIII to yield a 5134 bp minigene containing the murine Alb p/e with the downstream vTK coding region which was microinjected into fertilized oocytes prior to their transfer into the oviducts of pseudopregnant FVB/N mice using standard procedures
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Objective To investigate the potential influence of zinc deficiency and excessiveness on the differentiation and cytotoxicity to mice embryo limb bud cells.
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So routine cytotoxic anti - tumor medicine are not competitive with mono antibody anti - tumor medicine in clinical application.
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Pathological change is chronic and continual advancement, patients can emerge renal inadequacy, uraemia. excitatory autacoid and cytotoxic drug have bad curative effect and major adverse reaction.
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When white blood cells known as cytotoxic T lymphocytes (CTLs) spot certain combinations of HLA molecules and viral epitopes, they attack the infected cells.
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Leukocidin is a pore-forming protein that has cytotoxic effects on host cells.
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The control experiment with ascorbate alone shows no noticeable cytotoxic action of sodium ascorbate.
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None of the sterols tested at this level induced cytotoxicity as measured by lactic dehydrogenase release.
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The fibrils formed by the hexapeptide were also cytotoxic toward the pancreatic cell line.
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My group synthesized several new classes of antitumor peptides such as LH-RH antagonists, somatostatin analogs, bombesin/GRP antagonists, GH-RH antagonists and targeted cytotoxic analogs of LH-RH, bombesin and somatostatin.
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The Authors suggested that the absorption of anandamide by PMX might abolish the diverse negative effects of anandamide such as hypotension, immunosuppression, and cytotoxicity.
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Tumor cell death caused by radiation can induce DC-mediated cytotoxic T-lymphocyte (CTL) responses and long-term antitumor immunity [
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It has been suggested that sequestration of bile acids by intracellular bile acid binding proteins may also protect cells from bile acid cytotoxicity.
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It's true that these compounds aren't in the same side-effect league as, say, the old cytotoxic agents like cisplatin, but they're a long way from the lasering-in-on-the-single-important-factor storyline from a few years ago.
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OSLO - (Business Wire) PCI Biotech AS (PCIB. OL) (OSE: PCIB. reported today that it has completed the successful treatment of the second dose group in the phase I/II study of its proprietary photosensitiser Amphinex® used in combination with the cytotoxic agent bleomycin in cancer patients.
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Based on this demonstration of receptors for peptides in various tumors, I started in 1995 the development of modern cytotoxic analogs of LH-RH, bombesin and somatostatin, which can be targeted to peptide receptors on various primary cancers and their metastases.
Andrew V. Schally - Autobiography
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She was subjected to an intensive combination of cytotoxic drugs and cranial radiotherapy.
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It can be concluded that iodinated derivatives of hypericin do not show an increased cytotoxic effect upon irradiation in either monolayers or spheroids.
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Administration of intravenous therapy is associated with considerable risk for example, patients have died when cytotoxic drugs have been given intrathecally instead of intravenously.
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Thus it appears that PHP-mediated cytotoxicity proceeds through both membrane and mitochondrial photosensitization.
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Nurses usually prepared and administered intravenous drugs on the wards, but cytotoxic drugs were prepared centrally by the pharmacy department.
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Antigen density on the tumor cell surface influences the cytotoxic sensitivity.
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Concerning the biological activity, especially of the antitumour and cytotoxic nature already identified in this plant, this study identified other structures that had never been stated before and demonstrated other therapeutic activities such as antiviral, and the pharmacological effect at the level of platelet aggregation and cardiac ailments.
Chapter 12
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Antigen density on the tumor cell surface influences the cytotoxic sensitivity.
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Cytotoxic and cytostatic gene transfer strategies were developed and tested in animal models of arterial injury.
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Compared with cytotoxic photoprotectants like herberine, palmatine and acriflavine, the anionic dyes have no adverse effects up to a concentration of 1 M.
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As for safety, most drugs caused the usual signs of cytotoxicity, including neutropenia, thrombocytopenia, fever, infections, and gastrointestinal toxicity.
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A wide variety of agents has been discovered that stabilize such structures and exert cytotoxic effects on cells in culture.
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Pores in membranes can be induced by cytotoxic peptide antibiotics and by peptide fragments of viral glycoproteins.
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Using the membrane permeabilising saponin digitonin, we measured digitonin applications of different concentrations in cytotoxicity assays over 18 h alone to normalise the data of the combination treatment of EGCG and digitonin against the toxic effect the adjuvant already determines alone.
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Because bioreductive drugs are activated to form highly effective cytotoxins under hypoxic conditions, they can be used to inactivate hypoxic tumor cells that are refractory to the direct cytotoxicity of hypericin-PDT.
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All the three proteoglycans stimulated mice thymocyte and splenocyte proliferation and elevated cell cytotoxicity.
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A hospital doctor has been charged with manslaughter over the death of a teenager who was wrongly given a spinal injection of a cytotoxic drug meant for intravenous use only.
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The initial photooxidative injury triggers a number of responses, including direct cytotoxicity within the tumor microenvironment.
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In vitro, these peptides inhibited cytotoxicity and differentiation of cytotoxic T cells.
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Determine the dispersant concentration that induced cytotoxicity in multiple cell lines and derive an aggregate measure of cytotoxicity that could be use to rank order the chemicals and to compare with in vivo toxicity data obtained in aquatic test species.
Georgianne Nienaber: Does EPA Test for Endocrine Disruptors in Corexit Tell Us Anything?
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Destruction of the red cells occurs as a result of the red cell-bound autoantibodies to the Fc receptors on monocytes and macrophages; phagocytosis and cytotoxic lysis of the red cells subsequently occur.
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The composite did not exhibit cytotoxicity in the filter diffusion tests.
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Cytotoxic components of Zingiber zerumbet, Curcuma zedoaria and C. domestica.
Chapter 28
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Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic and semiallogeneic system.
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Objective To investigate the cytotoxicity of alcohol on hepatic and neuronic cells of rat and.
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Likewise, the suppression of the cellular immune response can be determined using well known in vitro analyses, e.g., proliferation and cytotoxicity assays or characterization of activation phenotypes of peripheral blood lymphocytes by, e.g., flow cytometric analysis.
FreshPatents.com: Notable Patent Applications - 07/22/2010
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The superoxide generated may have a direct cytotoxic effect or it may interact with inflammatory mediators to modify the inflammatory process.
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Data from such experiments can be misleading since lipid peroxidation products are cytostatic and cytotoxic; and anticancer drugs that generate oxidative stress in biological systems can enhance this effect.
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Consistent with the established role of p53 in chemotherapy-induced cytotoxic/cytostatic effects, treatment with
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A woman was exposed to a possible teratogen such as a live vaccine or cytotoxic drug when she was not protected by effective contraception.
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Cytotoxicity of conjugates may be influenced by many factors, including drug loading, side-chain hydrophobicity and net charge, which may ultimately affect singlet oxygen generation.
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One called helper T cells and the other called cytotoxic T cells
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The superoxide generated may have a direct cytotoxic effect or it may interact with inflammatory mediators to modify the inflammatory process.
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Witte et al. determined that subtoxic concentrations of membrane-damaging compounds enhanced the cytotoxicity of hydrophilic xenobiotics.
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* Indeed, the relative paucity of genetic aberrancy in this leukemia may be one reason that this tumor is so easily felled by cytotoxic chemotherapy.
The Emperor of All Maladies
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ANTITUMOR Immune enhancement; activating macrophages, T cells, and NK cells; increasing TNF-α production; inducing cancer cell apoptosis and cytotoxicity
Forever Young
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As the prodrug is metabolically converted to its cytotoxic form, it penetrates the cell bearing the bound enzyme as well as ‘naked’ cells that are nearby.
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The remainder, which includes body parts and the cytotoxic material, will be incinerated abroad.
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IgG2a isotype antibody is known to be more effective than other isotypes in clearing virus infection via multiple mechanisms including complement activation, stimulation of antibody-dependent cellular cytotoxicity and clearance of opsonized virus by macrophages
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It works by blocking a molecule known as cytotoxic T-lymphocyte antigen or CTLA-4, which is believed to play a role in hampering the ability of the body's immune system to fight cancerous cells.
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Nurses usually prepared and administered intravenous drugs on the wards, but cytotoxic drugs were prepared centrally by the pharmacy department.
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Another key finding was that intervention patients showed higher levels of three key markers of immune system function after 12 months: natural killer cell cytotoxicity and Con A and PHA blastogenesis.
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Qualitatively, no difference was observed in the cytotoxicity of unheated, heated and ultra filtered culture supernatants of isolates.
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Active cytotoxic agents for patients with advanced KS with the longest track records include vinca alkaloids, anthracyclines, bleomycin, and etoposide.
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Optics and optical instruments - Contact lenses - Determination of cytotoxicity of contact lens material - Part 1: agar testinhibition test.
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Liposomal envelopes can transport sensitization of cells in a tumor to a particular substances across cell membranes which would cytotoxic drug, thus obtaining enhanced therapeu - otherwise be repelled by the hydrophilicity of the tic response, permitting the use of lower doses of gene construct.
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Drug treatment of cancer is often limited by unwanted tissue damage due to the lack of tumor selectivity of the cytotoxic agents administered.
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We currently have an opportunity for a cellular immunologist preferably with 4 to 6 years industrial/biotech experience and who is able to perform immunological assays (flow cytometry such as intracellular cytokine staining, assays,, ELISPOT, cytotoxicity assays, Th1/Th2 cytokine response assays, cell culture etc).
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The benefit of cytotoxic agents such as cyclophosphamide has not yet been established.
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Spider venom falls into two categories: neurotoxic and cytotoxic.
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These proteins, which inhibit the cytotoxic activity of the E colicin DNase proteins, preventing the death of the colicin-producing bacteria, have 60% sequence homology and have the same three-dimensional structure.
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Cucurbitacins are oxygenated tetracyclic triterpenes that have been shown to have emetic, antineoplastic, and cytotoxic effects on herbivores, resulting in feeding and oviposition deterrence and reduced growth of consumers.
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Immune cells, called cytotoxic or killer T cells, for example, express T-cell receptors that bind to the MHC head domain and the bound peptide.
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E. coli CS31A fimbrial subunit precursor (Genbank M59905), heat-stable toxin, STa Shiga-like toxin types 1 and 2, stx1 and stx2, cytotoxic necrotizing factors 1 and 2 (cnf1 and cnf2), and intimin-γ (eae),.
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Ganciclovir is a guanosine analog that becomes strongly cytotoxic when phosphorylated.
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Supervised clinical training is provided in cytotoxic drug treatment and radiation therapy.
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For example, often a chemical is tested with both human and animal cells to study its ability to produce cytotoxicity, mutations, and DNA damage.
Risk assessment of chemical substances
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Antigen density on the tumor cell surface influences the cytotoxic sensitivity.