How To Use Cytochrome In A Sentence
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Cytochrome P 450 s are a large group of heme - binding enzymes and widely distribute in biology.
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Presently, it is believed that carbon monoxide binds to cytochrome oxidase and consequently, disrupts the mitochondrial respiratory enzyme system. 5,8-11 Experimental studies seem to indicate that delivery of CO dissolved in the serum to the cells, and not blockage of oxygen transport by the COHb bond, is perhaps more important in the sequence of pathological events of the poisoning. 3,14 Although in severe poisonings, all factors may contribute to the outcome of the case.
Carbon Monoxide
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EPR-and light absorbance spectroscopy [3]; mouse macrophage enzyme: cytochrome P-450 type hemoprotein [9]; naturally occuring neuronal mutant with a 105-amino acid deletion in the heme-binding domain as a result of in-frame mutation by specific alternative splicing, contains heme, but shows no l-arginine and NADPH-dependent citrulline-forming activity in presence of Ca2+ - promoted calmodulin, the heme coordination geometry is highly abnormal [28];
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Iron is used in actively proliferating cells for cytochrome and DNA synthesis.
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Cytochrome oxidases are the terminal enzymes of aerobic electron transport phosphorylation.
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Woese then hazarded that such chimerism probably would not prove a significant problem, from the example provided by congruent alpha-proteobacterial trees based on cytochromes c and rRNA, from the general robustness of the rRNA phylogeny, and from its ability to predict certain domain-level phenotypic characters (for instance, the differences in bacterial and archaeal cell envelopes, transcription, and translation).
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The many hundred known forms of cytochrome P450 are notably involved in detoxification of xenobiotics and steroid biosynthesis, but also in adverse reactions such as activation of procarcinogens.
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Our previous results indicated that cytochrome P450 destruction by benzene metabolites was caused mainly by benzoquinone.
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Our findings suggest that several regions of the cetacean cytochrome b protein have experienced molecular adaptation.
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The active site or prosthetic group of all the cytochromes is an iron containing porphyrin, or heme.
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This would be in agreement with previous computer simulations of the permittivity of cytochrome c.
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Respiration in wheat endosperm was measured together with the activities of citrate synthase and cytochrome oxidase.
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However, the addition of purpurin to oxidized cytochrome c in the absence of microsomal fraction demonstrated low level but dose-dependent ‘reductase-like’ activity.
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< 2,3 > pMMO: 2 iron molecules per mol of enzyme [23]; < 2,3 > sMMO: the a-subunit of component A contains a non-haem bis-mi - cro-hydroxo-bridged binuclear iron centre [23]; cytochrome component contains 1 atom iron per molecule [2]; protein A, hydroxylase compo - nent: contains a binuclear iron center [4];
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In the discussion, the authors present additional evidence that supports their finding, including, but not limited to: (a) the inability to detect cytochromes within the methanogens; (b) the fact that the cell walls of methanogens do not contain peptidoglycan; (c) the 23S rRNA sequence is also divergent from typical bacteria.
Archive 2008-07-01
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Internal structural water molecules seem to play an important role in proton conduction in membrane proteins like bacteriorhodopsin, the photosynthetic reaction center, and cytochrome-c oxydases.
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In addition, mast cells in normal colon, adenoma, or carcinoma samples consistently showed strong positive staining for cytochrome P450 3A.
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The findings add to an accumulation of evidence suggesting that inhibition of the cytochrome P450 2D6 isozyme (CYP2D6) may adversely affect outcomes in breast cancer patients taking tamoxifen.
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Previously described protocols were used for isolation of mitochondria and generation of cytochrome spectra.
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Woese then hazarded that such chimerism probably would not prove a significant problem, from the example provided by congruent alpha-proteobacterial trees based on cytochromes c and rRNA, from the general robustness of the rRNA phylogeny, and from its ability to predict certain domain-level phenotypic characters (for instance, the differences in bacterial and archaeal cell envelopes, transcription, and translation).
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The paper focuses on genes involved in metabolizing and disposing of xenobiotic chemicals, such as those in the cytochrome P450 gene families.
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Toxic electrophilic compounds produced by both cytochromes P450 and microsomal epoxide hydrolases can be eliminated from the body by conjugation with glutathione.
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The majority of iron in humans is located in the porphyrin ring of heme that is incorporated into proteins and enzymes such as myoglobin, hemoglobin, cytochromes, catalases, and peroxidases.
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Respiration in wheat endosperm was measured together with the activities of citrate synthase and cytochrome oxidase.
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The cytochromes P450 are a superfamily of haemoproteins that catalyse the oxidation of a number of endogenous and xenobiotic substances.
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Researchers found differences in 10 genes around an enzyme called cytochrome P450 1b1, which is known to break down estrogen and tobacco smoke.
Lung Cancer in Women on the Rise
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An unexpected result is that ouabain and amiloride, which do not react directly with cytochrome c oxidase, modify significantly the absorption of the photoacceptor (mirrored by the action spectrum in our case).
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Sequence data from the mitochondrial cytochrome-b gene and the hypervariable control region as well as 7th intron of the nuclear fibrinogen gene show these 2 taxa to be reciprocally monophyletic.
Archive 2008-11-01
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They all belong to a major family of enzymes called cytochrome P450 that act as a catalyst for a broad range of chemical reactions and are implicated in pesticide resistance in other insect species.
Why Bedbugs Won't Die
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Hemoglobin, myoglobin, cytochromes, and other proteins are involved in oxygen transport and utilization.
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A relatively new drug, atovaquone, which interfered with a different step in P. falciparum metabolism, can be countered by a single amino acid mutation in a protein called cytochrome b.3 The very latest drug, artemisinin, is derived from the Chinese sweet wormwood plant.
The Edge of Evolution
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Phylogenetic relationships of the five extant rhinoceros species (Rhinocerotidae, Perissodactyla) based on mitochondrial cytochrome b and 12S rRNA genes.
Archive 2006-09-01
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Our first protein target was cytochrome c because it contains a positively charged surface made up of several lysine and arginine residues.
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Cytochrome P450-based suicide gene therapy for cancer using prodrugs such as cyclophosphamide (CPA) increases anti-tumor activity, both directly and via a bystander killing mechanism.
BioMed Central - Latest articles
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The active site or prosthetic group of all the cytochromes is an iron containing porphyrin, or heme.
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They included four oropendolas and four caciques in a molecular study of blackbird relationships using cytochrome-b sequence data.
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It is a fundamental metabolic pathway needed for biosynthesis of cytochromes, chlorophylls, phycobilins, and the corrin nucleus of vitamin B 12.
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It was attributable to the electrogenic reaction in the cytochrome bc 1 complex.
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'' CYP2C9 '' is an [[isoenzyme]] of cytochrome P-450., mainly among Caucasian patients as these variants are rare in African American and most Asian populations.
Citizendium, the Citizens' Compendium - Recent changes [en]
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Humans have an enzyme called cytochrome P450 3A4 that helps to metabolize calcium channel blockers and clear them from the system.
The Seattle Times
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In some respects of isozyme zymogram of cytochrome oxidase and peroxidase exist obvious difference.
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T), in the unfolded state of apocytochrome C and reduced BPTI.
Journal of Physical Chemistry B
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185, 960-966 (1992) [9] White, K.A.; Marletta, M.A.: Nitric oxide synthase is a cytochrome P-450 type hemoprotein.
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Despite this, recent studies of microsatellite DNA loci and cytochrome b mitochondrial DNA show small and non-significant genetic differences based on samples from three wintering and four nesting areas in arctic North America, Russia, and Greenland [52].
Effects of climate change on the biodiversity of the Arctic
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49-52 (1994) [6] Hanioka, N.; Watanabe, K.; Yoda, R.; Ando, M.: Effect of alachlor on hepatic cytochrome P 450 enzymes in rats.
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DavidDP at 7.27: ever come across something called cytochrome C?
John Terry’s sacking as England captain tells us something interesting...
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Frölich and Würgler constructed a strain with increased cytochrome P450-dependent xenobiotic metabolism which facilitates the detection of promutagens.
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Woese then hazarded that such chimerism probably would not prove a significant problem, from the example provided by congruent alpha-proteobacterial trees based on cytochromes c and rRNA, from the general robustness of the rRNA phylogeny, and from its ability to predict certain domain-level phenotypic characters (for instance, the differences in bacterial and archaeal cell envelopes, transcription, and translation).
A Disclaimer for Behe?
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During Phase I detox at least 120 members of the enzyme family known as cytochrome P450s pretreat the hundreds of thousands of toxins that your body encounters every day.
The Source
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I can rattle on about cytochromes, about chemiosmotic potentials and ATP synthase.
"I will show you fear in a handful of dust...."
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Various intermembrane space (IMS) proteins, such as cytochrome
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R.M.; Croteau, R.B.: Molecular clon - ing of a cytochrome P450 taxane 10b-hydroxylase cDNA from Taxus and functional expression in yeast.
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In vitro inhibition of multiple cytochrome P450 isoforms by xanthone derivatives from mangosteen extract, Drug Metabolism
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All of the rifamycins are inducers of a variety of metabolic pathways, particularly those involving the various isozymes of the cytochrome P450 system.
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ResultsSome Chinese herbal medicine can reduce or induce CYP3A4 isoform of cytochrome P450. Consequently it affected combined drug metabolism and resulted in drug interaction.
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Copper functions in many enzyme systems, such as lysyl oxidase, ceruloplasmin, cytochrome oxidase, tyrosinase, and Superoxide dismutase.
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Warren et al. estimated rates of divergence for both ND3 and cytochrome b for two clades of Indian Ocean sunbirds using estimates of island age.
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In addition to morphomechanical changes, hDMPK A expression induces physiological changes like loss of mitochondrial membrane potential, increased autophagy activity, and leakage of cytochrome c from the mitochondrial intermembrane space accompanied by apoptosis.
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Utilizing such techniques on cytochrome C, Fitch and Margoliash (1967) have pro - duced a phylogenetic tree linking fungi, yeasts, nema - todes, fish, birds, and mammals, which is very similar to phylogenetic trees proposed by classical zoologists.
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