How To Use Complication In A Sentence
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Nulliparous women are reportedly at a higher risk of developing complications of pregnancy and delivery than multipara.
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The following data on the electric conductance of F 0 were obtained in the presence of myxothiazol, to avoid the complications caused by the electrogenic and proton pumping activity of bc 1.
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It's not triggered by wintry weather but the risk of complications is.
The Sun
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Dave couldn't find his passport at the airport and then there were further complications when Fiona lost her baggage.
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Of these, 250 are hospitalized as a result of acute complications, and approximately 100 die from cirrhosis, liver cancer, or fulminant hepatitis.
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The complications are considerable, because the wildest creatures live in the wildest places.
Times, Sunday Times
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That may seem unthinkable now, but it is wise to plan for complications.
Times, Sunday Times
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Complication of mechanical ventilation in neonates with respiratory distress.
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Using traced photos, Breslin's snapshot style gets at the scenario's serio-comic complications.
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Methods In this retrospective study, The operation indication, result and complication fo 11 consecutive cases of artificial iris diaphragm implantation for silicone oil support eye were studied.
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Allergic bronchopulmonary aspergillosis is most often a complication of asthma or cystic fibrosis.
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Potential lethal cardiac arrhythmias and convulsions are recognised complications of both iatrogenic and self inflicted overdoses.
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There was also a statistically significantly lower incidence of leukocytopenia, or decrease in white blood cells, of 12 percent on Treanda versus 38 percent with CHOP, and more infectious complications with CHOP, Rummel said.
FinanzNachrichten.de: Aktuelle Nachrichten
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We always try to avoid any unnecessary complications.
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Posterior Inferior Cerebellar Artery Infarction: An Unusual Complication of Posterior Spinal Fusion Surgery in an Adolescent with Idiopathic Scoliosis.
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Common complications were snap of temporomandibular joint hemimandibular , restriction of mouth opening and facial nerve injury.
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Accurately assessing nutritional requirements and monitoring the adequacy of nutritional intake in critically ill patients can help ensure that complications associated with underfeeding or overfeeding are avoided.
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In fact, some 'loads' abusers have ingested up to 12 grams of glutethimide and greater than 2.5 grams of codeine (often in combination with acetaminophen or aspirin) on adaily basis. 5 Complications from chronic abuse should also be considered.
Loads
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A final complication in attempting to assess combat power is the impact of air power on ground operations.
NATO's Changing Strategic Agenda
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Ten percent to 21 % of diabetics have nephropathy, or kidney disease, a frequent complication of diabetes.
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High-volume syringe exchangers may be the most frequent injectors, resulting in more medical complications; however, no health-specific data were available for NEP participants, thus this hypothesis could not be tested.
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Most ocular complications involve the cornea but may also include the conjunctiva, uvea, sclera, retina, and surrounding structures.
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Avascular necrosis of head of femur: femur (lntracapsular fracture): a. Common complication of intracapsular fracture a. Coxa vara. neck femur. b.
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Splenectomy effectively arrests the extravascular hemolysis and prevents its long-term complications, such as cholelithiasis and aplastic crises.
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These conditions are causing complications such as encephalitis, pneumonia, diarrhea and conjunctivitis.
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He had been admitted to hospital with breathing difficulties and passed away early yesterday after suffering from complications of the condition he had battled for 32 years.
The Sun
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I have been in hospital because of problems following a complication from a throat operation.
The Sun
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For reasons of the heart, I was later obliged to dive into Italy's Caffeinated Complications: ristretto vs. espresso, lungo vs. Americano; black vs. 'stained' with warm/cold milk; served in a glass vs. a cup -- and so on.
Juliet Linley: Koffee for Kids?
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They diagnosed cystitis and then they diagnosed nephrolithiasis & then they diagnosed Malta fever with ovarian complications & then they went all hush-hush while they diagnosed a tuberculous infection so that I couldn't possibly guess what they were testing for.
Another piece of the puzzle
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Infectious complications of medical devices are often not considered in the context of reporting, and so the possible lessons that can minimise recurrence remain unlearnt.
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Infertility is one of the complications of this type of radiotherapy.
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These complications may be minimized by passing all arthroscopic instruments through sturdy metallic sheaths to prevent multiple attempts at hip joint penetrance and perforations of the hip capsule.
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CoNS PVE is associated with a high rate of methicillin resistance and significant valvular complications.
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In this programme she revisits them to hear about the emotional ups and downs and complications of interracial adoption.
Times, Sunday Times
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Perforation is a rare complication of intestinal carcinoid tumor. Only 11 cases have been reported in the literature and most of them were located at the ileum, appendix, and Meckel's diverticulum.
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Then, somewhat more alarmingly, there is the hunger for a voluntarist transcendence of the limitations of history, the fantasy of escaping from the inextricable complications and complexities of the past into some pure state of agency.
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Gastric inflation is a dangerous complication of using laryngeal mask airways in advanced life support
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The article by Wallach in this issue reminds us that even such a frequently used and seemingly benign procedure as cannulation of the radial artery can result in serious complications.
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A full screen to exclude STIs is essential to avoid delayed diagnosis and possible long term complications.
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The patient described in this report had every major complication of Caroli disease, including recurrent cholangitis, liver abscess, biliary lithiasis, and cholangiocarcinoma.
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England have the added complication of food poisoning sweeping the camp.
The Sun
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She died when he was 14 after suffering complications from a hysterectomy operation.
Times, Sunday Times
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Complications arise during the surgery, but a cliffhanger ending leads the audience to wonder if Dr. Brown has managed a second miracle.
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The complications of tetany and hypoparathyrodism were not understood.
Emil Theodor Kocher
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Conclusion The recurrence of leishmaniasis was related with patients' residential area, occupation, age, length of the illness course, complications, dosage of antimonials.
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France's Foreign Minister Alain Juppe later told reporters his country was in the process of unfreezing $250 million in Libyan assets, but added that this could take time due to legal complications.
U.S. Recognizes Libyan Rebel Group
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He slipped on an orange peel, fell, and succumbed to complications.
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Horses Mouth January 22, 2007 4:24 PM
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Complications of mumps include meningitis, encephalitis and deafness.
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However, potential complications include: bleeding infection skin blistering, scarring or ulceration nerve damage injury to surrounding structures (skin, nerves or organs) allergic reaction to X-ray dye or sclerosant blood in the urine
Sclerotherapy
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Objective : To enhance the awareness of pulmonary complications of acquired immunodeficiency syndrome ( AIDS ).
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The fact that a coastguard was the first on board may save some complications later on, in the
Dracula
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However, more than twice as many (4.7 per cent) suffered '' '' genitourinary '' '' complications.
Undefined
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Walter Cronkite, American icon and broadcast journalist died in his home in New York City on July 17, 2009 of complications with cerebrovascular disease, a dysfunction where the blood vessels restrict bloodflow to the brain.
Get 1000s of People To Look At Your Business in FIVE Months breakthrough – myFiveBest
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Since the party's preferred historical narrative casts it as the only begetter of China's liberation and subsequent rise, this awkward complication is hard to overlook.
China's Confucian makeover | Isabel Hilton
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When poor women cannot get basic prenatal care, for example, they and their newborns are more likely to suffer complications requiring round-the-clock intensive care.
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The most common complication of laser resurfacing is hyperpigmentation - skin tone that turns darker than normal.
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Diabetic nephropathy is one of the common complications of diabetes. The review has summarized the vascular endotheliocyte trauma and blood coagulation fibrinolysis.
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Unfortunately, Toni reflected, even war could not eliminate the emotional complications which beset man's life.
IN LOVE AND WAR
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The fact that a coastguard was the first on board may save some complications, later on, in the Admiralty Court; for coastguards cannot claim the salvage which is the right of the first civilian entering on a derelict.
Dracula
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The risk of serious complication was lower in those who had treatment for diabetes.
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Mikey, Mr. Czech's only son, died three years ago from complications associated with diffuse intrinsic pontine glioma, a rare, inoperable brain cancer.
Son's Death Inspires Fight Against Brain Cancer
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More Infections Often Tied to Food According to WHO, of more than 1,600 people sickened by this E. coli strain, 499 developed a rare and potentially fatal kidney-failure complication known as hemolytic uremic syndrome—a complication that can shut down the kidneys and normally occurs in only a small percentage of people sickened during an E. coli outbreak.
Rare Germ Drives Outbreak
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End users also must conduct performance testing and product compliance with the added complications of field service troubleshooting and fault isolation.
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In view of the complication of surfactant screening in tertiary recovery, the surfactant model reducing oil-water intension has been established so as to optimize the surfactant screening method.
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Complications included cerebrospinal fluid fistula in 1 case, mild facial paresis in 2, facial numbness in 6 and labial herpes in 11.
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The key to your success is to ensure your originality shines through, so try to avoid unnecessary complications with friends or co-workers.
The Sun
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If you want to take things further you can, but it adds a little extra complication to the proceedings.
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Pneumonia, bronchitis, and sinus and ear infections are three examples of complications from flu.
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Bacterial complications are: Infections of nose and pharynx, sinuses, infections of the bronchi, the lungs and the middle ear.
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The most serious complication is respiratory failure from airway obstruction or hypoventilation.
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Anyone with slight complications in their tax affairs is likely to be asked to fill in a return.
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A bone marrow transplant cured the problem, but complications followed with his heart, which meant more surgery.
Times, Sunday Times
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If the leper is in hiding, he cannot be operated upon, the necrosis will continue to eat its way up the bone of the leg, and in a brief and horrible time that leper will die of gangrene or some other terrible complication.
Chapter 7
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There are two further complications that the logic of state enterprise suggests are likely to occur.
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Hepatic hydrothorax is a complication of cirrhosis in patients with ascites.
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Which means getting help pronto, before any complications kick in.
The Sun
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Portal hypertension with bleeding varices is a serious complication of cirrhosis that can be treated surgically and with drug therapy.
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Without it I wouldn't know if the area became damaged or infected, leading to possible nasty complications.
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This will help prevent complications such as rheumatic fever or an abscess around the tonsils.
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He had juvenile diabetes, anemia, a skin infection, and so many other complications that Hill can't even recall them all.
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A complication such as cholecystitis is quite common.
Xml's Blinklist.com
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Researchers concluded that PNH patients with hemolysis are at an increased risk of mortality and life-threatening complications, and that hemolysis is a potential risk factor for mortality and life-threatening complications independent of the presence of cytopenia.
Hemolysis Is Associated with Increased Mortality and Thrombosis in Patients with PNH - Yahoo! Finance
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Larger scale studies may be needed if important clinical differences between colloids and crystalloids are to be found (including the possibility that dextran may worsen bleeding complications).
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If people cannot be brought to an interest in one another greater than they feel to-day, to curiosities and criticisms far keener, and co-operations far subtler, than we have now; if class cannot be brought to measure itself against, and interchange experience and sympathy with class, and temperament with temperament then we shall never struggle very far beyond the confused discomforts and uneasiness of to-day, and the changes and complications of human life will remain as they are now, very like the crumplings and separations and complications of an immense avalanche that is sliding down a hill.
An Englishman Looks at the World
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Doctors also discovered a small perforation in her bowel, which led to severe complications, an inquest heard.
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This condition involves the heavy gluteal muscles and may occur as a complication of azoturia, or a lameness of the hind limb that is usually due to a spavin.
Common Diseases of Farm Animals
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Ignoring an ingrown toenail may lead to more serious complications later, such as infections that can spread right down to the bone.
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She developed complications after the surgery.
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There has been the hope that we could accomplish the same thing with the complications of type 2 diabetes by a similar surge of intensive treatment aimed at bringing about near normoglycemia.
Archive 2008-02-01
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Complications seen in a hiatal hernia include aspiration pneumonia and peptic esophagitis with stricture.
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Complications kick in, and previously contained feelings of jealousy, betrayal, insecurity and possessiveness threaten to overwhelm what had seemed a rather civilised arrangement.
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If there are serious respiratory complications go to the doctor and let the doc determine if hospitalization is necessary.
Sebelius on swine flu: 'We're preparing for the worst'
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The most common complication of the surgery is skin-flap slough, leading to a recurrence of the problem.
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-- The usual signs of fracture in connexion with some serious complication, such as laceration of bladder or rectum, injury to the peritoneum, division of arteries and veins.
An Epitome of Practical Surgery, for Field and Hospital.
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After four months, a new cartilage surface for the humeral head had grown in place, with no complications or adverse effects, the researchers reported.
Need a new hip? Someday you may grow your own
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Conclusion New method of caesarean birth of operatic time was short, complication decrease, simple and easy.
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What follows is a story of a person, in his own words, who dealt with a language company called Interac in Yokohama, which disciplined him for being late for classes despite his explanation that his pregnant wife was undergoing complications.
Debito.org
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Corneal abrasions typically heal without serious complications over time with supportive care: ice compresses and nonsteroidal anti-inflammatory eye drops.
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Any luxated tooth that interferes with normal occlusion requires immediate dental evaluation and treatment to avoid pain and further complications.
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A potential corollary benefit of reducing duration of mechanical ventilation is a reduction in ventilator-associated complications.
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Intraoperative complications are uncommon, though haemorrhage, haematoma, and cystotomy may occur.
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The factors influencing the prognosis on omphalocele include the opportune moment of surgical repair, the type of omphalocele, the weight at birth, the accompany malformation and complication.
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Christopher S. Wenckus, head of the endodontics department at the University of Illinois at Chicago's College of Dentistry, said deaths or serious complications following root canals are "horribly uncommon.
Chicagotribune.com - News
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The situation is already difficult because of the steepness of the slope without the complications imposed by the roots.
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Ivester, 50, had been considered heir apparent to replace Goizueta, who died Saturday from complications related to lung cancer.
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These geriatric patients often have multiple comorbidities, as well as a high risk for post-operative complications.
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Potential complications include: bleeding infection allergic reaction to X-ray dye (contrast reaction) dimpling or paleness at the injection site nerve injury injury to the eardrum (with TMJ only)
Therapeutic Joint Injections
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This last example highlights a further complication.
Fascists and Conservatives
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Whatever your personal preferences, it is fair to say that neither method is easy, painless or complication free.
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The fact that the plane was late added a further complication to our journey.
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I understand that there are mitigating circumstances, programming complications, contracts, etc.
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The plot complications are tortuous, their resolutions unsatisfying and the characters thin.
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In some persons, particularly children under 5 years of age and the elderly, the infection can also cause a complication called hemolytic uremic syndrome (HUS), in which the red blood cells are destroyed and the kidneys fail.
Escherichia Coli O157~H7
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Spontaneous bacterial peritonitis is a common complication of cirrhosis, with high mortality.
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But four per cent had chronic problems and complications that lingered for years.
The Sun
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The horse threw the king, and, he died days later from the complications of a broken collarbone.
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It had all the complications of the human mechanism, all the liability of getting out of repair, and it could not be replaced with the ease and immediateness of the human being.
Mark Twain: A Biography
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Many now encourage healthy children 6 to 23 months old to be vaccinated as they are at a heightened risk of hospitalization from flu-related complications.
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Transplantation remains the sole curative therapy for the disease, although it too is not without the potential for severe complications.
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Ascending infection in women leads to the major complication of gonorrhea, pelvic inflammatory disease, a common cause of female infertility.
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Another complication is that sometimes there seems no way to resolve the antinomies, as in the case of the divisibility of matter.
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Clinical evaluation may detect gastrointestinal, neurologic, dermatologic, and musculoskeletal complications in the advanced stages of chronic kidney disease.
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When we pass from the agency which geologists term igneous, to aqueous and atmospheric agencies, we see the like ever growing complications of effects.
Essays on Education and Kindred Subjects Everyman's Library
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The age difference was a complication to the rela-tionship.
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She also developed thalamic pain syndrome, a special complication in stroke when the patient has suffered really severe brain trauma.
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Specialty referral is warranted for suspected complications and inpatient detoxification programs should be considered.
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With these provisos, and barring for the moment the complications arising from the consideration of intensional factors (such as time and modalities), we may proceed to review some core mereological notions and principles.
Wild Dreams Of Reality, 3
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Currently percutaneous tracheostomy is accepted as a safe and reliable bedside procedure; however, the potential for intraoperative complications such as tracheal damage still exists.
Health News from Medical News Today
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Finally, all these complications interact with a complex environment.
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The mystical homosexual power known as gaydar fails, and some delicious complications ensue.
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In addition, the pigs can also serve as models for observing the complications associated with diabetes, such as arteriosclerosis, and they could help researchers develop new medicines.
Fourth-Generation Pig Clones Born | Impact Lab
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Several other long-term complications arise with weight-loss surgery.
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Each blood sample was used once only to avoid complications resulting from localized microvaporization nucleated by residual coagulum particles.
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Which brings me to the final complication in that overplotted year.
Middlesex
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Combining his role as a director and actor in unscripted, unrehearsed scenes can lead to some obvious complications.
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A further complication is the possibility of secular drift, i.e. prevalence changing with the passage of historical time.
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In addition to genital lesions, patients with compromised immune systems may experience more severe, systemic complications, including in some cases cystitis, urethritis, cervicitis and meningitis.
DWS Pill Scribe
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The attendant dangers are urinary problems, infections, infertility and complications in childbirth.
Times, Sunday Times
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What are the possible common complications of intravenous pyelography?
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People at high risk for flu complications may be able to work with an allergist to be desensitized so they tolerate the vaccine.
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The more frequently we meet such difficult complications, and see with our own eyes their successful treatment, the more we learn to appreciate the fact, _that Apis cures to a certainty the most dangerous affections of this kind, and that the anti-psoric remedy corrects at the same time the primary degeneration of the tissues, without either interfering with the operations of the other drug, on the contrary, by assisting each other_.
Apis Mellifica or, The Poison of the Honey-Bee, Considered as a Therapeutic Agent
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The complications were that old spear wound, which inflamed, and they found that a splinter from the jagged tip had been left in.
Lady Bridget in the Never-Never Land
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In addition to risks related to surgery, complications can include pain at the implant sites, new pain, infection, lead (thin wire) movement/migration, device problems, interactions with certain other devices or diagnostic equipment, undesirable changes in urinary or bowel function, and uncomfortable stimulation (sometimes described as a jolting or shocking feeling).
Undefined
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Lee Petty, the venerable patriarch, died on April 5 at age 86 of complications from a stomach aneurysm.
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Pulmonary thromboembolism is a common complication in nephrotic patients.
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Patients also had complications including hematoma, or internal bleeding, following breast-enlargement surgery, infection, the development of dead tissue known as necrosis, cardiac arrests, breathing problems, pulmonary embolism and other blood clots, and allergic reactions.
Seeking a Safer Surgery
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Pneumonia is one of the common complications faced by bed-ridden patients.
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Waiting for results will still allow enough time to treat the strep infection and avoid potentially serious, preventable complications.
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The bad weather added a further complication to our journey.
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An additional complication is the fact that some Senate seats currently held by Democratic appointees may be immediately re-filled with Republicans, who have been steadfast in opposition to reauthorizing the benefits without massive spending cuts elsewhere in the budget.
RUINING CHRISTMAS: 1.2 Million Will Lose Benefits By Year's End Unless Congress Acts
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Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease.
Potential impacts of direct mechanisms of climate change on human health in the Arctic
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Soft tissue infection is an acceptable, if not expected, complication of piercing, but high ear piercing often results in auricular perichondritis.
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Head width, written track signal consistency, and other factors are variables, each of which adds complication.
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The complications arising from quadrivalent or trivalent plus univalent formation are not considered in this article.
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Bloodletting is an effective treatment for haemochromatosis, the effects can be monitored by testing transferrin saturation and serum ferritin, and the treatment can help to prevent serious complications of the disorder if diagnosed in a timely fashion.
Stuff And Nonsense
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Methods Black-diaphragm intraocular lens implantation were done in 14 patients (14 eyes) with traumatic aniridia after vitrectomy vision and complications were observed.
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Yet mitral valve prolapse has been associated with complications such as cerebral embolic events, infective endocarditis, severe mitral regurgitation requiring mitral valve surgery and even sudden death.
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Those who are advocates of the theory that this type of osteitis with its complications has its origin in the articular portion of the joint, claim that the upright pastern constitutes an important tendency toward ringbone.
Lameness of the Horse Veterinary Practitioners' Series, No. 1
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Once the new marrow had engrafted, the recipient ran the risk of that foreign marrow turning and attacking his or her own body as well as any residual leukemia left in the marrow, a deadly complication termed graft-versus-host disease or GVHD.
The Emperor of All Maladies
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While it has even been observed that the presence of G6PD deficiency could provide "an evolutionary advantage" in malarial endemic environments, it of course remains the case that one must first survive and surmount the ailment itself (and its attendant complications) in order to realize any of its ancillary immunological benefits.
Randall Amster: The Most Common Disease You've Never Heard Of
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Online advertising is riddled with complications and uncertainties which may take years to routinize.
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All pregnant women should avoid cigarettes and cocaine, which contribute to abruption and certain other pregnancy complications.
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By laser treatment and radiotherapy we aimed to achieve the benefits of both while minimising complications.
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Reye's syndrome is often misdiagnosed as encephalitis or meningitis, two complications that often appear in case studies of varicella deaths.
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Only in rare instances do serious complications supervene.
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The potential complication impairment of growth in Crohn's disease is unique to pediatric patients.
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I know of nowhere else where love of country comes so easily and devoid of complication.
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Most cases proved far more difficult, and never escaped the tangle of legal complications that surrounded the issue.
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However, there were complications that required additional surgery, jaundice possibly caused by gall-bladder disease, and pneumonia.
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Complications can occur if infection supervenes leading to an inflammation of the gall bladder.
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In software engineering, the degree of complication of a system or system component, determined by such factors as the number and intricacy of interfaces, the number and intricacy of conditional branches, the degree of nesting, the types of data structures, and other system characteristics.
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Nevertheless, uncertainties remain regarding several important aspects including impact on patient quality of life, impact of surgeon experience on outcome, late complications leading to reoperation, duration of comorbidity remission, and resource utilisation.
Dr. Sharma’s Obesity Notes » Blog Archive » UK Report Confirms Cost-Effectiveness of Bariatric Surgery
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Last year's Jaeger-LeCoultre Reverso grande complication à triptyque has three faces and lists 18 complications.
The Best Of Time
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This has led to appalling legal complications about who is allowed to represent whom.
Times, Sunday Times
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After users discovered that talcum powder caused patient complications similar to those caused by lycopodium powder, they began to transition to the use of cornstarch in 1947.
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Police and ambulance staff found injuries to his chest and back but his death was blamed on complications from gall bladder surgery.
Times, Sunday Times
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What are some of the specific complications associated with hydrocele / hernia surgery?
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Conclusion: Subperiosteal abscess of orbit can result in multiple complications such as loss of vision, osteomyelitis, cavernous sinus thrombosis, intracranial infection and abscess.
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Several complications arose in earlier patients that have not recurred after modification of the initial technique.
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Yet while complications ensue in satirical subplots in which love and money commingle, hilarity proves only sporadic.
Times, Sunday Times
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They understand complication and contradiction!
The Times Literary Supplement
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Consequently, haemodynamic and arrhythmic complications arose, with the need for repeat catheterisation and revascularisation, prolonged hospital stay, and increased costs.
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At the moment, one in three births involves complications requiring medical intervention.
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The egg fertilized in vitro implanted in the uterus of the birth mother with no further complications
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There was a complication and his leg became gangrenous and had to be amputated.
Times, Sunday Times
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TREATMENT: In the treatment of this disease, we have to attend to constitutional disturbances, inflamed joints, open urachus and complications such as constipation and diarrhoea.
The Veterinarian
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The result was that the babies with analgesia had much reduced postoperative endocrine changes, fewer complications and earlier recovery.
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The _popular_ free discussion of affairs of the last degree of complication, religious and state affairs, except during the _crisis_ period of revolution, only renders that worst of despotisms, anarchy, chronic; it seats in the social organism that political gangrene, demagogism, which has always hitherto sooner or later required the cauterization of military despotism in order to save even civilization.
The Christian Foundation, Or, Scientific and Religious Journal, March, 1880
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[Illustration: Fig. 58 -- Fibrosity of tarsus as a complication in chronic thoroughpin.]
Lameness of the Horse Veterinary Practitioners' Series, No. 1
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Yet while complications ensue in satirical subplots in which love and money commingle, hilarity proves only sporadic.
Times, Sunday Times
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The infection may spread to involve the parapharyngeal or retropharyngeal spaces with complications including mediastinitis and septic thrombophlebitis.
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INTERPRETATION: Pregnant women might be at increased risk for complications from pandemic H 1 N 1 virus infection.
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Diabetes is a chronic disease. Its complications play an important role in leading to the disability or death of patients. By now, the oral hypoglycemic agent is still a...
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That was for a single incident of adeno carcinoma (a lung lobectomy with complications requiring a second surgery to remove mrsa fluid congealed in my chest cavity).
Think Progress » Insurer Denies Life-Prolonging Treatment To Five-Year-Old Boy With Cancer
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Throughout life's complications, you should maintain such a sense of elegance.
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However, water-soluble rubidium, cesium, thallium, and silver minerals are virtually nonexistent and should pose no complication.
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Typically, lochia is not the result of any health complication and will end on its own when your body is ready.
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The risks of these complications depend, to some degree, on whether the condition is primary or secondary.
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If you have an ongoing chronic illness you might be at higher risk of complications.