How To Use Apoptosis In A Sentence
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Conclusion MTBE′s carcinogenicity to animals may relate to induction of cell proliferation and inhibition of cell apoptosis.
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AIM:To observe the effect of resveratrol, reactivator of silent information regulator 2 (SIR2), on myocardial cell apoptosis induced by ischemia and reperfusion in rats and SIR2 expression.
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Result: Methylprednisolone inhibited the activity of neural stem cells in vitro, and also promoted apoptosis of neural stem cells.
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BHT could induce apoptosis to pulmonary macrophage in the perfusate of isolate perfused rat lung as examined by the technology of PI fluorescence stain and comet assay.
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Thirdly, simvastatin inhibits endothelial cell apoptosis and preserves ischaemic vasculature, perhaps maintaining a competent vascular supply to the macula.
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Raffoul JJ et al. Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest.
Craig Cooper: Soy: When It's Good, When It's Bad, And How To Tell
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When they exposed cancer cells to these phytonutrients, the cells self-destructed technically, such self-destruction is called apoptosis.
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So, when a telomere gets short, that's when either senescence or apoptosis is triggered.
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In addition, the signals that lead a cell to necrosis or apoptosis remain to be elucidated.
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Hyperglycosylated hCG inhibits apoptosis in extravillous invasive cytotrophoblast cells promoting cell invasion, growth and malignancy.
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We wished to evaluate the efficacy of Pul8 photosensitizer in the induction of apoptosis because its anhydride group may provide the possibility of coupling this photosensitizer to cell-targeting agents like antibodies.
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Inhibit thrombocyte function, inhibits apoptosis in tumour (insulinoma) cells and protein degradation (7) 6.
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Scattered apoptosis and proliferation in the injured epithelium, lamina propria and serosa accompany the peak inflammatory cell infiltration on day 7.
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Apoptosis can be induced by immune cells and cytotoxins, and by changes in homeostatic signals.
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In addition to allowing regeneration of syncytiotrophoblast and investigating chronic regulation of apoptosis and autophagy, another reason for us to incubate villous explants and cytotrophoblastic cells under normoxia or HR for 48 hours before administration of vitamins C and E is to precondition the trophoblast cells with our experimental settings.
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Kiyokawa N, Katagiri YU, Taguchi T, Suzuki T, et al. (2000) Globotriaosyl ceramide (CD77/Gb3) in the glycolipid-enriched membrane domain participates in B-cell receptor-mediated apoptosis by regulating lyn kinase activity in human
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It also can inhibit growth of xenograft tumor in athymic mice, accelerate necrosis and apoptosis of tumor cells.
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ADSC transplantation may reduce apoptosis and secret VEGF to promote the angiogenesis, and improve neural functional in intracerebral hemorrhage rats.
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In apoptosis, DNA is degraded into oligonucleotides with a few hundreds of basepairs that subsequently diffuse out of the nucleus.
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Recently the intracellular protein BAT3, which is involved in DNA damage induced apoptosis, was identified as a ligand for NKp30.
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It also can inhibit growth of xenograft tumor in athymic mice, accelerate necrosis and apoptosis of tumor cells.
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Calcium ions as mediators of intracellular signalling are crucial for development of apoptosis.
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We have found that certain alleles do show interactions with only one of these inducers of apoptosis.
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The process of cells dying is a highly controlled one that is called apoptosis, which is a Greek word that means “petals dropping off a plant.”
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The fusion proteins result in abnormal functions of cell self-renewal, proliferation, differentiation, and/or apoptosis.
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Both have been shown to inhibit DNA synthesis and arrest fibroblast growth without apoptosis and thus preserve the cytoarchitecture.
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It also reported that inhibition of CDK2 by seliciclib suppressed lung cancer growth both in vitro and in vivo of lung cancer cells addicted to CDK2/cyclin E; and lung cancer cells underwent apoptosis or cell suicide by induction of a novel mechanism called anaphase catastrophe, as illustrated in the journal's front cover.
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Apoptosis modulators such as caspase inhibitors might one day come close to curing acute brain injury.
The Scientist
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Forum: Science Jobs Forum Posted By: Jessica Post Time: 10-29-2008 at 10: 18 PM what role do lysosomes play in apoptosis, digit formation, and syndactyly?
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That process is called senescence—when the cells stop dividing permanently, or they undergo apoptosis the cell death we described earlier in the book, in which they’re broken up and reabsorbed.
You Staying Young
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We expected the tumor cells to undergo programmed cell death, or apoptosis.
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The systemic immune effects include increased apoptosis of thymocytes, decreased macrophage phagocytosis, thymic atrophy and diminished allograft rejection.
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Xu YA, Gada H, Guttmann RP, Siman R (2003) Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis.
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Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, et al. (2009) Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis.
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One of the menaquinone forms of vitamin K (MK-4, also called menatetrenone) has repeatedly been show to block formation of too many osteoclasts and perhaps also to initiate their programmed cell death (a process called apoptosis).
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Objective: To investigate the effect of hair cell apoptosis on hearing loss of perilymphatic fistula ( PLF ) in guinea pig.
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The short prodomains caspases induced cell apoptosis, which played an effector as a target protein of cytosol or nucleus.
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Eosinophils in vitro exhibited different stages of apoptosis, ending with secondary necrosis distinct from in vivo eosinophil cytolysis.
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The specific process of apoptosis first appeared with the evolution of metazoan animals and has been well conserved in all animal phyla.
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Radioiodine can cause significant apoptosis and mitotic cell death in the thyroid tissue.
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To hint 11-sour testosterone main to interfere with normal differentiation development of first spermatocyte, apoptosis second spermatocyte and nematoblast.
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Many abstracts focused on hot topics such as angiogenesis and apoptosis.
The Scientist
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Dysfunction in apoptosis can lead to cancer or neurodegenerative diseases.
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In addition to morphomechanical changes, hDMPK A expression induces physiological changes like loss of mitochondrial membrane potential, increased autophagy activity, and leakage of cytochrome c from the mitochondrial intermembrane space accompanied by apoptosis.
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One of the most promising therapeutic uses of cannabinoids is linked to their ability to induce apoptosis in tumors, including in astrocytoma subclones grown either in vitro, subcutaneously in immunodeficient mice, or intracranially in rats
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This report suggested the likelihood that mitochondria might actually control apoptosis.
The Scientist
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Colonized monolayers demonstrated a time-dependent series of changes: staining with labelled phalloidin identified accumulation of actin at the cell junctions; ZO-1 staining revealed a loss of Caco-2 tight junction integrity; and Hoechst staining showed condensation and fragmentation of nuclear material consistent with apoptosis.
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It has recently been reported that the release of mitochondrial hexokinase and some associated proteins may play a role in the onset of the apoptosis cascade27.
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Certainly both groups find that p53 levels rise following radiation, and this could specifically activate transcription of apoptosis-inducing genes.
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Janes and colleagues altered the cells to express or make the cancer-killing protein called TNF-related apoptosis-inducing ligand or TRAIL.
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Apoptosis is the process of cell suicide that enables controlled removal of cells without inducing an inflammatory response.
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ConclusionEstrogen can repress osteoblasts apoptosis of rats induced by serum hungry.
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The intracellular expression of TLR3 and type I IFN inducible myxovirus resistance protein A (MxA) protein as well as the level of apoptosis were analyzed by flow cytometry.
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So did the levels of LEP and INS . However, the effect on promoting fat cell apoptosis was not obvious.
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In addition to the alveolar epithelial cells, host immune cells located outside the lung, such as splenic and thymic cells, undergo apoptosis during influenza infections.
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They reproduced wildly and refused to obey the signals that demand self-identification and, failing that, apoptosis - cellular suicide.
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Taken together, these results show that thiram induces GSH depletion, leading to oxidative stress and finally cell death by apoptosis.
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Whether apoptosis turns out to be a feature of garden-variety human emphysema awaits much further study, but these initial observations are provocative.
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She thought of how the word apoptosis meaning “cell death,” came from the Greek word for “falling leaves.”
The Life You Longed For
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Method Apoptosis was assessed by DNA gel electrophoresis, oil - immersion microscopy.
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Objective To explore the effects of zearalenone (ZEA) on proliferation and apoptosis in estrogen-dependent human breast cancer MCF-7 cells and the likely underlying molecular mechanisms.
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This kit contains the necessary reagents to measure apoptosis by flow cytometry based on the presence of active caspase-3.
The Scientist
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Numerous studies have shown that many kinds of cancer cells overproduce this caspase inhibitor, apparently to stymie the cellular-suicide program called apoptosis.
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The role of macrophage apoptosis in containing the growth of the bacilli is also discussed.
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Confirmation of apoptosis was made by hypodiploid PI staining and loss of mithochondrial membrane potential.
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In cell culture studies, curcumin supressed preadipocyte differentiation, promoted adipocyte apoptosis (programmed cell death) and inhibited growth of adipokine-stimulated angiogenesis.
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Aging is characterized by mitochondrial dysfunction, with a disruption in energy production that eventually leads to cell death by apoptosis.
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Apoptosis was detected by acridine orange (AO) staining, DNA ladder assay and flow cytometric analysis.
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However, in cryptorchid testis, in which most germ cells undergo apoptosis, only a few of SRG4 is observed, suggesting that SRG4 may be as a specific marker to evaluate the process of spermatogenesis.
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Conclusion Direct-current stimulation may have intervention effects on spinal cord neuron apoptosis after sciatic nerve transection .
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Since CLIPR-59, CLIP-170-related protein, has recently been identified as a microtubule binding protein associated with lipid rafts, we analyzed the role of GD3-CLIPR-59 association in lymphoblastoid T cell apoptosis triggered by CD95/Fas.
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Once activated, caspase-3 is a marker for cells undergoing apoptosis.
The Scientist
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Objective : To explore the molecular mechanism of aluminum induced the apoptosis of neurocytes in rats'hippocampus.
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Due to its specific molecular mechanism, these compounds could induce apoptosis in retinoic acid-resistant or multi-drug-resistant tumor cells.
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Preclinical studies suggest that As 2 O 3 induces apoptosis and possibly differentiation in APL cells.
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One of the menaquinone forms of vitamin K (MK-4, also called menatetrenone) has repeatedly been show to block formation of too many osteoclasts and perhaps also to initiate their programmed cell death (a process called apoptosis).
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Adult athymic rats did not develop emphysema as compared with adjuvant-only injected rats and did not show septal cell apoptosis following xenogeneic EC injection (data not shown).
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Current research suggests that, during the final stages of wound healing, myofibroblasts, again, generally identified by [alpha] smooth muscle actin expression, die through apoptosis to leave an acellular scar.
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Objective:To investigate the influence of Ditan decoction on apoptosis of cerebral ischemic-reperfusion injury in rats.
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This kit contains the necessary reagents to measure apoptosis by flow cytometry based on the presence of active caspase-3.
The Scientist
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Homocysteine also causes DNA strand breakage, resulting in mitochondrial membrane damage, nuclear disintegration, and apoptosis of neuronal cells.
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Methods The survival rate and apoptosis rate of QBC939 after being treated with different density of 5-aza-2'-deoxycytidine were detected by using the method of MTT and flow cytometry.
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In animal cells, Prx are implicated in complex cellular processes including cell proliferation, differentiation, and apoptosis.
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An apoptotic gene (TNF-alpha induced protein 3) was highly over-expressed (p = 0.001) in the cryptorchid samples suggesting a role for apoptosis as a cause for poor sperm densities.
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Vesalainen S, Lipponen P, Talja M, Syrjanen K. Histological grade, perineural infiltration, tumour-infiltrating lymphocytes and apoptosis as determinants of long-term prognosis in prostatic adenocarcinoma.
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Furthermore, they may cause premature depletion of the follicle pool by induction of follicular atresia or oocyte apoptosis and, thereby, lead to reduced fertility.
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When AS1411 binds to nucleolin on cancer cells, it is internalised and causes apoptosis through interference with various functions of nucleolin.
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In neurons this is called apoptosis; in humans it is called depression, grief, and suicide.
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We have reported that turmeric also activates the lymphocytes and induces apoptosis to tumor cells.
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Then we observe the change of myocardium enzymatic dynamics and detect myocyte apoptosis with electronic microscope and situ end labeling way.
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Chloridion participated in various kinds of biological function, such as cellular immunologic response , cell migration, cellular proliferation and differentiation, apoptosis.
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The analysis of correlations between the expression pattern of the tested miRNAs and CP induced limb phenotypes implies that miRNAs regulating apoptosis may differ from each other with respect to their functional role in teratogenesis: some miRNAs act to protect embryos, whereas other miRNAs boost a teratogen-induced process of maldevelopment to induce embryonic death.
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Apoptosis is a ubiquitous process by which multicellular organisms are able to maintain a balance between cell proliferation and death.
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Objective To explore the effects of heparan sulphate in combination with constant magnetic fields on the proliferation and apoptosis of the human hepatoma cell line (HepG2).
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Conclusion: PKC was closely related with apoptosis of the olfactory cells, it should be considered that negative feedback effect of PKC on the growth of olfactory bulb in rats.
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The anti-apoptotic members block apoptosis, whereas others, called the pro-apoptotic members, accelerate the process.
The Scientist
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Exercise - induced fatigue can lead to apoptosis and dysfunction of autonomic nervous system.
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Objective: To investigate the status of activation and apoptosis of peripheral blood mononuclear cells (PBMC) in patients with polymyositis (PM) and dermatomyositis (DM).
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Apoptosis is a normal and essential part of early development, when brain cells proliferate rapidly and some are killed off, but little is known about how apoptosis of growing neurons is regulated.
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See: "The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate.
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Soucie EL, Dlugosz PJ, Cruz-Aguado JA, Penn LZ, et al. (2005) Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis.
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The NYU researchers screened a library of 2,000 well-known drugs and identified members of the benzimidazole family for their ability to inhibit melanoma growth and induce programmed cell death (apoptosis) of malignant melanoma cells without affecting normal melanocytes (pigment-producing cells).
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ANTITUMOR Immune enhancement; activating macrophages, T cells, and NK cells; increasing TNF-α production; inducing cancer cell apoptosis and cytotoxicity
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Programmed cell death by apoptosis plays a key role in molding the form of chick and mammalian limbs, especially the digits.
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Thus cells without mtDNA can undergo apoptosis when either deprived of survival factors or exposed to high concentrations of staurosporine.
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In a series of studies, they have shown that photosensitizers that localize in mitochondria are very efficient inducers of apoptosis.
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Fluorouracil induces apoptosis by inhibition of the enzyme thymidylate synthase during DNA replication.
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Finally, 7 of 15 interactors with a hitherto unknown function were shown to interfere with apoptosis.
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Does this increase in receptor expression modify the efficacy of cannabinoids at inducing apoptosis in astrocytomas?
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Apoptosis in colonic crypt epithelial cells was measured by observing the frequency of karyorrhexis and karyolysis in 1000 cells.
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Conclusion Rhodiola extracts possess the effects of against lipid peroxidation and apoptosis.
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Cell morphology and DNA gel electrophoresis were used to observe the apoptosis.
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Summary of Background Data. The stress-activated mitogen-activated protein kinase pathways including ASK1 transmitted apoptosis signals after acute spinal cord injury.
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It has been demonstrated that isolated cytotrophoblasts from preeclampsia or fetal growth restriction and their derived syncytiotrophoblast are more sensitive to apoptosis compared with those from normal pregnancies
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The pathway will clearly be modulated by other genes that regulate apoptosis.
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They reproduced wildly and refused to obey the signals that demand self-identification and, failing that, apoptosis - cellular suicide.
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Separately, they showed no effect on premalignant polyps called adenoma cells, causing programmed cell suicide know as apoptosis.
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Conclusions Fetal spinal transplants can inhibit the apoptosis and improve rats hind limb function after SCI.
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Certainly both groups find that p53 levels rise following radiation, and this could specifically activate transcription of apoptosis-inducing genes.
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Apoptosis research continues and includes developmental biology, cancer research, genetics, immunology, and toxicology.
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The morphological and biochemical changes typical of apoptosis are orchestrated by caspases, a family of cysteine proteinases, which cleave proteins after aspartate residue.
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The result is premature apoptosis (programmed cell death) of progenitors and failure of stem cells to mature and differentiate.
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PP2A, PP4 or PP5 may have to be considered as additional targets in the synergistic cooperation with proteasome inhibitors, since they all are inhibited by cantharidin, and have been implicated in contributing to apoptosis regulation
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Recently, we have also shown in 9L rat gliosarcoma tumor grown intracranially that PDT with low doses of ALA or light can induce tumor cell-specific apoptosis with no significant damage to normal brain cells.
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Many studies atresia caused by granulosa cell apoptosis is associated with the subsequent oocyte developmental competence.
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The effect of thymic peptide on the functions of tissue macrophages, tumor-associated macrophages, and tumor-induced apoptosis of thymocytes was studied.
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Increased cell proliferation and, decreased apoptosis in congenital cystic adenomatoid malformation: Insights into pathogenesis.
Congenital cystic adenomatoid malformation publications
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AIM:To observe the effect of resveratrol, reactivator of silent information regulator 2 (SIR2), on myocardial cell apoptosis induced by ischemia and reperfusion in rats and SIR2 expression.