1. an antineoplastic drug that inhibits the utilization of a metabolite
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How To Use antimetabolite In A Sentence

  • Methotrexate is currentlythe only antimetabolite approved by the FDA as a treatment for psoriasis. Psoriasis Guru » Blog Archive » How Does Methotrexate Work?
  • Methotrexate is an antimetabolite that, apart from its use in malignant disorders, is taken orally in low doses for the control of conditions such as rheumatoid arthritis and psoriasis.
  • In 1940, Woods and Fildes (1,2) had put forth the antimetabolite theory to explain the action of sulfonamides on bacteria, suggesting that the sulfonamides interfered with the utilization of a necessary nutrient, para-aminobenzoic acid. Nobel Lecture The Purine Path To Chemotherapy
  • Drugs such as alkylating agents, antimetabolites, anticonvulsants, chlorothiazide diuretics and estrogens can inhibit platelet production by suppressing megakaryocyte production. (2,3)
  • Clofarabine, a type of drug called a purine nucleoside antimetabolite, works by blocking the production and repair of DNA, the building blocks of genes.
  • Therefore, acyclovir is transformed into its corresponding nucleotide which is the active antimetabolite and the growth of the virus is inhibited (Figure 3). Physiology or Medicine 1988 - Press Release
  • This protocol differed from previous protocols, in that more intensive systemic antimetabolite therapy was given before and during radiotherapy.
  • When this process is allowed to proceed normally it is also called “metobolizing,” somethotrexate is also called an “antimetabolite.” Psoriasis Guru » Blog Archive » How Does Methotrexate Work?
  • The major categories are alkylating agents, antimetabolites, plant alkaloids, anti-tumor antibiotics, and steroid hormones.
  • We have modified the recently completed St Jude protocol to withhold systemic antimetabolites during radiotherapy.
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