1. an acid formed as an intermediate product of the metabolism of tyrosine and phenylalanine
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How To Use alkapton In A Sentence

  • Large blisters, like these, are called bullae alkaptonuria, ochronosis X-ray lower lumbo-sacral spine and sacro-iliac joints showing normal sacro-iliac joints and calcification of intervertebral discs alkaptonuria, ochronosis grossly calcified intervertebal discs alkaptonuria, ochronosis early ankylosis of spine alkaptonuria, ochronosis bluish spots on his sclera alkaptonuria, ochronosis Bluish discoloration os ear cartillage hypertrophic osteoarthropathy Note diffuse periosteal new bone formation of the distal radius and ulna. Recently Uploaded Slideshows
  • Pigmentation of the sclera and ear cartilage occurred only after the age of 30 years and is extremely variable in severity. 3 Tendon and ligament ruptures occur with minimal provocation, and kidney stones probably form because of the extremely high levels of urinary HGA excretion (renal clearance rates of 400 to 500 ml per minute). 4�Diagnosis depends on typical radiological findings and demonstration of reducing substance-homogentisic acid in the urine. 4 Several therapeutic approaches have been used in patients with alkaptonuria. 5 High-dose vitamin C decreases urinary benzoquinone acetic acid but has no effect on HGA excretion and no credible studies have shown that treatment with vitamin C is clinically effective. 6 The main therapeutic step is direct pharmacologic reduction of HGA production with nitisinone, a triketone herbicide that inhibits Recently Uploaded Slideshows
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