How To Use Active site In A Sentence
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The second step involves binding of phospholipid molecules in the active site of the adsorbed enzyme.
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The implementation of the aldol reaction in the active site of an enzyme has been an important challenge.
Biosingularity
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This reaction causes the shift of a neighboring amino acid, which eventually leads to the rigidification of two otherwise flexible loops, one of which provides two histidine residues necessary to complete the enzymatically competent active site architecture.
Journal of Biological Chemistry current issue
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It may not be entirely coincidental that many modern biological catalysts have zinc ions in their active sites.
Infinite in All Directions
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The active site of peptidoglycan lysis is disrupted in lactalbumin.
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Klaus wanted me to analyze the active site of the enzyme aspartate transcarbamylase by chemically modifying different amino acids within it, and gave me a bench in a student lab.
Martin Chalfie - Autobiography
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They are running at an average of just under one house per fortnight on active sites.
The Sun
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The active site or prosthetic group of all the cytochromes is an iron containing porphyrin, or heme.
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The long hydrophobic tail of vinyl butyrate was placed along the hydrophobic cleft of the active site, while the bulky phenyl ring was fitted on the opposite side.
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They are running at an average of just under one house per fortnight on active sites.
The Sun
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The active site of trypsin involves a catalytic triad consisting of the amino acids serine, histidine and aspartic acid.
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We also show that an active site cysteine is important for catalysis, likely in the protonation of uracil during tRNA reduction.
Journal of Biological Chemistry current issue
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M.; Little, D.B.; Schalk, M.; Croteau, R.: Hydroxylation of limonene enantiomers and analogs by recombinant (-) - limonene 3 - and 6-hydroxy - lases from Mint (Mentha) species: Evidence for catalysis within sterically constrained active sites.
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Location of the active site and relative differences in tissue distribution can also be important.
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The PET scan then detects the radiation being emitted from the active sites.
Advanced Educational Psychology For Educators, Researchers and Policymakers,
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The edge of the ship channel is one of the most attractive sites for housing on the whole waterfront.
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He said it was an attractive site because it offered easy access to the motorway network, and there was also the potential to gain European funding.
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Enzyme inhibitors traditionally target the active site by matching its steric, hydrogen binding, and charge constraints.
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Second, the enzymatic activity for the active site mutants was determined in vitro.
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The potential energy surface in the active site was generated using the approximate valence bond method.
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The confluence of the rivers Ouse and Fosse was a naturally attractive site to the military mind.
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Just look at Asn-Asp and Gln-Glu tRNAs and their codon sequence with an understanding of charging proteins and the likely-hood of evolving similar shaped active sites and similar anti-codons.
The standard genetic code enhances adaptive evolution of proteins - The Panda's Thumb
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Our findings indicate that the putative active site nucleophile is not required for FDTS catalysis, and no alternative nucleophilic residues capable of serving this function can be identified.
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Amino acid mutations associated with andromonoecy are located at the active site of CsACS2.
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By mutations that place the histidine in a similar distance to the heme as in the active site of peroxidases, compound I of myoglobin has been observed, probably owing to an increased rate of heterolysis.
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Kuntz DA, Hoffman D, Janzer RC, Gerber-Lemaire S, et al. (2008) Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: Optimizing the fit to the active site.
PLoS ONE Alerts: New Articles
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CsACS2 like CmACS-7 is specifically expressed in buds determined to develop a carpel in carpel primordia and, like in melon, loss-of-function mutations, located near the active site of CsACS2 are associated with andromonoecy.
PLoS ONE Alerts: New Articles
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In particular, the team identified that the first step of the FTDS-catalyzed reaction involves the transfer of a proton and two electrons, known as a hydride, from a flavin co-factor molecule to dUMP whereas the first step of the TS-catalyzed reaction involves an amino acid from the enzyme's active site forming a bond with dUMP.
EurekAlert! - Breaking News
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ATP binding sites are regulatory sites in the nitrogenase and the acetylene reduction active sites are catalytic sites in the nitrogenase.
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They are running at an average of just under one house per fortnight on active sites.
The Sun
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This high reactivity is of direct importance for the catalytic activity of the enzyme, but Moore and Stein also found it possible to utilize it to label two amino acids in the active site by chemical modification.
Nobel Prize in Chemistry 1972 - Presentation Speech
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The active site or prosthetic group of all the cytochromes is an iron containing porphyrin, or heme.
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The PET scan then detects the radiation being emitted from the active sites.
Advanced Educational Psychology For Educators, Researchers and Policymakers,
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This group, including trypsin and chymotrypsin, evolved from a common ancestral protease, and all use the same mechanism of action at their active site.
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The second scission occurs when a protease uses an unusual active site within the hydrophobic lipid environment to recognize and cleave the truncated target protein, releasing both the lumenal fragment and the cytoplasmic domain from the membrane.
PLoS Biology: New Articles
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The catalytic region of the enzyme, called the active site, is a very small pocket on its outer surface.
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Just look at Asn-Asp and Gln-Glu tRNAs and their codon sequence with an understanding of charging proteins and the likely-hood of evolving similar shaped active sites and similar anti-codons.
The standard genetic code enhances adaptive evolution of proteins - The Panda's Thumb
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The Market Square was also an attractive site and the newly renovated hotel and Black's Coffee shop just opposite were real eye-catchers.
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Given that allostery represents one of the most common and powerful means to regulate protein function, the traditional drug discovery approach of targeting active sites can be extended by targeting allosteric or regulatory protein pockets that may allow the discovery of not only novel drug-like inhibitors, but activators as well.
BioMed Central - Latest articles
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The pseuoduridine synthases (Y synthases) are responsible for this reaction, and they fall into five families that share very limited sequence similarity but have the same overall fold and active site architecture, including an essential Asp that likely serves as both a nucleophile and a general base during the reaction.
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