Prepositions after verbs

Infect with or by?

The verb "infect" is commonly used with with to name a disease or harmful influence. By can introduce the source or agent. Other prepositions in the query usually function separately rather than as fixed complements.

Quick answer

Common patterns with infect

Use infect someone with + disease or virus. Use infect by mainly in passive structures such as be infected by mosquitoes. In, as, and during are usually separate adjuncts, not fixed patterns after infect.

The child was infected with the virus.
Several patients were infected by contaminated equipment.
The system was infected with malware after the download.

Choose the pattern by meaning

These forms are not interchangeable. Choose the construction by meaning, not by which preposition appears most often.

1
infect with + disease/virus

Naming what spreads

With introduces the illness, virus, or harmful influence.

He was infected with tuberculosis.
The computers were infected with spyware.
2
infect by + source

Naming the agent

By is common in passive structures to identify the source or carrier.

The crops were infected by insects.
She was infected by a contaminated needle.
3
infect in + place/group

Using in as an adjunct

In usually refers to location or group, not a fixed complement.

The disease spread after it infected residents in the camp.
4
infect during + period

Using during for time

During introduces a time expression rather than completing the verb.

Many workers were infected during the outbreak.

See the difference in context

The same subject can take different constructions because each sentence answers a different question.

Construction
Example
Meaning
infect with
The patient was infected with influenza.
Names the disease or harmful thing.
infect by
The animals were infected by parasites.
Names the source or agent.
infect in
The virus infected students in several schools.
In refers to location or group.
infect as
The phrase "infect as" is not a standard pattern.
As is generally not used directly after infect.
infect during
He was infected during the winter season.
During adds a time expression.

Common mistakes

Some combinations appear in real text but do not mean what learners often assume.

Using by for the disease

Use with to name the illness itself.

✕ She was infected by malaria. ✓ She was infected with malaria.

Using as after infect

As is not a normal complement after infect.

✕ They infected him as a virus. ✓ They infected him with a virus.

Confusing with and by

With names what spreads; by names the source.

✓ The patient was infected with dengue by mosquito bites.

Treating during as a fixed complement

During introduces time, not the object of infect.

✓ Many people were infected during the storm.

Quick practice

Choose the expression that matches the intended meaning.

1. The computer was infected ___ malware.
2. The patients were infected ___ contaminated water.
3. Many workers were infected ___ the outbreak.

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Frequently asked questions

Do we say infected with or infected by?

Both are correct. With names the disease or virus, while by names the source or carrier.

Can infect be used for computers?

Yes. Infect with malware or viruses is common in technology contexts.

Is infect as correct?

No. As is not normally used directly after infect.

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