How To Use Alkylating agent In A Sentence
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Chemical mutagens are classified as alkylating agents, cross-linking agents, and polycyclic aromatic hydrocarbons (PAHs).
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The mms4 mutant has previously been found to be sensitive to alkylating agents such as MMS, weakly sensitive to ultraviolet light, and resistant to X rays.
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Parp is activated by DNA strand breaks induced by alkylating agents.
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The hydrocarbon diperchlorate products have utility as detonatable sensitizers for explosives and alkylating agents.
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PARP is a nuclear enzyme activated by DNA strand breaks induced by alkylating agents or X-rays.
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Drugs such as alkylating agents, antimetabolites, anticonvulsants, chlorothiazide diuretics and estrogens can inhibit platelet production by suppressing megakaryocyte production. (2,3)
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All four mutant lines displayed an increased sensitivity to the bifunctional alkylating agent mitomycin C.
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People undergoing cancer treatment such as radiation and chemotherapy and use of radiomimetic alkylating agents develop secondary Myelodysplastic syndrome as an effect of late toxicity caused by the treatment.
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Consistent with these functions, mei - 41 mutants are sensitive to hydroxyurea, an inhibitor of DNA replication, and DNA-damaging agents such as X-ray and alkylating agents.
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We found that it is also hypersensitive to various DNA-damaging agents, including UV irradiation and the DNA alkylating agent MMS.
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The major categories are alkylating agents, antimetabolites, plant alkaloids, anti-tumor antibiotics, and steroid hormones.
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There has been some investigation into the natural alkylating agent 4-ipomeanol, but investigation was suspended after the first clinical trials.
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Nitrosureas - a group of drugs that act similarly to that of alkylating agents.
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Both parental and cells were equally sensitive to damage by the alkylating agent.
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Epoxy compounds are highly reactive bifunctional alkylating agents, which may attack and bind covalently to DNA and cause mutagenic events.
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While life-saving in many cases, radiotherapy and chemotherapy with alkylating agents, such as busulfan, cyclophosphamide and dacarbazine, can damage DNA.
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The few oxonium ions that have been isolated and purified are paired with inert counterions and considered among the most powerful alkylating agents in the laboratory.
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Ovarian or pelvic irradiation with or without treatment with alkylating agents may adversely affect female fertility and pregnancy outcome.
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Several different types of drugs have been developed - alkylating agents, for example, inhibit cell division, whilst anti-metabolites interfere with enzyme systems and block vital processes.
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Acute leukemia frequently has been described as a late complication of chemotherapy with alkylating agents in patients treated for multiple myeloma.
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Alkylating agents function by reacting with and disrupting the structure of DNA.
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All carbocations are strong alkylating agents with a high affinity for groups which donate or share their electrons, such as halide ions, hydroxyl anions and amines.
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Cells expressing pol are hypersensitive to DNA alkylating agents and express neoplastic phenotype in animal model.
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Methyl methanesulfonate and cyclophosphamide are alkylating agents that differ in their mode of action.
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PARP is a nuclear enzyme activated by DNA strand breaks induced by alkylating agents or X-rays.
